3,138 Studies Reviewed. 77.4% Found Biological Effects. The Evidence is Clear.
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Immune System

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Key Finding: 77% of 274 studies on immune system found biological effects from EMF exposure.

Of 274 studies examining immune system, 77% found measurable biological effects from EMF exposure.

Lowest Documented Effect

Research found effects on immune system at exposures as low as:

Study Exposure Level in ContextA logarithmic scale showing exposure levels relative to Building Biology concern thresholds and regulatory limits.Study Exposure Level in Context0.00000052, 0.00001536, 0.00021268Extreme Concern1,000 uW/m2FCC Limit10M uW/m2Effects observed in the No Concern range (Building Biology)FCC limit is 19,230,769,230,769x higher than this exposure level

Research Overview

  • -When 106 out of 129 studies (82.2%) document immune system effects from electromagnetic field exposure, we're looking at one of the most consistently demonstrated biological impacts of EMF.
  • -The science demonstrates that your body's natural defense system responds to wireless radiation in ways that can compromise your ability to fight infections, heal from injuries, and maintain optimal health.
  • -Research has documented a range of immune system disruptions, from reduced white blood cell counts and altered antibody production to increased inflammatory markers and compromised cellular repair mechanisms.

When 106 out of 129 studies (82.2%) document immune system effects from electromagnetic field exposure, we're looking at one of the most consistently demonstrated biological impacts of EMF. The science demonstrates that your body's natural defense system responds to wireless radiation in ways that can compromise your ability to fight infections, heal from injuries, and maintain optimal health.

While we don't yet have as many studies specifically examining EMF effects on immune function as we do for other biological systems, the evidence that does exist points to concerning patterns.

Importantly, many effects occur at exposure levels below those causing significant body temperature increases, with some studies showing responses at specific absorption rates as low as 0.14 W/kg.

Source: BioInitiative Working Group. BioInitiative Report: A Rationale for Biologically-based Public Exposure Standards for Electromagnetic Radiation. Edited by Cindy Sage and David O. Carpenter, BioInitiative, 2012, updated 2020. www.bioinitiative.org

Showing 274 studies

The effects of 2100-MHz radiofrequency radiation on nasal mucosa and mucociliary clearance in rats.

Aydoğan F et al. · 2015

Researchers exposed rats to 2100 MHz radiofrequency radiation (simulating 3G cell phone signals) for 6 hours daily over 10 or 40 days to study effects on nasal tissue and mucus clearance. The exposed rats showed significant damage to nasal tissue, including cell death, loss of protective cilia (tiny hair-like structures), and impaired ability to clear mucus from nasal passages. This matters because our nasal passages are a primary defense against airborne pathogens, and cell phone radiation may be compromising this natural protective mechanism.

Effect of 900 MHz Electromagnetic Radiation on the Induction of ROS in Human Peripheral Blood Mononuclear Cells.

Kazemi E et al. · 2015

Researchers exposed blood cells from 13 healthy volunteers to 900 MHz radiation (the frequency used by cell phones) for 2 hours and measured cellular damage. They found that exposure significantly increased reactive oxygen species (ROS) - harmful molecules that damage cells - in monocytes, a type of immune cell. This suggests that cell phone radiation can trigger oxidative stress in immune system cells.

Can prenatal exposure to a 900 MHz electromagnetic field affect the morphology of the spleen and thymus, and alter biomarkers of oxidative damage in 21-day-old male rats?

Hancı H et al. · 2015

Researchers exposed pregnant rats to 900 MHz cell phone radiation for one hour daily and examined the immune organs (spleen and thymus) of their male offspring at 21 days old. The prenatal radiation exposure caused significant oxidative damage and structural abnormalities in these critical immune system organs. This suggests that EMF exposure during pregnancy may compromise immune system development in offspring.

Immune SystemNo Effects Found

Effects of 21-kHz intermediate frequency magnetic fields on blood properties and immune systems of juvenile rats.

Ushiyama A et al. · 2014

Researchers exposed young rats to 21-kHz magnetic fields (similar to frequencies used in induction heating and some wireless charging) for one hour daily over two weeks to test effects on blood and immune system function. The study found no significant changes in immune cell activity, blood cell counts, or other immune markers, with only a minor phosphorus level change that remained within normal ranges. This suggests that short-term exposure to these intermediate-frequency magnetic fields may not substantially impact immune function in developing animals.

Non-linear adaptive phenomena which decrease the risk of infection after pre-exposure to radiofrequency radiation.

Mortazavi SM et al. · 2014

Researchers exposed mice to radiofrequency radiation from a GSM mobile phone, then infected them with E. coli bacteria to test their immune response. They found that pre-exposure to RF radiation dramatically improved survival rates - 56% of pre-exposed mice survived the bacterial infection compared to only 20% of unexposed mice. This suggests RF radiation may trigger an adaptive response that strengthens the immune system's ability to fight off infections.

