Loughran SP, McKenzie RJ, Jackson ML, Howard ME, Croft RJ. · 2012
Twenty volunteers each underwent two experimental nights in which they were randomly exposed to either an active or sham condition before a full night of sleep. EEG spectral power was increased in the sleep spindle frequency range in the first 30 minutes of non-REM sleep after active exposure. The increase was more prominent in participants who had already shown an increase in the original study, suggesting the effect is sensitive to individual variability.
Fragopoulou AF et al. · 2012
Researchers investigated the effects of two sources of electromagnetic fields on the proteome of the cerebellum, hippocampus, and frontal lobe in Balb/c mice following long-term whole body irradiation. Across both exposure types, 143 proteins showed significantly altered expression, ranging from as low as 0.003 fold downregulation up to 114 fold overexpression. The altered proteins included neural function related proteins, heat shock proteins, cytoskeletal proteins, and proteins of brain metabolism across nearly all brain regions studied.
Thomée S, Härenstam A, Hagberg M. · 2011
The study included 4156 young adults aged 20-24 who completed questionnaires at baseline and 1-year follow-up. Mobile phone exposure variables included frequency of use and qualitative aspects such as demands on availability, perceived stressfulness of accessibility, being awakened at night, and personal overuse. Cross-sectionally, high mobile phone use was linked to stress, sleep disturbances, and depression symptoms in both sexes; prospectively, high use predicted sleep disturbances and depression symptoms in men and depression symptoms in women, while overuse predicted stress and sleep disturbances in women and high accessibility stress predicted stress, sleep disturbances, and depression symptoms in both sexes.
Kumar S, Kesari KK, Behari J. · 2011
Researchers exposed male Wistar rats to a 2.45 GHz microwave field for two hours per day over 60 days. They also applied a 100 Hz pulsed electromagnetic field to some groups, either alone or combined with the microwave exposure. Microwave exposure significantly increased caspase and creatine kinase levels and decreased testosterone and melatonin. Pulsed electromagnetic field exposure relieves the effect of microwave exposure by inducing Faraday currents.
Chaturvedi CM et al. · 2011
Lowden A et al. · 2011
Researchers investigated the effects of a double-blind radiofrequency exposure on sleepiness and EEG measures during sleep. Forty-eight subjects with a mean age of 28 years underwent three hours of controlled exposure prior to sleep, followed by a full-night polysomnographic recording in a sleep laboratory. Following exposure, slow-wave sleep decreased by 9.5 minutes and the latency to Stage 3 sleep was prolonged by 4.8 minutes compared to sham. No differences were found between subjects who had previously reported mobile phone-related symptoms and those who had not.
Kesari KK, Kumar S, Behari J. · 2011
Researchers exposed 35-day old Wistar rats to a mobile phone for 2 hours per day for 45 days at a specific absorption rate of 0.9 W/Kg. Animals were divided into a sham exposed group and an exposed group, each with 6 animals. The exposed group showed a significant decrease in glutathione peroxidase and superoxide dismutase, and a significant increase in reactive oxygen species. The researchers concluded that these findings on biomarkers are clear indications of possible health implications.
Mohler E et al. · 2010
Researchers assessed self-reported sleep disturbances and daytime sleepiness in a random sample of 1,375 residents of Basel, Switzerland. Environmental far-field RF EMF exposure was predicted for each individual using a validated prediction model, and mobile and cordless phone use were also considered. Multivariable regression models adjusted for confounders showed no association between far-field RF EMF exposure and sleep disturbances or excessive daytime sleepiness. The 10% most exposed participants had an estimated risk for sleep disturbances of 1.11 (95% CI: 0.50 to 2.44) and for excessive daytime sleepiness of 0.58 (95% CI: 0.31 to 1.05). Neither mobile phone use nor cordless phone use was associated with decreased sleep quality.
Danker-Hopfe H, Dorn H, Bornkessel C, Sauter C. · 2010
Researchers conducted a double-blind, sham-controlled, randomized cross-over study with 397 residents exposed to GSM base station signals and sham exposure at home for 12 nights. No significant differences in objective or subjective sleep measures were found between real and sham exposure conditions. During sham exposure nights, participants with concerns about health risks from base stations had significantly worse sleep efficiency, wake after sleep onset, and subjective sleep latency than those without concerns. The authors concluded that EMF from base stations did not affect sleep quality, but the presence of base stations themselves may negatively impact sleep.
