3,138 Studies Reviewed. 77.4% Found Biological Effects. The Evidence is Clear.
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Immune System

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Key Finding: 77% of 274 studies on immune system found biological effects from EMF exposure.

Of 274 studies examining immune system, 77% found measurable biological effects from EMF exposure.

Lowest Documented Effect

Research found effects on immune system at exposures as low as:

Study Exposure Level in ContextA logarithmic scale showing exposure levels relative to Building Biology concern thresholds and regulatory limits.Study Exposure Level in Context0.00000052, 0.00001536, 0.00021268Extreme Concern1,000 uW/m2FCC Limit10M uW/m2Effects observed in the No Concern range (Building Biology)FCC limit is 19,230,769,230,769x higher than this exposure level

Research Overview

  • -When 106 out of 129 studies (82.2%) document immune system effects from electromagnetic field exposure, we're looking at one of the most consistently demonstrated biological impacts of EMF.
  • -The science demonstrates that your body's natural defense system responds to wireless radiation in ways that can compromise your ability to fight infections, heal from injuries, and maintain optimal health.
  • -Research has documented a range of immune system disruptions, from reduced white blood cell counts and altered antibody production to increased inflammatory markers and compromised cellular repair mechanisms.

When 106 out of 129 studies (82.2%) document immune system effects from electromagnetic field exposure, we're looking at one of the most consistently demonstrated biological impacts of EMF. The science demonstrates that your body's natural defense system responds to wireless radiation in ways that can compromise your ability to fight infections, heal from injuries, and maintain optimal health.

While we don't yet have as many studies specifically examining EMF effects on immune function as we do for other biological systems, the evidence that does exist points to concerning patterns.

Importantly, many effects occur at exposure levels below those causing significant body temperature increases, with some studies showing responses at specific absorption rates as low as 0.14 W/kg.

Source: BioInitiative Working Group. BioInitiative Report: A Rationale for Biologically-based Public Exposure Standards for Electromagnetic Radiation. Edited by Cindy Sage and David O. Carpenter, BioInitiative, 2012, updated 2020. www.bioinitiative.org

Showing 274 studies

Immune SystemNo Effects Found

Prenatal exposure to radiofrequencies: Effects of WiFi signals on thymocyte development and peripheral T cell compartment in an animal model.

Laudisi F et al. · 2012

Italian researchers exposed pregnant mice to WiFi signals (2.45 GHz) at high levels for 2 hours daily throughout pregnancy to study effects on their offspring's immune system development. They found no detrimental effects on T cell development, immune cell counts, or immune function in the offspring at either 5 weeks or 26 weeks of age. This suggests that prenatal WiFi exposure may not harm developing immune systems, though the study used exposure levels much higher than typical human exposure.

Occupational exposure of dentists to electromagnetic fields produced by magnetostrictive cavitrons alters the serum cortisol level

Mortazavi SM et al. · 2012

Iranian researchers studied 41 dentists and dental students, comparing cortisol levels (a stress hormone) between those who used magnetostrictive dental scalers and those who didn't. They found that dentists exposed to the electromagnetic fields from these common dental tools had significantly lower cortisol levels by the end of their workday. This matters because cortisol helps regulate blood pressure, cardiovascular function, and immune system response, so chronically low levels could affect health.

Cellular Effects102 citations

Increased Radioresistance to Lethal Doses of Gamma Rays in Mice and Rats after Exposure to Microwave Radiation Emitted by a GSM Mobile Phone Simulator.

Mortazavi S et al. · 2012

Researchers exposed mice and rats to microwave radiation from a GSM mobile phone simulator for several days, then subjected them to lethal doses of gamma radiation. Animals that received microwave pre-exposure showed significantly higher survival rates compared to those that didn't. This suggests that microwave radiation can trigger an adaptive response that helps protect cells against subsequent radiation damage.

Inhibitory Effects of Microwave Radiation on LPS-Induced NFκB Expression in THP-1 Monocytes.

Li CY, Liao MH, Lin CW, Tsai WS, Huang CC, Tang TK. · 2012

Researchers exposed immune cells (monocytes) to 2450 MHz microwave radiation - the same frequency used in microwave ovens and Wi-Fi - and found it suppressed their normal inflammatory response. When these cells were stimulated to trigger inflammation, microwave exposure reduced their production of NFκB, a key protein that regulates immune function. This suggests microwave radiation can interfere with your immune system's ability to respond properly to threats.

Influence of Electromagnetic Radiation Produced by Mobile Phone on Some Biophysical Blood Properties in Rats.

El-Bediwi AB, Saad M, El-Kott AF, Eid E. · 2012

Researchers exposed rats to electromagnetic radiation from mobile phones and examined what happened to their blood. They found that the radiation damaged blood cells (red blood cells, white blood cells, and platelets) and made the blood thicker and more viscous. These changes could potentially affect blood circulation and overall health.