Differential Pro-Inflammatory Responses of Astrocytes and Microglia Involve STAT3 Activation in Response to 1800 MHz Radiofrequency Fields.

Lu Y et al. · 2014

Researchers exposed brain immune cells (microglia and astrocytes) to 1800 MHz radiofrequency radiation - the same frequency used by many cell phones. They found that RF exposure triggered inflammatory responses in both cell types, but through different biological pathways. The study identified a specific protein (STAT3) that could be targeted to potentially protect against RF-induced brain inflammation.

A new problem in inflammatory bladder diseases: Use of mobile phones!

Koca O, Gokce AM, Akyuz M, Ercan F, Yurdakul N, Karaman MI. · 2014

Turkish researchers exposed laboratory rats to mobile phone radiation for 8 hours daily over 20 days and examined their bladder tissue under a microscope. They found severe inflammation in the bladder's inner layers in exposed rats, with inflammation scores nearly five times higher than unexposed controls. The study suggests that intensive mobile phone use may contribute to bladder inflammation and related urinary problems.

Effect of mobile phone use on salivary concentrations of protein, amylase, lipase, immunoglobulin A, lysozyme, lactoferrin, peroxidase and C-reactive protein of the parotid gland.

Hashemipour MS, Yarbakht M, Gholamhosseinian A, Famori H. · 2014

Researchers examined saliva from 86 people to see if mobile phone use affected the parotid glands (major salivary glands near the ears). They found that people who predominantly held phones on their right side had higher protein levels and saliva flow on that same side, while levels of important enzymes like amylase and lysozyme decreased. This suggests that radiofrequency radiation from phones may alter the normal function of salivary glands closest to where the phone is held.

Hsp70 is an independent stress marker among frequent users of mobile phones.

Balakrishnan K et al. · 2014

Researchers compared blood markers between 120 heavy mobile phone users (IT professionals) and 102 light users to see if phone radiation triggers stress responses in the body. They found significantly elevated levels of heat shock protein 70 (HSP70) and C-reactive protein (CRP) in heavy users, indicating cellular stress and inflammation. This suggests that frequent mobile phone use may activate biological stress pathways that could potentially impact health over time.

Metabolic and genetic screening of electromagnetic hypersensitive subjects as a feasible tool for diagnostics and intervention.

De Luca C et al. · 2014

Italian researchers analyzed blood samples from 153 people with electromagnetic hypersensitivity (EHS) and found distinctive metabolic changes including increased oxidative stress and specific genetic variations. These blood markers could potentially serve as diagnostic tools to identify EHS as a legitimate medical condition.

Effect of a 2.45-GHz radiofrequency electromagnetic field on neutrophil chemotaxis and phagocytosis in differentiated human HL-60 cells.

Koyama S et al. · 2014

Japanese researchers exposed immune cells called neutrophils to 2.45-GHz radiofrequency radiation (the same frequency used in WiFi and microwave ovens) at levels up to 10 W/kg for up to 24 hours. They found no significant effects on the cells' ability to migrate toward threats or engulf harmful particles - two critical immune functions. This suggests that RF exposure at current safety limits may not impair these specific immune responses.

In vivo analysis of THz wave irradiation induced acute inflammatory response in skin by laser-scanning confocal microscopy.

Hwang Y, Ahn J, Mun J, Bae S, Jeong YU, Vinokurov NA, Kim P. · 2014

Researchers exposed mouse ear skin to terahertz (THz) radiation at 2.7 THz frequency for 30 minutes and monitored the immune response using advanced microscopy. They found that THz exposure triggered a massive inflammatory response, with immune cells called neutrophils flooding into the exposed skin area within 6 hours. Importantly, this inflammatory reaction occurred without any detectable heating of the skin, suggesting the radiation caused biological effects through non-thermal mechanisms.

Modifying Effects of Low-Intensity Extremely High-Frequency Electromagnetic Radiation on Content and Composition of Fatty Acids in Thymus of Mice Exposed to X-Rays.

Gapeyev AB, Aripovsky AV, Kulagina TP. · 2014

Scientists exposed mice to 42.2 GHz electromagnetic radiation to test whether it could protect against X-ray damage to immune tissue. The electromagnetic exposure helped restore normal tissue chemistry and weight in the thymus gland, suggesting certain frequencies might aid immune system recovery from radiation injury.

The morphological and molecular changes of brain cells exposed to direct current electric field stimulation.

Pelletier SJ et al. · 2014

Researchers exposed brain cells to direct current electric fields at different intensities to see how they would respond. They found that neurons grew longer and changed shape, immune cells called microglia became more inflammatory, and support cells called astrocytes also changed their structure. This study helps explain how electric fields can directly alter brain cell behavior and function.

Differential Pro-Inflammatory Responses of Astrocytes and Microglia Involve STAT3 Activation in Response to 1800 MHz Radiofrequency Fields.

