3,138 Studies Reviewed. 77.4% Found Biological Effects. The Evidence is Clear.
Research Guide

5G vs 4G Radiation: What's Different?

Based on 653 peer-reviewed studies

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People often ask whether 5G is more dangerous than 4G. This question requires understanding how 5G technology differs from previous generations and what research exists on each.

5G networks operate across multiple frequency bands. Low-band 5G (600-900 MHz) is actually similar to 4G frequencies. Mid-band 5G (2.5-4 GHz) overlaps with existing WiFi. High-band 5G (24-40+ GHz, "millimeter wave") represents the newest frequencies for consumer wireless exposure.

This page compares what research shows about radiation exposure from 5G versus 4G technologies.

Key Research Findings

  • 5G uses multiple frequency bands with different characteristics
  • Millimeter waves (high-band 5G) penetrate less deeply into tissue
  • More cell towers can actually reduce individual exposure levels

Related Studies (653)

Fifty hertz extremely low-frequency magnetic field exposure elicits redox and trophic response in rat-cortical neurons.

Di Loreto S et al. · 2009

Researchers exposed rat brain cells to 50 Hz magnetic fields and found the exposure improved cell survival and reduced cell death. The magnetic fields also triggered protective antioxidant responses and increased production of proteins that support brain health, suggesting potential protective effects.

Continuous exposure to 900MHz GSM-modulated EMF alters morphological maturation of neural cells

Del Vecchio G et al. · 2009

Italian researchers exposed developing brain cells to cell phone radiation at the same power level your phone uses during calls (1 W/kg SAR). The radiation significantly reduced the number of neural branches that normally grow as brain cells mature, suggesting cell phone signals may interfere with normal brain development. This finding raises concerns about wireless exposure during critical periods of brain development in children and adolescents.

Effect of radiofrequency electromagnetic field exposure on in vitro models of neurodegenerative disease

Del Vecchio G et al. · 2009

Italian researchers exposed brain cells to cell phone radiation (900 MHz GSM at 1 W/kg SAR) for 144 hours to see if it made them more vulnerable to damage. While the radiation alone didn't harm the cells, it made one type of brain cell significantly more vulnerable to damage from hydrogen peroxide, a common cellular toxin that causes oxidative stress.

Enhancement of chemically induced reactive oxygen species production and DNA damage in human SH-SY5Y neuroblastoma cells by 872MHz radiofrequency radiation.

Luukkonen J et al. · 2009

Researchers exposed human brain cells to radiofrequency radiation at 872 MHz (similar to older cell phone frequencies) combined with a chemical that creates cellular damage. They found that continuous wave RF radiation at high intensity (5 W/kg SAR) increased both harmful oxygen molecules and DNA damage compared to the chemical alone. Interestingly, pulsed signals like those used in GSM phones showed no such effects, even at the same power level.

Continuous exposure to 900MHz GSM-modulated EMF alters morphological maturation of neural cells.

Del Vecchio G et al. · 2009

Italian researchers exposed developing brain cells to cell phone radiation at levels similar to what phones emit (1 W/kg SAR at 900 MHz). They found that this radiation significantly reduced the growth of neurites - the branch-like extensions that neurons use to connect and communicate with each other. This suggests that cell phone radiation may interfere with normal brain cell development and connection formation.

Cellular EffectsNo Effects Found

Whole-body exposure of radiation emitted from 900 MHz mobile phones does not seem to affect the levels of anti-apoptotic bcl-2 protein.

Yilmaz F, Dasdag S, Akdag MZ, Kilinc N. · 2008

Researchers exposed rats to radiation from 900 MHz cell phones for 20 minutes daily for one month to see if it affected bcl-2, a protein that helps prevent cell death in the brain and testes. They found no changes in bcl-2 levels compared to unexposed rats. This suggests that at least for this specific cellular protection mechanism, short-term phone radiation exposure may not cause immediate harm to these organs.

DNA & Genetic DamageNo Effects Found

Evaluation of HSP70 Expression and DNA Damage in Cells of a Human Trophoblast Cell Line Exposed to 1.8 GHz Amplitude-Modulated Radiofrequency Fields.

Valbonesi P et al. · 2008

Researchers exposed human placental cells to cell phone radiation (1.8 GHz GSM signals) for one hour at levels twice the current safety limit to see if it would trigger cellular stress responses or DNA damage. The radiation exposure produced no detectable effects on stress proteins or DNA integrity, unlike positive control treatments that did cause measurable damage. This suggests that short-term exposure to this type of cell phone radiation may not immediately harm these particular cells.

Cellular EffectsNo Effects Found

Effect of GSM-900 and -1800 signals on the skin of hairless rats. III: Expression of heat shock proteins.