Hardell L, Söderqvist F, Carlberg M, Zetterberg H, Mild KH · 2010
Researchers studied the concentration of β-trace protein in blood in relation to emissions from wireless phones in 62 persons aged 18-30 years. The concentration of β-trace protein decreased with increasing number of years of use of a wireless phone, yielding a negative β coefficient of -0.32 with a 95% confidence interval of -0.60 to -0.04. Cumulative use in hours also gave a negative β coefficient, although not statistically significant. Forty of the 62 persons participated in an experimental study with 30 min exposure to an 890-MHz GSM signal, and no statistically significant change of β-trace protein was found. In a similar study of the remaining 22 participants with no exposure, β-trace protein increased significantly over time, probably due to a relaxed situation.
Danker-Hopfe H, Dorn H, Bahr A, Anderer P, Sauter C. · 2010
Mannerling AC, Simkó M, Mild KH, Mattsson MO · 2010
Researchers exposed human K562 leukemia cells to a 50-Hz sine-wave magnetic field for 1 hour at flux densities ranging from 0.025 to 0.10 mT, measuring proliferation, cell cycle distribution, superoxide radical anion levels, and HSP70 protein levels. Both vertical and horizontal exposures caused significantly and transiently increased HSP70 levels of more than twofold at several flux densities, compared to sham controls and also compared to a heat-treatment positive control. Superoxide radical anion levels increased by 30–40%, and adding free radical scavengers melatonin or 1,10-phenantroline inhibited the magnetic-field-induced increase in HSP70. Cell cycle kinetics and proliferation were not affected by exposure at 0.10 mT for 1 hour.
Xu S et al. · 2010
Researchers exposed primary cultured cortical neurons to pulsed radiofrequency electromagnetic fields at 1800 MHz modulated by 217 Hz at an average specific absorption rate of 2 W/kg. At 24 hours after exposure, researchers found a significant increase in levels of 8-hydroxyguanine, a common biomarker of DNA oxidative damage, in the mitochondria of neurons. The copy number of mitochondrial DNA and the levels of mitochondrial RNA transcripts showed an obvious reduction after RF exposure. Each of these mitochondrial DNA disturbances could be reversed by pretreatment with melatonin.
Landgrebe M, Frick U, Hauser S, Hajak G, Langguth B. · 2009
The study used a case-control design with 89 electromagnetic hypersensitive patients and 107 matched controls to assess tinnitus occurrence and severity by questionnaires. Tinnitus was significantly more frequent in the electromagnetic hypersensitive group (50.72% vs. 17.5%) while tinnitus duration and severity did not differ between groups. Electromagnetic hypersensitivity and tinnitus were independent risk factors for sleep disturbances, but measures of individual EMF exposure like cell phone use did not show any association with tinnitus.
Berg-Beckhoff G et al. · 2009
Researchers conducted a cross-sectional study in 2006 with 3526 participants living mainly in urban regions to test whether low-level RF-EMF from mobile phone base stations was related to health disturbances. Exposure was assessed with a dosimeter measuring different RF-EMF frequencies, and health outcomes were collected via postal questionnaires on sleep disturbances, headaches, health complaints, and mental and physical health. No differences in median health scores were found between exposed and non-exposed participants, and measured RF-EMFs were not associated with adverse health effects.
Cvetkovic D, Cosic I. · 2009
Researchers tested whether a series of extremely low frequency magnetic field exposures at 50, 16.66, 13, 10, 8.33, and 4 Hz could alter relative power within corresponding brainwave bands. Thirty-three human subjects were tested under double-blind and counter-balanced conditions. Narrow alpha1 and alpha2 bands were significantly lower than control over temporal and parietal regions during the first exposure session, then significantly higher than control during the second session. The beta1 band showed a significant increase from before to after the 13 Hz first exposure session at the frontal region.
