Medeiros LN, Sanchez TG. · 2016
Researchers performed a literature review using keywords including tinnitus, electromagnetic field, mobile phones, radio frequency, and electromagnetic hypersensitivity. They selected 165 articles considered clinically relevant to at least one of these subjects. The review notes that electromagnetic radiofrequency radiation can penetrate tissues and has proven thermogenic effects and potential biological and genotoxic effects. Some individuals are more sensitive to electromagnetic exposure, and there may be a common pathophysiology between this electrosensitivity and tinnitus. The authors state there are reasonable evidences to suggest caution for using mobile phones to prevent auditory damage and the onset or worsening of tinnitus.
Zhou Z, Shan J, Zu J, Chen Z, Ma W, Li L, Xu J. · 2016
At day 4 of incubation, 76 normally developing chick embryos were divided into a control group of 39 and a radiation group of 37, with the radiation group exposed to mobile phone radiation for 10 hours each day from day 4 to 19 of incubation. Behavioral tests were performed 4 days after hatching, followed by T2-weighted MR imaging and diffusion tensor imaging. Compared with controls, chicks in the radiation group showed significantly slower aggregation responses, lower belongingness, and weaker vocalization. No significant differences were found for brain size and structural maturity except for cerebellum size, which was significantly smaller in the radiation group. The hatching and heteroplasia rates did not differ significantly between groups.
Oster S et al. · 2016
Researchers developed and characterized a flexible experimental setup based on a transverse electromagnetic waveguide for controlled, reproducible exposure of developing neuronal networks in vitro. The Stripline showed very good performance in the 800-1000 MHz band, with simulations indicating uniform specific absorption rate values of 361.7 ± 11.4 mW/kg at 1 W, 900 MHz across a large exposure area. Thermal drift during exposure did not exceed 0.1 K in the cellular medium. Embryonic rat cortical neurons were cultured on microelectrode array chips for non-invasive electrophysiological assessment over several weeks, demonstrating the system's reliability for long-term studies.
López-Furelos A et al. · 2016
Forty rats were divided into four groups of ten. Twenty-four hours after exposure, HSP 90 and HSP 70 levels differed between cerebral hemispheres at high SAR, while caspase-3 did not. In cerebellar hemispheres, single RF exposure at high SAR altered HSP 90, HSP 70, and caspase-3 compared with controls. The combined signals did not produce additive effects on absorbed energy or biological outcomes.
Grell K et al. · 2016
Researchers used a point process model to investigate the association using tumor localization data from the INTERPHONE Study across Australia, Canada, Denmark, Finland, France, Germany, Israel, Italy, Japan, New Zealand, Norway, Sweden, and the United Kingdom. The association was statistically significant and independent of cumulative call time and cumulative number of calls. The main analysis included 792 regular mobile phone users diagnosed with a glioma between 2000 and 2004.
Ekici B, Tanındı A, Ekici G, Diker E. · 2016
The study included one hundred forty-eight healthy individuals who had used mobile phones for over 10 years and underwent 24-hour ambulatory ECG monitoring. Participants were divided into four groups based on daily mobile phone use: no use, less than 30 minutes, 30 to 60 minutes, and more than 60 minutes per day. The LF/HF ratio was higher and SDNN, SDANN, RMSSD, and pNN50 were lower in the mobile phone use groups compared to the control group, while heart rate, VLF, and total power did not differ significantly.
Chapman S, Azizi L, Luo Q, Sitas F. · 2016
Researchers examined age and gender specific brain cancer incidence rates for 19,858 males and 14,222 females diagnosed in Australia between 1982 and 2012 alongside mobile phone usage data from 1987 to 2012. Age-adjusted brain cancer incidence rates were stable in females and rose slightly in males over the 30-year period. Modelled expected rates assuming a causal relative risk of 1.5 with a 10-year lag were substantially higher than observed rates in 2012, with 1434 cases observed versus 1867 expected. Significant increases in incidence were seen only in people aged 70 years and older, and this increase began in 1982 before mobile phones were introduced.
Sun ZC et al. · 2016
Researchers exposed a mammalian central synapse to extremely low frequency electromagnetic fields for 8 to 10 days. The exposure increased calcium influx upon stimulation and facilitated all forms of vesicle endocytosis without changing the readily releasable pool size or exocytosis. The exposure also potentiated post-tetanic potentiation by increasing its peak amplitude without altering its time course. The mechanism involved enhanced expression of P/Q, N, and R type calcium channels at the presynaptic terminal.
Sales PM, de Andrade LM, Pitcher MR, Rola FH, Gondim FA. · 2016
Twenty-five male Wistar rats were divided into five subgroups of five animals each, receiving either no drug, Levodopa plus Benserazide for two or seven days, or Haloperidol for two days, and were exposed to sham then real cervicothoracic rEMS. In drug-free rats, rEMS reduced walking and increased cornering duration. Levodopa plus Benserazide pretreatment for two or seven days caused an additional decrease in walking after rEMS, with the greatest reduction after seven days, and it abolished climbing while increasing cornering.
Rostami A et al. · 2016
Researchers exposed male rats to 3 Hz and 60 Hz ELF/EMF using a protocol of two cycles of 2 hours per day for four days with a two-day interval. Immediately after exposure, locomotor activity was significantly lower in both exposed groups compared with sham-exposed rats. The exposure did not change anxiety-like behavior or short-term memory over the following two weeks. Electrophysiological recording showed a significant reduction in locus coeruleus firing rate after two hours of exposure. Proteomic analysis indicated global changes in the whole brain proteome after treatment.
