3,138 Studies Reviewed. 77.4% Found Biological Effects. The Evidence is Clear.
Research Guide

5G vs 4G Radiation: What's Different?

Based on 653 peer-reviewed studies

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People often ask whether 5G is more dangerous than 4G. This question requires understanding how 5G technology differs from previous generations and what research exists on each.

5G networks operate across multiple frequency bands. Low-band 5G (600-900 MHz) is actually similar to 4G frequencies. Mid-band 5G (2.5-4 GHz) overlaps with existing WiFi. High-band 5G (24-40+ GHz, "millimeter wave") represents the newest frequencies for consumer wireless exposure.

This page compares what research shows about radiation exposure from 5G versus 4G technologies.

Key Research Findings

  • 5G uses multiple frequency bands with different characteristics
  • Millimeter waves (high-band 5G) penetrate less deeply into tissue
  • More cell towers can actually reduce individual exposure levels

Related Studies (653)

Cancer & TumorsNo Effects Found

Expression of the Proto-oncogene Fos after Exposure to Radiofrequency Radiation Relevant to Wireless Communications.

Whitehead TD et al. · 2005

Researchers exposed cells to radiofrequency radiation from cell phone signals (CDMA, FDMA, and TDMA) at high absorption rates of 5-10 W/kg to see if it would activate Fos, a gene linked to cellular stress and potential cancer development. They found no significant changes in Fos expression compared to unexposed cells, failing to confirm an earlier study that had reported such effects. This suggests that RF radiation at these levels may not trigger this particular cellular stress response.

Reproductive HealthNo Effects Found176 citations

Biological and morphological effects on the reproductive organ of rats after exposure to electromagnetic field.

Ozguner M et al. · 2005

Turkish researchers exposed male rats to 900 MHz radiofrequency radiation (similar to cell phones) for 30 minutes daily over 4 weeks and examined effects on reproductive organs. While the study found decreased testosterone levels and some structural changes in testicular tissue, the researchers concluded these changes did not significantly impact sperm production or overall reproductive function. The findings suggest cell phone-type radiation may cause hormonal changes but may not severely impair male fertility at these exposure levels.

Cellular EffectsNo Effects Found

Effects of exposure to a 1950 MHz radio frequency field on expression of Hsp70 and Hsp27 in human glioma cells.

Miyakoshi J et al. · 2005

Researchers exposed human brain tumor cells to 1950 MHz radiofrequency radiation (similar to 3G cell phone frequencies) at various intensities for up to 2 hours. While the radiation didn't affect cell growth or activate major stress response proteins, it did reduce a specific cellular protection mechanism at the highest exposure level (10 W/kg). This suggests that even when cells appear unaffected, subtle molecular changes may still be occurring.

Immune SystemNo Effects Found

Effect of 900 MHz electromagnetic fields on nonthermal induction of heat-shock proteins in human leukocytes.

Lim HB, Cook GG, Barker AT, Coulton LA. · 2005

Researchers exposed human white blood cells to 900 MHz cell phone radiation at various power levels for up to 4 hours to see if it triggered a cellular stress response. The cells showed no signs of producing stress proteins (the body's natural defense against harmful conditions) after RF exposure, even though they did respond normally when heated to 42°C. This suggests that cell phone-type radiation at these levels doesn't cause detectable cellular stress in immune cells.

Cellular EffectsNo Effects Found

Subchronic exposure of hsp70.1-deficient mice to radiofrequency radiation.

Lee JS, Huang TQ, Lee JJ, Pack JK, Jang JJ, Seo JS. · 2005

Researchers exposed genetically modified mice (lacking a key protective protein called HSP70) to cell phone radiation at 849 MHz and 1763 MHz frequencies for 10 weeks to see if repeated exposure would trigger cellular stress responses. Even though these mice were more vulnerable to stress than normal mice, the radiofrequency radiation at 0.4 W/kg caused no detectable changes in cell death, cell growth, or stress protein production. This suggests that moderate levels of RF radiation may not activate cellular stress pathways even in compromised organisms.

Cellular EffectsNo Effects Found

The Heat-Shock Factor is not Activated in Mammalian Cells Exposed to Cellular Phone Frequency Microwaves.

Laszlo et al. · 2005

Researchers tested whether cell phone radiation triggers the cellular stress response in mammalian cells by measuring heat-shock factor activation, a key protein that responds to cellular stress. They exposed hamster, mouse, and human cells to both low (0.6 W/kg) and high (5 W/kg) levels of cell phone frequency radiation but found no activation of this stress response pathway. This suggests that cell phone radiation at these levels does not trigger the specific cellular stress mechanism that some scientists theorized could contribute to cancer development.

