Vecsei Z, Csathó A, Thuróczy G, Hernádi I · 2013
Researchers tested the effects of UMTS RF EMF exposure on the thermal pain threshold of 20 young adult volunteers, measuring responses on the surface of the fingers. The exposure lasted 30 minutes and was applied to the head through a patch antenna, with SAR kept constant at 1.75 W/kg. Thermal pain thresholds were intact, but a reduced desensitization effect between repeated stimulations was observed on the contralateral side during genuine UMTS exposure. Subjective pain ratings were marginally decreased in the genuine exposure condition only.
Parazzini M et al. · 2010
Researchers investigated the potential effects of UMTS exposure at a high specific absorption rate on the human auditory system in 73 healthy young adults. Participants received a 20-minute UMTS exposure at 1947 MHz with a maximum SAR of 1.75 W/kg in a double-blind comparison of genuine and sham exposure. No consistent pattern of effects was found on hearing thresholds, otoacoustic emissions, or auditory evoked potentials. The study concluded that short-term UMTS exposure at this SAR does not cause measurable immediate effects on the human auditory system.
Güler G et al. · 2012
Researchers exposed infant rabbits to 1800 MHz GSM-like RF radiation and measured lipid peroxidation and DNA damage in their livers. Lipid peroxidation levels in liver tissue increased in both female and male infant rabbits under RF radiation exposure. Liver 8-OHdG levels, a marker of DNA damage, increased in exposed female rabbits but showed no change in exposed male rabbits. The researchers concluded that GSM-like RF radiation may induce biochemical changes by increasing free radical attacks to structural biomolecules in the rabbit model.
Dawe AS et al. · 2008
Researchers exposed a transgenic strain of the nematode C. elegans to radiofrequency fields at 1.8 GHz and a specific absorption rate of approximately 1.8 W/kg. For both continuous wave and Talk-pulsed exposures lasting 2.5 hours, there was no indication that RF exposure could induce reporter expression above sham control levels. When background reporter expression was moderately elevated in sham controls, the researchers found some evidence that reporter expression may be reduced by approximately 15% following exposure to either Talk-pulsed or CW RF fields.
Franke H et al. · 2005
Researchers investigated the influence of a generic UMTS signal on barrier tightness, transport processes, and morphology of porcine brain microvascular endothelial cell cultures serving as an in vitro blood-brain barrier model. The cells were exposed continuously for up to 84 hours at an average electric-field strength of 3.4-34 V/m with a maximum of 1.8 W/kg under athermal conditions. Barrier tightness measured by 14C-sucrose and serum albumin permeation and by transendothelial electrical resistance remained unchanged compared to sham-exposed cultures. Permeation of transporter substrates and the localization and integrity of the tight-junction proteins occludin and ZO1 were also unaffected.
Hata K et al. · 2005
The study aimed to clarify the effects of short-term 1439 MHz TDMA exposure on melatonin synthesis in rats. Researchers investigated 208 male and female rats with brain SAR of 7.5 W/kg and whole-body SAR of 1.9 to 2.0 W/kg. After a 12-hour light-dark cycle, serum and pineal melatonin and pineal serotonin were measured by radioimmunoassay in darkness. No significant differences in melatonin or serotonin levels were found between exposed, sham, and cage control groups.
Lagroye I et al. · 2004
Researchers exposed C3H 10T½ cells to 2450 MHz CW microwaves at 1.9 W/kg for 2 hours, then irradiated them with 4 Gy gamma rays, and used the single-cell gel electrophoresis assay to detect DNA damage. Ionizing radiation induced significant DNA damage, but microwave exposure alone caused no detectable DNA damage. Microwaves did not impede DNA migration induced by gamma rays, and no evidence of DNA–protein crosslinks or changes in DNA-associated protein was found after microwave exposure.
Wang K et al. · 2017
Researchers examined the effects of a single 30-minute exposure to 1.8 GHz radiofrequency electromagnetic radiation on recognition memory in mice, using the novel object recognition task. Exposure at an intensity above 2.2 W/kg SAR produced a significant, density-dependent increase in the recognition memory index, with no corresponding changes in spontaneous locomotor activity. The researchers also found that exposure increased dendritic-spine density and length in hippocampal and prefrontal cortical neurons, and significantly altered neuronal excitability in pyramidal neurons. The SAR used in the study was 3.3 W/kg, which the researchers noted was outside the range encountered in normal daily life.