Lerchl A et al. · 2008
Researchers exposed adult male Djungarian hamsters to RF-EMF at 383, 900, and 1800 MHz for 60 days at 80 mW/kg. Pineal and serum melatonin levels and organ weights were not affected in any experiment. Body weight increased transiently up to 4% at 383 MHz, increased up to 6% non-transiently at 900 MHz, and was unchanged at 1800 MHz.
Djeridane Y, Touitou Y, de Seze R. · 2008
Researchers exposed 20 healthy men to 900 MHz GSM radiation from a cellular phone for 2 hours per day, 5 days per week, for 4 weeks. Blood samples were taken hourly at night and every 3 hours during the day across four sessions spaced 15 days apart, using each man's pre-exposure levels as his control. All hormone levels stayed within normal ranges, and circadian patterns of prolactin, thyroid-stimulating hormone, adrenocorticotropin, and testosterone were not disrupted, while growth hormone and cortisol maximum levels decreased significantly during exposure but returned to baseline afterward.
Soderqvist F, Carlberg M, Hardell L. · 2008
The aim of the study was to assess wireless phone use and its relation to explanatory factors and self-reported health symptoms. A postal questionnaire with 27 questions and 75 items was sent to 2000 Swedish adolescents aged 15-19 years selected from the population registry using a stratified sampling scheme, and 63.5% of the study subjects answered it. Most participants reported access to a mobile phone (99.6%) and use increased with age; 55.6% of 15-year-olds and 82.2% of 19-year-olds were regular users, girls generally reported more frequent use than boys, and watching TV increased the odds ratio for wireless phone use adjusted for age and gender. Regular users of wireless phones had health symptoms more often and reported poorer perceived health than less frequent users.
Khan MM. · 2008
Researchers surveyed medical students using a questionnaire about mobile phone use and health complaints. The response rate was 86.6% with 286 of 330 forms completed. Most students (83.57%) had some knowledge about adverse effects of mobile phone use. Daily mobile phone use was less than 30 minutes for 55.94% of students, 30-60 minutes for 27.97%, 60-90 minutes for 11.53%, and more than 90 minutes for 4.54%. Reported symptoms included headache (16.08%), fatigue (24.48%), impaired concentration (34.27%), memory disturbances (40.56%), sleeplessness (38.8%), hearing problems (23.07%), facial dermatitis (16.78%), and a sensation of warmth in the ear area (28.32%); 44.4% of the 286 subjects linked their symptoms to mobile phone use.
Perentos N, Croft RJ, McKenzie RJ, Cvetkovic D, Cosic I. · 2008
Researchers investigated the effect of GSM-like ELF radiation on the alpha band of the human resting EEG. The study used a fully counterbalanced, double-blind, cross-over design with 72 healthy volunteers. A decrease in the alpha frequency band was observed during 20 minutes of ELF exposure in the exposed hemisphere only.
Sokolovic D et al. · 2008
Researchers exposed Wistar rats to microwave radiation from a mobile test phone for 20, 40, and 60 days to evaluate oxidative stress in brain tissue and whether melatonin could reduce it. Exposure led to a significant increase in malondialdehyde and carbonyl group concentrations in brain tissue, along with decreased catalase activity and increased xanthine oxidase activity. Melatonin treatment significantly prevented the rise in MDA content and xanthine oxidase activity after 40 days of exposure, but was unable to prevent the decrease in catalase activity or the increase in carbonyl group content.
Schmid G et al. · 2007
Researchers measured the dielectric properties of 20 freshly removed human pineal glands less than 20 hours after death. They developed a high-resolution numerical model of the brain region around the pineal gland based on a real human tissue sample. FDTD computations were performed for handheld device exposures close to the head at 400-1850 MHz. The highest absorption was at 400 MHz with 11 microW absorbed in a 96 mg gland from a 500 mW device. At 900 MHz and 1850 MHz, absorption was lower by factors of 4.2 and 36 respectively.
Fritzer G et al. · 2007
Clark ML et al. · 2007
Researchers measured estrogen and melatonin metabolites in overnight urine from women living near radio and television transmitters. Among premenopausal women, no associations were found between RF or 60-Hz exposure and either metabolite.
