3,138 Studies Reviewed. 77.4% Found Biological Effects. The Evidence is Clear.
Research Guide

5G vs 4G Radiation: What's Different?

Based on 653 peer-reviewed studies

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People often ask whether 5G is more dangerous than 4G. This question requires understanding how 5G technology differs from previous generations and what research exists on each.

5G networks operate across multiple frequency bands. Low-band 5G (600-900 MHz) is actually similar to 4G frequencies. Mid-band 5G (2.5-4 GHz) overlaps with existing WiFi. High-band 5G (24-40+ GHz, "millimeter wave") represents the newest frequencies for consumer wireless exposure.

This page compares what research shows about radiation exposure from 5G versus 4G technologies.

Key Research Findings

  • 5G uses multiple frequency bands with different characteristics
  • Millimeter waves (high-band 5G) penetrate less deeply into tissue
  • More cell towers can actually reduce individual exposure levels

Related Studies (653)

Pulsed radiofrequency applied to dorsal root ganglia causes a selective increase in ATF3 in small neurons.

Hamann W, Abou-Sherif S, Thompson S, Hall S. · 2006

Researchers applied pulsed radiofrequency energy to nerve areas in rats and found it triggered a stress response in small pain-sensing neurons, even at temperatures below what would cause obvious tissue damage. The treatment specifically affected the types of nerve cells that carry pain signals (C and A-delta fibers), suggesting radiofrequency can alter nerve function through non-thermal mechanisms. This challenges the assumption that RF energy is only harmful when it heats tissue enough to cause visible damage.

Reproductive Health285 citations

Effects of electromagnetic radiation from a cellular phone on human sperm motility: an in vitro study.

Erogul O et al. · 2006

Researchers exposed sperm samples from 27 men to radiation from an active 900 MHz cell phone and compared them to unexposed samples. The cell phone radiation significantly reduced sperm movement, with fewer sperm swimming rapidly or slowly, and more sperm becoming completely immobile. This suggests that the electromagnetic fields from cell phones can directly impair male fertility by damaging sperm function.

A small temperature rise may contribute towards the apparent induction by microwaves of heat-shock gene expression in the nematode Caenorhabditis Elegans.

Dawe AS et al. · 2006

Researchers studied whether microwave radiation could trigger stress responses in tiny worms without actually heating them up. They discovered that what initially appeared to be a non-thermal biological effect was actually caused by tiny temperature increases (less than 0.2°C) in their experimental setup. When they improved their equipment to eliminate this slight heating, the biological effects disappeared entirely.

Evaluation of health risks caused by radio frequency accelerated carcinogenesis: the importance of processes driven by the calcium ion signal.

Anghileri LJ, Mayayo E, Domingo JL, Thouvenot P. · 2006

Researchers exposed mice to radio frequency radiation from cellular phones and found it accelerated cancer development in ways similar to known cancer-promoting chemicals. The study showed that RF exposure triggered calcium ion signals that activated cancer-causing genes while weakening immune defenses. This suggests cell phone radiation may speed up cancer progression through the same biological pathways used by established carcinogens.

Iron-radiofrequency synergism in lymphomagenesis.

Anghileri LJ, Mayayo E, Domingo JL. · 2006

Researchers investigated whether iron supplements might worsen cancer risk from radiofrequency radiation exposure using animals that naturally develop lymphomas (blood cancers) as they age. They found that combining radiofrequency exposure with iron injections created a synergistic effect, meaning the combination was more dangerous than either factor alone. This suggests that people receiving iron therapy might face increased cancer risk from RF radiation exposure.

.[Effect of 1.8 GHz radiofrequency electromagnetic fields on the expression of microtubule associated protein 2 in rat neurons]

Zhao R, Zhang SZ, Yao GD, Lu DQ, Jiang H, Xu ZP · 2006

Researchers exposed newborn rat brain cells to 1.8 GHz radiofrequency radiation (similar to cell phone frequencies) at 2 watts per kilogram for 24 hours and found that 34 out of 1,200 genes changed their expression levels. Most notably, a gene called MAP2, which helps maintain the structural framework of brain cells, became significantly more active after radiation exposure.

Effects of Global System for Mobile Communications 1800 MHz radiofrequency electromagnetic fields on gene and protein expression in MCF-7 cells.

Zeng Q, Chen G, Weng Y, Wang L, Chiang H, Lu D, Xu Z. · 2006

Researchers exposed human breast cancer cells (MCF-7) to cell phone radiation at 1800 MHz for 24 hours to see if it changed gene and protein activity. While initial tests suggested some genes might be affected, follow-up verification tests found no consistent changes. The study concluded that cell phone radiation at these levels does not produce convincing evidence of biological effects on cellular gene or protein expression.

[Effects of GSM 1800 MHz radiofrequency electromagnetic fields on protein expression profile of human breast cancer cell MCF-7.]

Zeng QL, Weng Y, Chen GD, Lu DQ, Chiang H, Xu ZP · 2006

Researchers exposed human breast cancer cells to cell phone radiation at levels similar to what phones produce, testing different exposure patterns and durations. They found that the radiation changed how cells produced proteins, particularly affecting proteins involved in DNA repair, cell communication, and basic cellular functions. The changes depended on both how long the cells were exposed and whether the exposure was continuous or intermittent.

HSP27 phosphorylation increases after 45 degrees C or 41 degrees C heat shocks but not after non-thermal TDMA or GSM exposures.

Vanderwaal RP, Cha B, Moros EG, Roti Roti JL. · 2006

Scientists tested whether cell phone radiation triggers the same cellular stress response as heat in laboratory cells. While heat clearly activated stress proteins, cell phone signals at levels 5-10 times higher than normal phone use caused no detectable stress response, suggesting different biological effects.

