3,138 Studies Reviewed. 77.4% Found Biological Effects. The Evidence is Clear.
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Immune System

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Key Finding: 77% of 274 studies on immune system found biological effects from EMF exposure.

Of 274 studies examining immune system, 77% found measurable biological effects from EMF exposure.

Lowest Documented Effect

Research found effects on immune system at exposures as low as:

Study Exposure Level in ContextA logarithmic scale showing exposure levels relative to Building Biology concern thresholds and regulatory limits.Study Exposure Level in Context0.00000052, 0.00001536, 0.00021268Extreme Concern1,000 uW/m2FCC Limit10M uW/m2Effects observed in the No Concern range (Building Biology)FCC limit is 19,230,769,230,769x higher than this exposure level

Research Overview

  • -When 106 out of 129 studies (82.2%) document immune system effects from electromagnetic field exposure, we're looking at one of the most consistently demonstrated biological impacts of EMF.
  • -The science demonstrates that your body's natural defense system responds to wireless radiation in ways that can compromise your ability to fight infections, heal from injuries, and maintain optimal health.
  • -Research has documented a range of immune system disruptions, from reduced white blood cell counts and altered antibody production to increased inflammatory markers and compromised cellular repair mechanisms.

When 106 out of 129 studies (82.2%) document immune system effects from electromagnetic field exposure, we're looking at one of the most consistently demonstrated biological impacts of EMF. The science demonstrates that your body's natural defense system responds to wireless radiation in ways that can compromise your ability to fight infections, heal from injuries, and maintain optimal health.

While we don't yet have as many studies specifically examining EMF effects on immune function as we do for other biological systems, the evidence that does exist points to concerning patterns.

Importantly, many effects occur at exposure levels below those causing significant body temperature increases, with some studies showing responses at specific absorption rates as low as 0.14 W/kg.

Source: BioInitiative Working Group. BioInitiative Report: A Rationale for Biologically-based Public Exposure Standards for Electromagnetic Radiation. Edited by Cindy Sage and David O. Carpenter, BioInitiative, 2012, updated 2020. www.bioinitiative.org

Showing 274 studies

Toxicologic study of electromagnetic radiation emitted by television and video display screens and cellular telephones on chickens and mice.

Bastide M, Youbibier-Simoa BJ, Lebecq JC, Giaimis J. · 2001

French researchers exposed developing chick embryos and young chickens to electromagnetic radiation from computer monitors and cell phones to study health effects. They found dramatically increased embryo death rates (47-68%) and severely reduced levels of important hormones including stress hormones, immune antibodies, and melatonin. Even when they used copper shielding to reduce the radiation intensity, the harmful effects persisted.

Multinucleated giant cell appearance after whole body microwave irradiation of rats.

Trosic I. · 2001

Researchers exposed rats to microwave radiation at 2450 MHz (the same frequency used in microwave ovens and some WiFi devices) and examined lung cells. They found that exposure caused immune cells in the lungs to fuse together into abnormal giant cells with multiple nuclei - a sign of chronic lung inflammation. The effect became stronger with more radiation treatments, suggesting cumulative damage to the respiratory system.

Effect of centimeter microwaves and the combined magnetic field on the tumor necrosis factor production in cells of mice with experimental tumors

Novoselova EG, Ogai VB, Sorokina OV, Novikov VV, Fesenko EE · 2001

Researchers exposed tumor-bearing mice to extremely low-level microwaves (1 microW/cm2) combined with weak magnetic fields for 1.5 hours daily over 7 days. They found that this dual exposure increased production of tumor necrosis factor, a protein that helps the immune system fight cancer cells. The results suggest that certain EMF exposures might actually enhance the body's natural tumor-fighting response.

[Effect of extremely high frequency electromagnetic radiation of low intensity on parameters of humoral immunity in healthy mice.]

Lushnikov KV, Gapeev AB, Sadovnikov VB, Cheremis NK. · 2001

Russian researchers exposed mice to 42 GHz radiation (millimeter waves like those in 5G) at low power levels. After 20 days of daily exposure, immune organs shrank significantly - the thymus by 17.5% and spleen by 14.5%, suggesting prolonged millimeter wave exposure may weaken immune system function.

Stimulation of phagocytosis and free radical production in murine macrophages by 50 Hz electromagnetic fields.

Simkó M, Droste S, Kriehuber R, Weiss DG · 2001

Researchers exposed immune cells called macrophages from mouse bone marrow to 50 Hz magnetic fields (the same frequency as power lines) for 45 minutes. They found that these fields significantly increased the cells' ability to engulf foreign particles by 36% and boosted production of free radicals. This suggests that even short exposures to power frequency magnetic fields can activate immune system responses at the cellular level.