Lu Y et al. · 2014

Researchers exposed brain cells to 1,800 MHz cell phone radiation and found it triggered inflammation in both microglia and astrocytes, but through different biological pathways. The study identified how radiofrequency exposure activates specific proteins that release inflammatory chemicals, potentially explaining brain inflammation from cell phone use.

DNA & Genetic DamageNo Effects Found

Influence of GSM Signals on Human Peripheral Lymphocytes: Study of Genotoxicity.

Waldmann P et al. · 2013

Researchers exposed human blood cells from 40 volunteers to cell phone radiation (1,800 MHz) for 28 hours at three different intensities and tested for DNA damage using multiple methods. The study found no evidence that the radiation caused genetic damage to the cells at any exposure level. This collaborative study across six independent laboratories used rigorous controls and blinded analysis to ensure reliable results.

Effects of low amplitude pulsed radiofrequency stimulation with different waveform in rats for neuropathic pain.

Lin WT, Chang CH, Cheng CY, Chen MC, Wen YR, Lin CT, Lin CW. · 2013

Researchers tested how different types of pulsed radiofrequency (RF) signals affect pain relief in rats with nerve damage. They found that sinusoidal (smooth wave) RF signals provided better pain relief than square wave signals when applied to nerve clusters at the spine. The study also measured inflammatory markers in spinal tissue to understand how RF treatment reduces pain responses.

Changes in antioxidant capacity of blood due to mutual action of electromagnetic field (1800 MHz) and opioid drug (tramadol) in animal model of persistent inflammatory state.

Bodera P et al. · 2013

Researchers exposed rats to cell phone radiation at 1800 MHz (the same frequency used by GSM phones) for 15 minutes and measured changes in their blood's antioxidant capacity. They found that this brief exposure significantly reduced the blood's ability to neutralize harmful free radicals, both in healthy rats and those with inflammation. The study also tested interactions with tramadol (a pain medication) and found the radiation effects were amplified when combined with the drug.

The effect of electromagnetic radiation on the rat brain: an experimental study.

Eser O et al. · 2013

Turkish researchers exposed rats to radiofrequency radiation at cell phone frequencies (900, 1800, and 2450 MHz) for one hour daily over two months. They found severe brain damage including cell death and shrunken brain tissue in key areas like the frontal cortex and brain stem, along with increased oxidative stress and inflammation. This demonstrates that chronic RF exposure can cause structural brain damage even at relatively low daily exposure levels.

Changes in antioxidant capacity of blood due to mutual action of electromagnetic field (1800 MHz) and opioid drug (tramadol) in animal model of persistent inflammatory state

Bodera P et al. · 2013

Researchers exposed rats to cell phone radiation (1800 MHz) for 15 minutes and found it significantly reduced the blood's ability to fight harmful free radicals. This antioxidant damage occurred in both healthy and inflamed animals, suggesting cell phone radiation may weaken natural cellular defenses.

Exposure of tumor-bearing mice to extremely high-frequency electromagnetic radiation modifies the composition of fatty acids in thymocytes and tumor tissue.

Gapeyev AB, Kulagina TP, Aripovsky AV. · 2013

Researchers exposed mice with cancer to extremely high-frequency electromagnetic radiation (42.2 GHz) for 20 minutes daily and found it changed the fatty acid composition in their tissues. The radiation appeared to restore normal fatty acid levels in immune system cells (thymocytes) and altered the fatty acid makeup within tumor tissue itself. This suggests EMF exposure might influence cancer progression by changing how cells process fats.

The effect of electromagnetic field on reactive oxygen species production in human neutrophils in vitro.

Poniedzialek B et al. · 2013

Polish researchers exposed human immune cells called neutrophils to extremely low frequency magnetic fields at three different strengths (10, 40, and 60 microTesla) to see how it affected their production of reactive oxygen species - molecules that can damage cells. They found that only magnetic fields tuned to a specific frequency that affects calcium ions could change how these immune cells behaved, with the effect depending on the field strength.

Learn More

For a comprehensive exploration of EMF health effects including immune system, along with practical protection strategies, explore these books by R Blank and Dr. Martin Blank.

FAQs: EMF & Immune System

When 106 out of 129 studies (82.2%) document immune system effects from electromagnetic field exposure, we're looking at one of the most consistently demonstrated biological impacts of EMF. The science demonstrates that your body's natural defense system responds to wireless radiation in ways that can compromise your ability to fight infections, heal from injuries, and maintain optimal health.
The BioInitiative Report database includes 274 peer-reviewed studies examining the relationship between electromagnetic field exposure and immune system. These studies have been conducted by researchers worldwide and published in scientific journals. The research spans multiple decades and includes various types of EMF sources including cell phones, WiFi, power lines, and other common sources of electromagnetic radiation.
77% of the 274 studies examining immune system found measurable biological effects from EMF exposure. This means that 210 studies documented observable changes in biological systems when exposed to electromagnetic fields. The remaining 23% either found no significant effects or had inconclusive results, which is typical in scientific research where study design and exposure parameters vary.