Sanchez S et al. · 2008

Researchers exposed hairless rats to cell phone radiation (GSM-900 and GSM-1800 signals) for up to 12 weeks to see if it would trigger heat shock proteins, which are cellular stress markers that indicate when cells are under strain. The study found no changes in these stress proteins at any exposure level tested, including levels up to 5 watts per kilogram. This suggests that under these experimental conditions, the cell phone radiation did not cause detectable cellular stress in rat skin.

Immune SystemNo Effects Found

Effects of GSM-modulated radiofrequency electromagnetic fields on mouse bone marrow cells.

Prisco MG et al. · 2008

Italian researchers exposed mice to cell phone radiation (900 MHz GSM signals) for 4 weeks, then transplanted their bone marrow cells into radiation-damaged mice to test if the EMF exposure affected the immune system's ability to rebuild itself. The bone marrow cells from EMF-exposed mice performed just as well as unexposed cells in rescuing the damaged mice and rebuilding their immune systems. This suggests that moderate cell phone radiation exposure doesn't impair the bone marrow's critical immune-building functions.

DNA & Genetic DamageNo Effects Found

Effects of modulated microwave radiation at cellular telephone frequency (1.95 GHz) on X-ray-induced chromosome aberrations in human lymphocytes in vitro.

Manti L et al. · 2008

Italian researchers exposed human blood cells to cell phone radiation (1.95 GHz UMTS signal) for 24 hours, then hit them with X-rays to see if the RF exposure made the radiation damage worse. While the cell phone signals didn't increase the number of damaged cells, they did cause a small but measurable increase in the severity of chromosome damage within each affected cell at the higher exposure level (2.0 W/kg SAR). This suggests RF radiation might interfere with the cell's ability to repair DNA damage from other sources.

Whole Body / GeneralNo Effects Found

Effects of mobile phone electromagnetic fields at nonthermal SAR values on melatonin and body weight of Djungarian hamsters (Phodopus sungorus).

Lerchl A et al. · 2008

German researchers exposed hamsters to cell phone radiation 24 hours a day for 60 days at levels matching the maximum allowed for humans. While melatonin levels (the sleep hormone) remained unchanged, hamsters exposed to certain frequencies gained up to 6% more body weight than unexposed animals, suggesting the radiation may affect metabolism even at supposedly safe levels.

Cellular EffectsNo Effects Found

Acute radio frequency irradiation does not affect cell cycle, cellular migration, and invasion.

Lee JJ et al. · 2008

Researchers exposed mouse cells to cell phone-level radiofrequency radiation (849 MHz) at power levels of 2 or 10 watts per kilogram for up to three days and measured whether this affected cell division, movement, or invasion capabilities. They found no statistically significant changes in any of these cellular functions compared to unexposed cells. This suggests that short-term RF exposure at these power levels does not disrupt basic cellular processes related to growth and migration.

Brain & Nervous SystemNo Effects Found

Local exposure of 849 MHz and 1763 MHz radiofrequency radiation to mouse heads does not induce cell death or cell proliferation in brain.

Kim TH et al. · 2008

Researchers exposed mice to cell phone radiation at 849 MHz and 1763 MHz frequencies for up to 12 months, using radiation levels about 4 times higher than current safety limits. They found no changes in brain cell death, cell growth, or tissue damage compared to unexposed mice. This suggests that chronic exposure to these specific frequencies at high levels may not cause detectable brain tissue changes in mice.

Brain & Nervous SystemNo Effects Found

Characterization of biological effect of 1763 MHz radiofrequency exposure on auditory hair cells.

Huang TQ et al. · 2008

Researchers exposed mouse auditory hair cells (the cells responsible for hearing) to cell phone radiation at 1763 MHz for up to 48 hours at extremely high power levels - 10 times stronger than typical phone use. They found no DNA damage, no changes in cell cycles, no stress responses, and only 29 out of 32,000 genes showed any change. The study suggests that even at these high exposure levels, cell phone radiation doesn't cause measurable biological damage to the specialized cells in our ears.

Immune SystemNo Effects Found

Molecular responses of Jurkat T-cells to 1763 MHz radiofrequency radiation.

Huang TQ, Lee MS, Oh E, Zhang BT, Seo JS, Park WY. · 2008

Researchers exposed immune system T-cells to cell phone radiation at 1763 MHz for 24 hours to see if it caused cellular damage or changes in gene activity. They found no significant effects on cell growth, DNA damage, or major gene expression changes, though two immune-related genes showed minor decreases. This suggests that 24-hour exposure to this specific frequency at high power levels did not cause detectable harm to these immune cells.

Cancer & TumorsNo Effects Found

Mobile phone base station radiation does not affect neoplastic transformation in BALB/3T3 cells.

Hirose H et al. · 2008

Researchers exposed mouse cells to radiofrequency radiation from mobile phone base stations for six weeks to see if it would cause cancerous changes. Even at high exposure levels (800 mW/kg), the radiation did not increase the rate of cell transformation into cancer cells. This suggests that base station radiation at these levels doesn't directly promote tumor formation in laboratory conditions.