Evidence of Oxidative Stress in American Kestrels Exposed to Electromagnetic Fields

Fernie KJ, Bird DM. · 2001

Researchers exposed American kestrels (small falcons) to electromagnetic fields similar to those from power lines for nearly 24 hours daily over 91 days. The EMF-exposed birds showed signs of immune system stress and oxidative damage, including reduced blood proteins, lower red blood cell counts, and decreased protective antioxidants. This suggests that even relatively low-level EMF exposure can trigger biological stress responses in wildlife.

Multinucleated giant cell appearance after whole body microwave irradiation of rats.

Trosic I · 2001

Researchers exposed rats to microwave radiation at 2450 MHz (the same frequency used in microwave ovens and WiFi) for 2 hours daily over 30 days and examined lung cells. They found that the radiation caused lung immune cells called macrophages to develop abnormal multiple nuclei, with the effect becoming more severe with longer exposure. This cellular abnormality indicates the lungs were under stress from the microwave exposure.

Cancer & TumorsNo Effects Found117 citations

Radiofrequency exposure and mortality from cancer of the brain and lymphatic/hematopoietic systems.

Morgan RW et al. · 2000

Researchers followed nearly 200,000 Motorola employees for 20 years to see if workplace radiofrequency exposure increased their risk of brain cancer, lymphoma, or leukemia. Workers exposed to RF radiation actually had lower rates of these cancers compared to the general population, with no increase in cancer risk even among those with the highest exposures or longest work duration.

DNA & Genetic DamageNo Effects Found

Cytogenetic investigations on microwavesemitted by a 455.7 MHz car phone

Maes A, Collier M, Verschaeve L · 2000

Belgian researchers exposed human immune cells (lymphocytes) to radiation from a 455.7 MHz car phone at high intensity levels (6.5 W/kg SAR) to see if it would cause genetic damage or make the cells more vulnerable to other cancer-causing agents. They found no evidence that the phone radiation caused chromosome damage on its own, nor did it increase the harmful effects when combined with known mutagens like chemicals or X-rays.

DNA & Genetic DamageNo Effects Found

Primary DNA Damage in Human Blood Lymphocytes Exposed In Vitro to 2450 MHz Radiofrequency Radiation.

Vijayalaxmi, Leal BZ, Szilagyi M, Prihoda TJ, Meltz ML · 2000

Researchers exposed human blood cells to microwave radiation at 2450 MHz (the same frequency used in microwave ovens and some WiFi devices) for 2 hours to see if it would damage DNA. They found no evidence of DNA breaks or damage in the cells, even when they checked again 4 hours later to see if the cells could repair any potential damage. This suggests that this specific type and level of radiofrequency exposure may not cause immediate DNA harm.

Immune SystemNo Effects Found

Enhancement of nitric oxide generation by low frequency electromagnetic field.

Yoshikawa T et al. · 2000

Researchers exposed mice to 60 Hz magnetic fields (the same frequency as power lines) at 0.1 mT to see how it affected nitric oxide production in the liver. They found that magnetic field exposure alone didn't generate nitric oxide, but when combined with an immune system trigger, it significantly enhanced nitric oxide production compared to the trigger alone. This suggests that power frequency magnetic fields may amplify certain biological responses even when they don't cause direct effects.

[Modeling of the effect of modulated electromagnetic radiation on animal cells].

Gapeev AB, Chemeris NK · 2000

Russian researchers created a mathematical model to understand how electromagnetic radiation affects calcium levels inside immune cells called neutrophils. They found that when the radiation frequency matched the cell's natural calcium signaling rhythm (around 1 Hz), it could increase calcium levels by more than 50%. This suggests that EMF exposure might disrupt normal cell function by interfering with the calcium signals that cells use to communicate and respond to their environment.

Combined effects of traffic and electromagnetic fields on the immune system of fertile atopic women.

Del Signore A, Boscolo P, Kouri S, Di Martino G, Giuliano G · 2000

Researchers studied how electromagnetic fields affect the immune systems of women with allergies compared to those without, all living in areas with traffic pollution. They found that women with allergies who were also exposed to electromagnetic fields had weakened immune responses, including reduced natural killer cell activity and higher allergy markers. This suggests that people with existing allergies may be more vulnerable to electromagnetic field exposure.

Induction of micronuclei in human lymphocytes exposed in vitro to microwave radiation.