Electromagnetic fields instantaneously modulate nitric oxide signaling in challenged biological systems.

Pilla AA. · 2012

Researchers exposed cells to pulsed radiofrequency electromagnetic fields and found they immediately triggered a nearly 3-fold increase in nitric oxide production within seconds. Nitric oxide is a crucial signaling molecule that helps regulate blood flow, immune responses, and healing processes in the body. This study provides the first real-time evidence that non-thermal EMF exposure can rapidly alter this important cellular signaling pathway.

Induction of an adaptive response in human blood lymphocytes exposed to radiofrequencyfields: influence of the universal mobile telecommunication system (UMTS) signal and the specific absorption rate.

Zeni O et al. · 2012

Researchers exposed human immune cells (lymphocytes) to 3G cell phone radiation at various power levels for 20 hours, then treated them with a DNA-damaging chemical. They discovered that cells pre-exposed to radiation at 0.3 watts per kilogram showed less genetic damage than unexposed cells, suggesting the radiation triggered protective mechanisms. This adaptive response indicates that low-level radiofrequency exposure may prime cells to better defend against subsequent toxic challenges.

Mobile phone radiation interferes laboratory immunoenzymometric assays: Example chorionic gonadotropin assays.

Shahbazi-Gahrouei D et al. · 2012

Researchers tested whether cell phone radiation interferes with laboratory blood tests that measure pregnancy hormones (chorionic gonadotropin). They exposed blood samples to 900MHz radiation from two phones with different power levels and found that the radiation significantly altered the test results, especially at higher concentrations and stronger radiation levels. This suggests that cell phones could interfere with important medical tests in hospital laboratories.

Microwave radiation induced oxidative stress, cognitive impairment and inflammation in brain of Fischer rats.

Megha K et al. · 2012

Researchers exposed rats to cell phone-level microwave radiation (900 MHz and 1800 MHz) for 2 hours daily over 30 days and measured brain effects. The exposed rats showed significant cognitive impairment, increased brain inflammation, and oxidative stress (cellular damage from unstable molecules) compared to unexposed rats. This suggests that chronic microwave exposure at levels similar to cell phone use may harm brain function and memory.

Effects of 900MHz radiofrequency on corticosterone, emotional memory and neuroinflammation in middle-aged rats.

Bouji M, Lecomte A, Hode Y, de Seze R, Villégier AS. · 2012

French researchers exposed young and middle-aged rats to cell phone radiation (900 MHz) for 15 minutes to study brain effects. They found that older rats showed increased brain inflammation and enhanced emotional memory, while younger rats had elevated stress hormones. The study reveals that age significantly affects how the brain responds to radiofrequency radiation.

In utero and early-life exposure of rats to a Wi-Fi signal: screening of immune markers in sera and gestational outcome.

Aït-Aïssa S et al. · 2012

French researchers exposed pregnant rats and their newborn pups to Wi-Fi signals (2.45 GHz) for two hours daily during pregnancy and early life, then tested the young rats' blood for immune system markers and signs of developmental problems. They found no changes in immune responses or reproductive development at any exposure level tested, including levels much higher than typical human exposure to Wi-Fi.

Evaluation of inflammatory biomarkers associated with oxidative stress and histological assessment of magnetic therapy on experimental myopathy in rats.

Vignola MB et al. · 2012

Researchers exposed rats with muscle inflammation to pulsed electromagnetic fields (PEMF) at 20 mT and 50 Hz for 30 minutes daily over 8 days. The PEMF treatment significantly reduced inflammatory markers and oxidative stress indicators while promoting muscle healing. This suggests that specific electromagnetic field exposures may have therapeutic benefits for muscle injuries, though the high field strength used is much greater than typical environmental exposures.

Electromagnetic fields instantaneously modulate nitric oxide signaling in challenged biological systems.

Pilla AA · 2012

Researchers exposed brain cells to radiofrequency electromagnetic fields at 27.12 MHz and found the fields instantly triggered a nearly 3-fold increase in nitric oxide production. Nitric oxide is a crucial signaling molecule that helps regulate blood flow, immune responses, and healing processes in the body. The study shows that EMF exposure can immediately alter fundamental cellular communication pathways.

Activity of matrix metallo proteinases (MMPs) and the tissue inhibitor of MMP (TIMP)-1 in electromagnetic field-exposed THP-1 cells

Patruno A et al. · 2012

Researchers exposed immune cells to 50 Hz magnetic fields (the same frequency as power lines) for 24 hours and found significant disruption of cellular repair mechanisms. The EMF exposure caused oxidative stress and altered the activity of enzymes called matrix metalloproteinases (MMPs), which help regulate tissue repair and inflammation. These changes could potentially affect how the immune system responds to threats and repairs tissue damage.