Cancer & TumorsNo Effects Found

Effect of radiofrequency radiation exposure on mouse skin tumorigenesis initiated by 7,12-dimethybenz[alpha]anthracene.

Huang TQ, Lee JS, Kim TH, Pack JK, Jang JJ, Seo JS. · 2005

Researchers exposed mice to radiofrequency radiation at cell phone frequencies (849 MHz and 1,763 MHz) for 19 weeks to test whether RF exposure could promote skin tumor growth in animals already treated with a cancer-causing chemical. No skin tumors developed in any of the RF-exposed groups, while 95% of mice treated with a known tumor promoter developed tumors. This suggests that RF radiation at levels similar to mobile phones does not act as a tumor promoter for skin cancer.

Cellular EffectsNo Effects Found

An investigation of the effects of TETRA RF fields on intracellular calcium in neurones and cardiac myocytes.

Green AC et al. · 2005

Researchers exposed brain and heart cells to TETRA radio signals (the frequency used by emergency services) to see if it disrupted calcium levels inside the cells. Calcium is crucial for cell function, especially in neurons and heart muscle. The study found no significant changes in calcium activity at any exposure level tested, suggesting TETRA fields don't interfere with this fundamental cellular process.

DNA & Genetic DamageNo Effects Found

Effects of 1-week and 6-week exposure to GSM/DCS radiofrequency radiation on micronucleus formation in B6C3F1 Mice.

Gorlitz BD et al. · 2005

Researchers exposed mice to cell phone radiation (GSM and DCS frequencies) for 2 hours daily over 1 and 6 weeks to test whether it causes DNA damage in blood cells and other tissues. They found no increase in micronuclei (tiny fragments that indicate genetic damage) in any of the cell types examined, even at radiation levels up to 33.2 mW/g. This suggests that cell phone-type radiation at these exposure levels does not cause detectable genetic damage in mice.

Brain & Nervous SystemNo Effects Found

Effects of universal mobile telecommunications system (UMTS) electromagnetic fields on the blood-brain barrier In Vitro.

Franke H et al. · 2005

German researchers tested whether 3G cell phone signals could damage the blood-brain barrier (the protective filter that keeps toxins out of the brain) by exposing pig brain cells to UMTS signals for up to 84 hours. They found no evidence that the radiofrequency radiation affected the barrier's protective function, permeability, or structural proteins. This suggests that 3G signals at typical phone exposure levels may not compromise this critical brain protection system.

DNA & Genetic DamageNo Effects Found

Genotoxicity evaluation of electromagnetic fields generated by 835-MHz mobile phone frequency band.

Chang SK et al. · 2005

Researchers exposed bacterial cells to 835-MHz mobile phone radiation at high intensity (4 W/kg SAR) for 48 hours to test whether it causes DNA damage or genetic mutations. The study found no evidence that this radiofrequency radiation caused DNA breakdown or increased mutation rates in the bacterial test systems. This suggests that mobile phone frequencies may not directly damage genetic material under these laboratory conditions.

DNA & Genetic DamageNo Effects Found

Evaluation of genotoxic effects in human peripheral blood leukocytes following an acute in vitro exposure to 900 MHz radiofrequency fields.

Zeni O et al. · 2005

Italian researchers exposed human white blood cells to 900 MHz cell phone radiation for 2 hours at levels similar to what phones emit during calls. They tested multiple ways to detect DNA damage but found no statistically significant genetic harm at either exposure level tested. The study suggests that short-term exposure to cell phone radiation at typical use levels may not cause immediate DNA damage in blood cells.

2.45GHz radiofrequency fields alter gene expression in cultured human cells.

Lee S et al. · 2005

Researchers exposed human immune cells to 2.45 GHz radiofrequency radiation (the same frequency used in WiFi and microwave ovens) for 2-6 hours and found it altered the activity of hundreds of genes. After just 2 hours, 221 genes changed their expression patterns, increasing to 759 genes after 6 hours. Importantly, genes related to cell death increased their activity while genes controlling normal cell division decreased, and this happened without any heating effects.

Localized effects of microwave radiation on the intact eye lens in culture conditions.

Dovrat A et al. · 2005

Researchers exposed bovine eye lenses to low-power microwave radiation (1 GHz) for over 36 hours and found it significantly impacted the lens's optical function. While the lenses appeared to recover when radiation stopped, microscopic examination revealed permanent cellular damage that was completely different from heat-induced cataracts. This suggests microwave radiation can harm eye tissue through non-thermal mechanisms that may not be immediately visible.