Suzuki S et al. · 2017
The purpose of this study was to evaluate the effects of 3rd-generation (3G) cellular phone radiofrequency-electromagnetic wave (RF-EMW) exposure on fertilization and embryogenesis in mice. Oocytes and spermatozoa were exposed to 1.95 GHz RF-EMWs at 2 mW/g for 60 minutes or sham exposure. After RF-EMW exposure, in vitro fertilization and intracytoplasmic sperm injection were performed. Groups compared were both exposed, both non-exposed, one exposed, and the other non-exposed. Fertilization, embryogenesis, and blastocyst formation rates did not change significantly across the four groups.
Kim HS et al. · 2017
Researchers exposed Sprague-Dawley rats to a 915 MHz radiofrequency identification signal at a whole-body specific absorption rate of 2 W/kg for 8 hours per day, 5 days per week, for 2 weeks. The number of red blood cells and values of hemoglobin, hematocrit, and red blood cell indices were increased in the RFID-exposed group compared with the cage-control and sham-exposed groups. The number of white blood cells, including lymphocytes, was decreased in RFID-exposed rats, though T-cell counts and the CD4+/CD8+ ratio showed no statistically significant difference between sham-exposed and RFID-exposed groups. The researchers noted that these changes do not necessarily indicate that RFID exposure is harmful, as they were within the normal physiological response range.
Valbonesi P, Franzellitti S, Bersani F, Contin A, Fabbri E. · 2016
Researchers exposed rat PC12 cells to a 1.8 GHz 217-GSM signal at 2 W/kg SAR for 24 hours. AChE enzyme activity was measured by Ellman's method, mRNA by real-time PCR, and protein by Western blotting. AChE enzymatic activity increased 1.4-fold in exposed cells, while mRNA and protein expression were not affected. The authors report this as the first evidence of RF-EMF effects on AChE activity in mammalian cells at this SAR.
Erdem Koç G et al. · 2016
Researchers established seven groups of pregnant rats and exposed some to 900 MHz EMF for 60 minutes per day during the gestation period. After birth, male rat pups were selected and the total number of pyramidal neurons in the hippocampal region was counted using the optical fractionator technique. The total number of pyramidal cells in the EMF group was significantly lower than in the control, sham, EMF plus melatonin, and EMF plus omega-3 groups. No difference was observed between any groups in terms of rats' body or brain weights.
Mortazavi SM et al. · 2016
The study investigated the effects of radiofrequency radiation from GSM mobile phones on insulin release in rats. RF radiation did not alter insulin release in the rats. Mild to severe inflammatory changes in the portal spaces of the liver and damage to the cells of the islet of Langerhans were observed. The changes were linked to the duration of exposure.
Nakatani-Enomoto S et al. · 2016
Nakatani-Enomoto S et al. · 2016
Researchers exposed human sperm samples to cell phone-like radiation (1950 MHz) for one hour at two different power levels to see if it affected sperm movement or caused DNA damage. They found no significant changes in sperm motility, movement patterns, or DNA damage markers compared to unexposed samples. This study suggests that short-term exposure to this type of radiation may not immediately harm sperm function under controlled laboratory conditions.
Kumar G, McIntosh RL, Anderson V, McKenzie RJ, Wood AW. · 2015
The researchers extended a previous study by testing for effects at different SAR levels, both 900 and 1800 MHz, and both continuous wave and pulse modulated RF radiation. Excised long bones from rats were placed in medium and exposed to RF radiation in a transverse electromagnetic cell or a waveguide. Finite-difference time-domain numerical analyses were used to estimate the forward power needed to produce nominal SAR levels of 2/10 and 2.5/12.4 W/kg in the bone marrow. After exposure, lymphoblasts were extracted and assayed for proliferation rate and genotoxicity. No significant changes were observed in the hematopoietic system of rats after exposure to CW/PM wave 900 MHz/1800 MHz RF radiations at different SAR values.
Lustenberger et al. · 2015
Swiss researchers exposed 20 young men to cell phone-level radiation (900 MHz at 2 watts per kilogram) for 30 minutes before sleep on two separate nights, then monitored their brain activity throughout the night using EEG. While they found some increases in certain brain wave patterns during deep sleep, these effects were inconsistent - they didn't reliably occur in the same individuals across both exposure sessions. This suggests that if cell phone radiation affects sleep brain activity, the response varies unpredictably between people and even within the same person on different nights.