Zotti-Martelli L, Peccatori M, Scarpato R, Migliore L, · 2000

Italian researchers exposed human immune cells (lymphocytes) to microwave radiation at frequencies of 2.45 and 7.7 GHz to see if it would damage their DNA. They found that high-power exposures (30 mW/cm²) for 30 and 60 minutes caused significant genetic damage, creating abnormal cell structures called micronuclei that indicate DNA breaks. This matters because it demonstrates that microwave radiation can directly damage human genetic material under laboratory conditions.

Non-thermal effects of continuous 2.45 GHz microwaves on Fas-induced apoptosis in human Jurkat T-cell line.

Peinnequin A et al. · 2000

French researchers exposed human immune cells (T-cells) to 2.45 GHz microwave radiation for 48 hours at power levels well below heating thresholds. They found that this non-thermal microwave exposure interfered with a specific cellular death pathway called Fas-induced apoptosis, suggesting the radiation disrupted normal immune cell function at the molecular level.

Effects on protein kinase C and gene expression in a human mast cell line, HMC-1, following microwave exposure.

Harvey C, French PW. · 2000

Researchers exposed human immune cells (mast cells) to microwave radiation at 864.3 MHz for 20 minutes daily over a week, using power levels that kept the cells cooler than body temperature. They found that this non-thermal exposure altered the activity of protein kinase C (a key cellular signaling molecule) and changed the expression of three genes, including one linked to cancer development and another associated with cell death.

Immune SystemNo Effects Found

Occupational exposure to high frequency electromagnetic fields and its effect on human immune parameters.

Tuschl et al. · 1999

Researchers measured high-frequency electromagnetic field exposure among physiotherapists operating medical diathermy devices and found exposure levels that considerably exceeded recommended limits. Despite this chronic occupational exposure, blood tests revealed no statistically significant differences in immune system function between exposed workers and unexposed controls. All immune parameters remained within normal ranges for both groups.

Immune SystemNo Effects Found

[Stimulation of murine natural killer cells by weak electromagnetic waves in the centimeter range].

Fesenko EE et al. · 1999

Russian researchers exposed mice to weak microwave radiation (8.15-18 GHz) for 24-72 hours and found their natural killer cells - immune cells that fight cancer and infections - became 130-150% more active. The immune boost lasted at least 24 hours after exposure ended, but shorter exposures of just a few hours showed no effect.

Immune SystemNo Effects Found

In vivo exposure of rats to GSM-modulated microwaves: flow cytometry analysis of lymphocyte subpopulations and of mitogen stimulation.

Chagnaud JL, Veyret B · 1999

French researchers exposed rats to GSM cell phone radiation and examined their immune system cells using advanced laboratory techniques. They found no changes in the rats' lymphocytes (white blood cells that fight infection) or in how well these cells responded to immune challenges. The study suggests that low-level pulsed microwaves from cell phones may not harm basic immune system function.

The effect of various occupational exposures to microwave radiation on the concentrations of immunoglobulins and T lymphocyte subsets

Moszczynski P et al. · 1999

Researchers examined immune system changes in workers exposed to microwave radiation from TV transmission centers, satellite communications, and radar operations. They found that different types of microwave exposure caused distinct changes in immune proteins (immunoglobulins) and specific white blood cells (T8 lymphocytes), though workers didn't show obvious symptoms. The study demonstrates that occupational microwave exposure can alter immune function in measurable ways.

Learn More

For a comprehensive exploration of EMF health effects including immune system, along with practical protection strategies, explore these books by R Blank and Dr. Martin Blank.

FAQs: EMF & Immune System

When 106 out of 129 studies (82.2%) document immune system effects from electromagnetic field exposure, we're looking at one of the most consistently demonstrated biological impacts of EMF. The science demonstrates that your body's natural defense system responds to wireless radiation in ways that can compromise your ability to fight infections, heal from injuries, and maintain optimal health.
The BioInitiative Report database includes 274 peer-reviewed studies examining the relationship between electromagnetic field exposure and immune system. These studies have been conducted by researchers worldwide and published in scientific journals. The research spans multiple decades and includes various types of EMF sources including cell phones, WiFi, power lines, and other common sources of electromagnetic radiation.
77% of the 274 studies examining immune system found measurable biological effects from EMF exposure. This means that 210 studies documented observable changes in biological systems when exposed to electromagnetic fields. The remaining 23% either found no significant effects or had inconclusive results, which is typical in scientific research where study design and exposure parameters vary.