Structural and kinetic effects of mobile phone microwaves on acetylcholinesterase activity.

Barteri M, Pala A, Rotella S. · 2005

Italian researchers exposed acetylcholinesterase, a crucial brain enzyme that helps nerve cells communicate, to radiation from a commercial cell phone. They found that the cell phone radiation irreversibly altered both the structure and activity of this enzyme. This matters because acetylcholinesterase is essential for proper nervous system function, and any disruption could potentially affect brain and nerve activity.

Radiofrequency-induced carcinogenesis: cellular calcium homeostasis changes as a triggering factor.

Anghileri LJ, Mayayo E, Domingo JL, Thouvenot P. · 2005

Researchers exposed cancer-prone mice to radiofrequency radiation for just one hour per week over four months and tracked their health for 18 months. The RF-exposed mice developed cancer earlier and died sooner than unexposed controls, with the radiation disrupting calcium transport in cells - a process critical for normal cell function. This suggests that even minimal RF exposure may accelerate cancer development in vulnerable populations.

Electromagnetic fields affect transcript levels of apoptosis-related genes in embryonic stem cell-derived neural progenitor cells.

Nikolova T et al. · 2005

German researchers exposed developing brain cells to both power line frequencies (50 Hz) and cell phone frequencies (1.71 GHz) for 6 hours to study genetic effects. They found that both types of electromagnetic fields triggered changes in genes that control cell death and DNA damage responses, though the cells themselves appeared to function normally afterward. This suggests that EMF exposure can activate cellular stress responses even when no obvious harm is visible.

Nitric oxide level in the nasal and sinus mucosa after exposure to electromagnetic field.

Yariktas M et al. · 2005

Researchers exposed rats to 900 MHz radiofrequency radiation (the same frequency used by many cell phones) for two weeks and measured nitric oxide levels in their nasal passages. They found that EMF exposure significantly increased nitric oxide production in the nose and sinus tissues, but giving the rats melatonin prevented this increase. This suggests that cell phone radiation may trigger inflammatory responses in nasal tissues.

Studying the synergistic damage effects induced by 1.8GHz radiofrequency field radiation (RFR) with four chemical mutagens on human lymphocyte DNA using comet assay in vitro.

Baohong Wang et al. · 2005

Researchers exposed human immune cells to 1.8 GHz cell phone radiation (the same frequency used by many mobile phones) for 2-3 hours to see if it damages DNA. While the radiation alone didn't harm DNA, it significantly amplified the damage when cells were also exposed to certain toxic chemicals. This suggests cell phone radiation may make our cells more vulnerable to other environmental toxins.

Impact of radio frequency electromagnetic radiation on DNA integrity in the male germline.

Aitken RJ, Bennetts LE, Sawyer D, Wiklendt AM, King BV. · 2005

Researchers exposed mice to cell phone-level radiation (900 MHz) for 12 hours daily over a week and examined sperm DNA for damage. While the mice appeared healthy and sperm counts looked normal, detailed genetic analysis revealed significant DNA damage in both the mitochondria (cellular powerhouses) and nuclear DNA of sperm cells. This suggests that radiofrequency radiation can harm genetic material in reproductive cells even when other measures appear normal.

Studying the synergistic damage effects induced by 1.8 GHz radiofrequency field radiation (RFR) with four chemical mutagens on human lymphocyte DNA using comet assay in vitro.

Baohong Wang et al. · 2005

Scientists tested whether cell phone radiation (1.8 GHz) makes DNA more vulnerable to damage from toxic chemicals. While radiation alone caused no harm, it significantly increased genetic damage when combined with two specific chemicals, suggesting phone exposure may amplify other environmental toxins' effects.

Non-thermal DNA breakage by mobile-phone radiation (1800MHz) in human fibroblasts and in transformed GFSH-R17 rat granulosa cells in vitro.

Diem E, Schwarz C, Adlkofer F, Jahn O, Rudiger H. · 2005

Researchers exposed human cells and rat cells to 1800 MHz mobile phone radiation at levels similar to what phones emit during calls. After 16 hours of exposure, both cell types showed DNA strand breaks (damage to genetic material). The damage occurred at non-thermal levels, meaning it wasn't caused by heating effects, and intermittent exposure patterns caused more damage than continuous exposure.

Further Reading

For a comprehensive exploration of EMF health effects and practical protection strategies, explore these books by R Blank and Dr. Martin Blank.