Kumar G, McIntosh RL, Anderson V, McKenzie RJ, Wood AW. · 2015
Researchers exposed rat bone marrow to mobile phone radiation at 900 and 1800 MHz frequencies to test for genetic damage and effects on blood cell production. They tested both continuous and pulsed signals at power levels ranging from 2 to 12.4 watts per kilogram. The study found no significant changes in cell growth or DNA damage in the bone marrow cells after exposure.
Zuo WQ, Hu YJ, Yang Y, Zhao XY, Zhang YY, Kong W, Kong WJ. · 2015
Researchers used spiral ganglion neurons from neonatal Sprague Dawley rats to investigate whether inflammation might increase sensitivity to damage from mobile phone electromagnetic radiation. Radiofrequency electromagnetic radiation alone could not directly induce DNA damage in normal spiral ganglion neurons. The study suggests that sensitivity of spiral ganglion neurons to damage caused by mobile phone electromagnetic radiation may increase in a lipopolysaccharide-induced inflammation model.
Masuda H et al. · 2015
The cortex tissue targeted was locally exposed to 1439 MHz RF using a figure-8 loop antenna at an averaged specific absorption rate of 2.0 W/kg in the target area for 50 min. Three microcirculatory parameters related to cerebral inflammation were measured by the cranial window method in real-time under RF exposure. No extravasation of intravenously injected fluorescent dye was observed during RF exposure. There was no significant difference either in pial venule blood flow velocity or diameter between exposed and sham-exposed rats. Histological evaluation for the brain immediately after RF exposure did not reveal any serum albumin leakage sites or degenerate neurons.
Lustenberger et al. · 2015
The study investigated how much variation exists between individuals and within the same individual in response to pulsed radiofrequency electromagnetic field exposure during sleep. The EEG analysis showed exposure-related increases in the delta-theta frequency range at several fronto-central electrodes, but no differences in the spindle frequency range. Reproducible within-subject effects on sleep spindle and delta-theta activity were not observed, and it remained unclear whether a biological trait of how subjects' brains react to RF EMF exists.
Zhang Y, Li Z, Gao Y, Zhang C. · 2015
Researchers investigated whether in utero exposure to 9.417-GHz microwave throughout gestation affected behavior in mouse offspring. Offspring showed less movement in the center of an open field and in an open arm of the elevated-plus maze, which the researchers interpreted as increased anxiety-related behavior. Offspring also showed reduced immobility in the tail suspension test and forced swimming test, which was interpreted as decreased depression-related behavior. In the Morris water maze, male offspring showed decreased learning and memory while female offspring were not affected, suggesting gender-dependent effects.
Hou Q, Wang M, Wu S, Ma X, An G, Liu H, Xie F · 2015
Researchers studied reactive oxygen species, DNA damage, and apoptosis in mouse embryonic fibroblasts (NIH/3T3) exposed to 1800-MHz GSM-talk mode electromagnetic radiation at an average specific absorption rate of 2 W/kg. Intracellular ROS levels increased significantly after exposure, reaching their highest level at one hour of exposure, then declining slightly with longer exposure up to eight hours. The percentage of late-apoptotic cells was significantly higher in the exposed group than in sham-exposed groups, while no significant effect on the DNA damage marker γH2AX was detected.
Danker-Hopfe H et al. · 2015
Researchers conducted a double-blind, randomized, sham-controlled cross-over study to examine whether electromagnetic fields from GSM 900 and WCDMA/UMTS devices affected sleep. Thirty healthy young men between 18 and 30 years old were each exposed three times per exposure condition while their sleep was recorded. The only consistent finding across individuals was an increase of stage R sleep under GSM 900 MHz exposure in 9 of 30 subjects and under WCDMA/UMTS exposure in 10 of 30 subjects.
Kang KA et al. · 2014
Researchers exposed U87, PC12, and SH-SY5Y neuronal cells to combined radiofrequency radiation at 837 MHz CDMA and 1950 MHz WCDMA with a specific absorption rate of 2 W/kg each for 2 hours. They also tested co-exposure with hydrogen peroxide or menadione and measured intracellular reactive oxygen species using flow cytometry with a fluorescent probe. Combined RF radiation alone did not consistently affect ROS levels in a time-dependent manner, and co-exposure with hydrogen peroxide or menadione showed no statistically significant change compared to the chemicals alone.