Effects of 900 MHz radiofrequency on corticosterone, emotional memory and neuroinflammation in middle-aged rats

Bouji M, Lecomte A, Hode Y, de Seze R, Villégier AS · 2012

French researchers exposed young and middle-aged rats to 15 minutes of cell phone radiation (900 MHz) at high levels to study brain and stress responses. They found that middle-aged rats showed increased brain inflammation and enhanced emotional memory, while young rats had elevated stress hormone levels. The study reveals that age affects how the brain responds to radiofrequency exposure, with different vulnerabilities at different life stages.

Immune SystemNo Effects Found

Early life exposure to 2.45GHz WiFi-like signals: effects on development and maturation of the immune system

Sambucci M et al. · 2011

Italian researchers exposed newborn mice to WiFi-like signals (2.45 GHz) for 5 weeks during early development to see if young immune systems are more vulnerable to wireless radiation. They found essentially no effects on immune system development at either low (0.08 W/kg) or high (4 W/kg) exposure levels, with only one minor change in male mice at the higher level. The study suggests that developing immune systems may not be as sensitive to WiFi radiation as some have theorized.

Whole Body / GeneralNo Effects Found

One-year, simultaneous combined exposure of CDMA and WCDMA radiofrequency electromagnetic fields to rats.

Jin YB, Lee HJ, Seon Lee J, Pack JK, Kim N, Lee YS. · 2011

Researchers exposed rats to cell phone radiation from both CDMA and WCDMA technologies (the frequencies used by older 2G and 3G networks) for 45 minutes daily over one full year. The exposure levels were set at 4 W/kg total, which is four times higher than current safety limits. While most health measures remained normal, the study found some changes in blood chemistry and blood cell counts, though no increase in tumors or overall illness.

Induction of adaptive response in human blood lymphocytes exposed to 900 MHz radiofrequency fields: influence of cell cycle.

Sannino A et al. · 2011

Researchers exposed human immune cells (lymphocytes) to cell phone radiation at 1.25 W/kg for 20 hours, then tested how well the cells could protect themselves against a cancer-causing chemical. They found that cells exposed during their DNA-copying phase developed better defenses, while cells exposed during resting phases did not. This suggests that cell phone radiation may trigger protective responses in immune cells, but only when cells are actively dividing.

Genotoxic effects of 3 T magnetic resonance imaging in cultured human lymphocytes.

Lee JW, Kim MS, Kim YJ, Choi YJ, Lee Y, Chung HW. · 2011

Researchers exposed human immune cells (lymphocytes) to electromagnetic fields from clinical 3 Tesla MRI scanners for different time periods, from 22 to 89 minutes. They found that longer exposures caused increasing levels of DNA damage, including single-strand breaks and chromosome abnormalities. This suggests that the powerful electromagnetic fields used in high-strength MRI machines may pose genetic risks that increase with exposure time.

Mutagenic and morphologic impacts of 1.8GHz radiofrequency radiation on human peripheral blood lymphocytes (hPBLs) and possible protective role of pre-treatment with Ginkgo biloba (EGb 761)

Esmekaya MA et al. · 2011

Researchers exposed human immune cells to 1.8GHz cell phone radiation for up to 48 hours and found significant DNA damage and cellular destruction that worsened over time. Ginkgo biloba extract provided some protection, suggesting certain antioxidants might help reduce radiation-induced genetic damage in immune cells.

Induction of adaptive response: pre-exposure of mice to 900 MHz radiofrequency fields reduces hematopoietic damage caused by subsequent exposure to ionising radiation.

Cao Y, Xu Q, Jin ZD, Zhou Z, Nie JH, Tong J. · 2011

Chinese researchers found that mice exposed to cell phone radiation (900 MHz) for two weeks before receiving potentially lethal gamma radiation survived longer and showed less blood tissue damage. This suggests low-level radiofrequency exposure may activate protective cellular responses against subsequent radiation harm.

Learn More

For a comprehensive exploration of EMF health effects including immune system, along with practical protection strategies, explore these books by R Blank and Dr. Martin Blank.

FAQs: EMF & Immune System

When 106 out of 129 studies (82.2%) document immune system effects from electromagnetic field exposure, we're looking at one of the most consistently demonstrated biological impacts of EMF. The science demonstrates that your body's natural defense system responds to wireless radiation in ways that can compromise your ability to fight infections, heal from injuries, and maintain optimal health.
The BioInitiative Report database includes 274 peer-reviewed studies examining the relationship between electromagnetic field exposure and immune system. These studies have been conducted by researchers worldwide and published in scientific journals. The research spans multiple decades and includes various types of EMF sources including cell phones, WiFi, power lines, and other common sources of electromagnetic radiation.
77% of the 274 studies examining immune system found measurable biological effects from EMF exposure. This means that 210 studies documented observable changes in biological systems when exposed to electromagnetic fields. The remaining 23% either found no significant effects or had inconclusive results, which is typical in scientific research where study design and exposure parameters vary.