Protein Kinase C Activity in developing rat brain cells exposed to 2.45 GHz radiation

Paulraj R, Behari J · 2006

Researchers exposed developing rat brains to 2.45 GHz radiation (the same frequency as WiFi and microwaves) for 2 hours daily over 35 days. They found significant decreases in protein kinase C activity in the hippocampus, a brain region crucial for learning and memory, plus increased glial cells which can indicate brain inflammation. The study suggests that chronic microwave exposure during brain development may interfere with normal growth and cellular function.

Single strand DNA breaks in rat brain cells exposed to microwave radiation.

Paulraj R, Behari J · 2006

Researchers exposed developing rat brains to microwave radiation at frequencies commonly used in WiFi and radar systems (2.45 and 16.5 GHz) for 35 days. They found statistically significant DNA damage in brain cells, specifically single-strand breaks that can interfere with normal cellular function. This suggests that chronic exposure to low-level microwave radiation during brain development may cause genetic damage.

Modest increase in temperature affects ODC activity in L929 cells: low-level radiofrequency radiation does not.

Hoyto A, Sihvonen AP, Alhonen L, Juutilainen J, Naarala J · 2006

Researchers exposed mouse cells to cell phone-level radiofrequency radiation for 24 hours. The RF radiation itself caused no biological effects, but tiny temperature increases (less than 1°C) significantly affected cellular enzyme activity, showing temperature control is crucial in EMF studies.

Effects of GSM 1800 MHz radiofrequency electromagnetic fields on DNA damage in Chinese hamster lung cells.

Zhang DY, Xu ZP, Chiang H, Lu DQ, Zeng QL. · 2006

Chinese researchers exposed hamster lung cells to cell phone radiation at 1800 MHz (the frequency used by GSM networks) for either 1 or 24 hours to see if it would damage DNA. They found that 24-hour exposure at high intensity (3.0 W/kg) significantly increased DNA damage markers compared to unexposed cells, while 1-hour exposure showed no effect. This suggests that prolonged exposure to cell phone-type radiation may harm cellular DNA.

DNA damage and repair induced by acute exposure of microwave from mobile phone on cultured human lens epithelial cells

Sun LX, Yao K, Jiang H, He JL, Lu DQ, Wang KJ, Li HW · 2006

Researchers exposed human eye lens cells to cell phone radiation at different power levels for 2 hours to see if it damaged DNA. They found that lower exposure levels (similar to typical phone use) caused no DNA damage, but higher levels (4 times normal) did cause measurable DNA breaks and reduced cell growth. This suggests there may be a threshold below which cells can repair radiation damage effectively.

[Effect of acute exposure to microwave from mobile phone on DNA damage and repair of cultured human lens epithelial cells in vitro.]

Sun LX, Yao K, He JL, Lu DQ, Wang KJ, Li HW. · 2006

Researchers exposed human eye lens cells to cell phone radiation for 2 hours at different power levels to see if it damages DNA. They found that lower exposure levels (up to 3 W/kg) caused temporary DNA breaks that the cells could repair, but higher exposure (4 W/kg) caused permanent DNA damage that cells couldn't fix.

Immune System108 citations

Alteration in cellular functions in mouse macrophages after exposure to 50 Hz magnetic fields.

Frahm J, Lantow M, Lupke M, Weiss DG, Simkó M · 2006

Scientists exposed mouse immune cells to 50 Hz magnetic fields from power lines and found the cells became hyperactive. The fields increased the cells' ability to consume particles by 60% and boosted inflammatory chemicals 12-fold, suggesting everyday electrical frequencies can overstimulate immune responses.

Magnetic fields protect from apoptosis via redox alteration

De Nicola M et al. · 2006

Researchers exposed human immune cells to magnetic fields and found that even weak fields (0.09 mT and higher) disrupted the cells' internal chemical balance, increasing harmful molecules called reactive oxygen species while decreasing protective antioxidants. Surprisingly, this cellular stress actually made the cells more resistant to programmed cell death (apoptosis), suggesting magnetic fields might interfere with normal cellular cleanup processes that eliminate damaged cells.

Effect of acute exposure to microwave from mobile phone on DNA damage and repair of cultured human lens epithelial cells in vitro.

Sun LX, Yao K, He JL, Lu DQ, Wang KJ, Li HW. · 2006

Researchers exposed human eye lens cells to cell phone radiation for 2 hours at different power levels. Lower levels caused repairable DNA damage, but higher power (4 W/kg) caused permanent breaks cells couldn't fix, suggesting a threshold where radiation overwhelms natural repair.

Effects of GSM 1800 MHz radiofrequency electromagnetic fields on DNA damage in Chinese hamster lung cells

Zhang DY, Xu ZP, Chiang H, Lu DQ, Zeng QL. · 2006

Researchers exposed Chinese hamster lung cells to cell phone radiation (1800 MHz GSM) at levels similar to what your phone produces during heavy use. After 24 hours of intermittent exposure, they found a 35% increase in DNA damage markers compared to unexposed cells. This suggests that prolonged cell phone radiation exposure may cause genetic damage at the cellular level.

Effect of acute exposure to microwave from mobile phone on DNA damage and repair of cultured human lens epithelial cells in vitro

Sun LX, Yao K, He JL, Lu DQ, Wang KJ, Li HW. · 2006

Researchers exposed human eye lens cells to mobile phone radiation at different power levels for 2 hours. Lower exposures caused repairable DNA damage, but higher levels (4 W/kg) created permanent breaks cells couldn't fix, suggesting phone radiation may overwhelm the eye's natural repair systems.

Further Reading

For a comprehensive exploration of EMF health effects and practical protection strategies, explore these books by R Blank and Dr. Martin Blank.