Reproductive HealthNo Effects Found

HSP70 expression in human trophoblast cells exposed to different 1.8 Ghz mobile phone signals.

Franzellitti S, Valbonesi P, Contin A, Biondi C, Fabbri E. · 2008

Researchers exposed human placental cells to 1.8 GHz mobile phone radiation for up to 24 hours to study stress protein responses. While the cells showed no changes in stress proteins at the protein level, they found subtle changes in genetic activity (mRNA) that varied depending on the type of signal modulation used. This suggests that cellular responses to RF radiation may be more complex and nuanced than previously detected.

Cellular EffectsNo Effects Found

Whole-body exposure of radiation emitted from 900 MHz mobile phones does not seem to affect the levels of anti-apoptotic bcl-2 protein.

Yilmaz F, Dasdag S, Akdag MZ, Kilinc N · 2008

Turkish researchers exposed rats to radiation from 900 MHz cell phones for 20 minutes daily over one month to see if it affected bcl-2, a protein that helps prevent cell death in the brain and reproductive organs. They found no changes in bcl-2 levels in either brain or testicular tissue. This suggests that at least for this specific protein marker, short-term cell phone radiation exposure may not trigger cellular death pathways in these organs.

Brain & Nervous SystemNo Effects Found

Local exposure of 849 MHz and 1763 MHz radiofrequency radiation to mouse heads does not induce cell death or cell proliferation in brain

Kim TH et al. · 2008

Researchers exposed mice to cell phone radiation at 849 MHz and 1763 MHz frequencies for up to 12 months, delivering radiation directly to their heads at levels much higher than typical phone use. They found no evidence of brain cell death, abnormal cell growth, or other cellular changes in the exposed animals compared to unexposed controls.

A possible role for extra-cellular ATP in plant responses to high frequency, low amplitude electromagnetic field

Roux D et al. · 2008

French researchers exposed tomato plants to 900 MHz radiofrequency radiation (similar to cell phone frequencies) and found that it rapidly disrupted the plants' cellular energy systems. Within just 30 minutes, the plants' ATP levels (their main energy currency) dropped by 27%, and their overall energy status declined by 18%. This suggests that even low-level EMF exposure can interfere with fundamental cellular processes that keep living organisms functioning properly.

Microwave irradiation induces neurite outgrowth in PC12m3 cells via the p38 mitogen-activated protein kinase pathway.

Inoue S, Motoda H, Koike Y, Kawamura K, Hiragami F, Kano Y. · 2008

Researchers exposed rat nerve cells (PC12m3) to 2.45 GHz microwave radiation at 200 watts and found it triggered a 10-fold increase in nerve fiber growth compared to unexposed cells. The microwaves activated specific cellular pathways (p38 MAPK) that promote nerve development, and importantly, this effect occurred without causing cell death or damage. This suggests microwave radiation can directly influence nerve cell behavior through non-thermal biological mechanisms.

Is gene activity in plant cells affected by UMTS-irradiation? A whole genome approach.

Engelmann JC et al. · 2008

Researchers exposed plant cells to radio frequency radiation similar to what exists in urban environments with cell towers for 24 hours, then examined changes in gene activity across the entire plant genome. They found that 10 genes showed statistically significant changes in expression, though the changes were relatively small (less than 2.5-fold). The researchers concluded these minor genetic changes would likely have no meaningful impact on actual plant growth or reproduction.

Effects of electromagnetic radiation use on oxidant/antioxidant status and dna turn-over enzyme activities in erythrocytes and heart, kidney, liver, and ovary tissues from rats: possible protective role of Vitamin C.

Devrim E et al. · 2008

Researchers exposed female rats to 900 MHz electromagnetic radiation (the frequency used by cell phones) for 4 weeks and measured markers of cellular damage in their blood and organs. They found significant oxidative stress - essentially cellular damage from harmful molecules called free radicals - in the blood cells and kidneys of exposed rats. When some rats were given vitamin C along with the radiation exposure, it provided partial protection against this cellular damage.

Combinative exposure effect of radio frequency signals from CDMA mobile phones and aphidicolin on DNA integrity.

Tiwari R et al. · 2008

Researchers exposed blood samples from six healthy men to radio frequency signals from CDMA mobile phones for one hour, then tested for DNA damage using a technique called the comet assay. They found that while RF exposure alone didn't cause significant DNA damage, it did enhance DNA breaks when combined with a chemical that interferes with DNA repair. This suggests that mobile phone radiation may cause DNA damage that cells can normally repair, but problems could arise when repair mechanisms are compromised.

Further Reading

For a comprehensive exploration of EMF health effects and practical protection strategies, explore these books by R Blank and Dr. Martin Blank.