Ambalayam S, Jain S, Mathur R. · 2016
Researchers divided 44 male Wistar rats into groups including sham, spinal cord injury, injury with magnetic field exposure, ventromedial hypothalamus lesion, lesion after injury, and lesion after injury with magnetic field exposure. Magnetic field exposure improved the study parameters, reduced c-Fos immunoreactivity in the ventromedial hypothalamus, reduced lesion volume, and increased myelination and neuronal regeneration at the injury site.
Kerimoğlu G et al. · 2016
Eighteen male Sprague Dawley rats aged 21 days were randomly assigned to control, sham, and EMF groups. The EMF group received a 900-MHz field for one hour each day throughout adolescence while the sham group was placed in the same cage without exposure. The EMF-exposed rats had fewer pyramidal neurons, more pyknotic neurons, higher malondialdehyde and glutathione levels, and lower catalase levels than the other groups.
Kerimoğlu G, Aslan A, Baş O, Çolakoğlu S, Odacı E. · 2016
Yang L, Chen Q, Lv B, Wu T · 2016
Researchers evaluated changes in EEG due to LTE EMF exposure. Exposure reduced spectral power and interhemispheric coherence in the alpha and beta bands of frontal and temporal brain regions. No significant change was observed in spectral power and interhemispheric coherence across different timeslots during and after exposure.
Shehu A, Mohammed A, Magaji RA, Muhammad MS · 2016
Twenty five male wistar rats were randomly divided into five groups of 5 animals each. The animals in groups II to V were exposed to a 10 min call consisting of 30 missed calls of 20 s each per day for 4 weeks. Open arm duration was significantly decreased in all experimental groups compared with the control. Catalase activity was significantly decreased in group IV and group V compared with the control.
Odacı E et al. · 2016
Purkinje cell numbers in the cerebellum of 32-day-old female offspring were significantly lower in the EMF group compared to both control and sham groups. Pathological changes including pyknotic neurons with dark cytoplasm were observed in the EMF group.
Mugunthan N et al. · 2016
Researchers exposed 36 mice to 2G mobile phone radiation for 48 minutes per day over 30 to 180 days. Neuron density was significantly lower in the CA1, CA2, and DGDB regions of exposed mice from the first to sixth month. Neuron density was significantly higher in the CA3 and DGVB regions of exposed mice. Nuclear diameter of neurons was lower in all studied hippocampal regions of exposed mice from the first to sixth month.
Kim JY, Kim HJ, Kim N, Kwon JH, Park MJ · 2016
The study examined how radiofrequency radiation affects glutamate-induced oxidative stress in mouse hippocampal HT22 cells. RF exposure alone marginally affected cell proliferation but significantly increased glutamate-induced cytotoxicity. Glutamate raised ROS levels and RF exposure further increased ROS production. NAC treatment completely abrogated glutamate- and RF-induced ROS production and cell death, restoring cell proliferation. Treatment with a JNK inhibitor restored cell proliferation.
İkinci A et al. · 2016
The study began with 24 Sprague-Dawley male rats aged 3 weeks, divided equally into control, sham, and EMF exposure groups. EMF group rats were exposed to 900 MHz EMF for 1 hour daily from postnatal day 21 to 46. Biochemistry showed significantly increased malondialdehyde and glutathione in the EMF group versus control and sham, while catalase and superoxide dismutase were higher in both sham and EMF groups versus control. Light microscopy revealed spinal cord atrophy, vacuolization, myelin thickening, and perikarya irregularities in the EMF group. Transmission electron microscopy showed loss of myelin sheath integrity, invagination into the axon, and broad vacuoles in axoplasm.
Çeliker M et al. · 2016
Fourteen adult Wistar albino rats were randomly divided into two groups of seven, with the study group exposed continuously for 30 days to a 2100 MHz GSM-like electromagnetic field at 5.4 dBm (3.47 mW) to simulate mobile phone talk mode. Auditory brainstem responses recorded after 30 days did not differ significantly between exposed and control rats. Histopathologic analysis showed increased degeneration signs in the exposed group (p = 0.007), and immunohistochemical analysis revealed an increased apoptotic index (p = 0.002).
He GL et al. · 2016
Choi Y-J, Choi Y-S · 2016
Male mice were exposed for 9 weeks and female mice for 11 weeks to smartphone electromagnetic radiation. Spatial working memory was tested with a Y maze and hippocampal progenitor cell proliferation was measured using BrdU labeling. After 9 weeks there was no significant difference in spontaneous alternation scores or hippocampal progenitor cell proliferation between exposed and control mice.
Valbonesi P, Franzellitti S, Bersani F, Contin A, Fabbri E. · 2016
Researchers exposed rat PC12 cells to a 1.8 GHz 217-GSM signal at 2 W/kg SAR for 24 hours. AChE enzyme activity was measured by Ellman's method, mRNA by real-time PCR, and protein by Western blotting. AChE enzymatic activity increased 1.4-fold in exposed cells, while mRNA and protein expression were not affected. The authors report this as the first evidence of RF-EMF effects on AChE activity in mammalian cells at this SAR.
Stasinopoulou M et al. · 2016
Bouji M, Lecomte A, Gamez C, Blazy K, Villégier AS. · 2016
Researchers exposed aged (22–24 months) and young (4–6 months) adult male rats to head RF-EMF exposures at 900 MHz, with a specific absorption rate of 6 W/kg, for 45 minutes per day for 1 month. Aged rats showed deficits in spatial learning, exploration, anxiety-related behaviors, and increased hippocampal ILs and cortical IL-1β. The senescence-typical neurobiological deficits were not modified by RF-EMF exposures, and the study did not support the hypothesis of a specific cerebral vulnerability to RF-EMF during senescence. RF-EMF-exposed rats, with young and aged adults pooled, had decreased anxiety-related behaviors in the elevated plus maze.
