Pettersson D et al. · 2014
Researchers conducted a population-based, nation-wide, case-control study of acoustic neuroma in Sweden. Eligible cases were persons aged 20 to 69 years diagnosed between 2002 and 2007, and controls were randomly selected from the population registry matched on age, sex, and residential area. Ever regular mobile phone use was associated with an odds ratio of 1.18 (95% CI 0.88 to 1.59).
Hsu MH et al. · 2014
Researchers conducted a population-based study using cancer registry data from 2000 to 2009 and cell phone user statistics from the National Communication Commission. The National Cancer Registry recorded 4 incidences and 4 deaths due to malignant neoplasms in Taiwan during 2000-2009. Ten years of observational data showed no significant effect of intensive cell phone use on the incidence rate or mortality of malignant brain tumors in Taiwan. The authors concluded they detected no correlation between cell phone use and malignant brain tumor morbidity or mortality in Taiwan.
Hauri DD et al. · 2014
Researchers conducted a time-to-event analysis of children under 16 living in Switzerland on December 5, 2000, with follow-up until December 31, 2008. They also included an incidence density cohort of all children living in Switzerland for some time between 1985 and 2008. In the time-to-event analysis of 997 cancer cases, the adjusted hazard ratio for the highest exposure category was 1.03 for all cancers, 0.55 for childhood leukemia, and 1.68 for childhood CNS tumors. The incidence density analysis of 4,246 cancer cases showed similar results for all cancers and leukemia but did not indicate a CNS tumor risk, with an incidence rate ratio of 1.03.
Shirai T et al. · 2014
Researchers exposed rats to 2.14 GHz W-CDMA signals for 20 hours a day over three generations. No abnormalities were observed in mother rats or offspring across any biological parameters including neurobehavioral function. The study used three SAR levels: high (<0.24 W/kg), low (<0.08 W/kg), and sham exposure. Pregnant rats were exposed from gestational day 7 to weaning, and offspring were continuously exposed until 6 weeks of age.
Kim HS et al. · 2014
Researchers assigned male Sprague-Dawley rats to cage-control, sham-exposed, and CDMA-exposed groups, with six rats per group. The CDMA-exposed rats received whole-body exposure to an 848.5 MHz CDMA signal at 2 W/kg for either 1 or 8 hours daily, five days a week, for two weeks. During the last five exposure days, all rats were injected with BrdU to label dividing cells, and the numbers of BrdU-positive cells in the subventricular zone and dentate gyrus were estimated using an unbiased stereological method. The study found no significant difference in BrdU-positive cell counts in either brain region between CDMA-exposed rats and both control groups.
Szyjkowska A, Gadzicka E, Szymczak W, Bortkiewicz A. · 2014
Most respondents used their phones daily or almost daily. Users who talked frequently and for long periods reported headaches (63.2%) and fatigue (45%) significantly more often than other users. Intensive users also reported warmth around the ear (47.3%) and at the auricle (44.6%) more frequently. Most symptoms appeared during or right after a call and disappeared within 2 hours, though 26% reported continuous headache lasting over 6 hours.
Vijayalaxmi, Prihoda TJ. · 2014
The study aimed to investigate whether mobile phone radiofrequency fields and brain cancer show an adaptive response. The authors re-examined all odds ratios from the INTERPHONE study published in 2011. Their analysis showed 24.3% decreased and 0.7% increased risk for meningioma and 22.1% decreased and 6.6% increased risk for glioma. They hypothesized that the overwhelming evidence for decreased risk may be due to induction of an adaptive response.
Trunk A et al. · 2014
Researchers recorded EEG and event-related potentials in an oddball paradigm during four sessions combining caffeine and UMTS mobile phone exposure. Caffeine significantly shortened reaction time and decreased the P300 area under the curve compared to control or mobile phone exposure alone. No effects on reaction time or P300 were observed for UMTS mobile phone exposure alone or combined with caffeine. The authors concluded no interactive or synergistic effects of caffeine and UMTS mobile phone exposure on neural or cognitive measures.
Hardell L, Carlberg M, · 2014
In total, 1498 cases (89% participation) and 3530 controls (87% participation) were included. Mobile phone use increased glioma risk with an overall odds ratio of 1.3 (95% CI 1.1–1.6), rising to 3.0 (95% CI 1.7–5.2) for latency over 25 years. Cordless phone use increased glioma risk with an overall odds ratio of 1.4 (95% CI 1.1–1.7), with highest risk in the >15–20 years latency group (OR 1.7, 95% CI 1.1–2.5). Ipsilateral mobile phone use had an odds ratio of 1.8 (95% CI 1.4–2.2) and ipsilateral cordless phone use had an odds ratio of 1.7 (95% CI 1.3–2.1). The highest risk was for glioma in the temporal lobe, and first use before age 20 gave higher odds ratios than later first use.
Chiu CT, Chang YH, Chen CC, Ko MC, Li CY. · 2014
Carlberg M, Hardell L. · 2014
Researchers analyzed survival of 1678 glioma patients from the 1997-2003 and 2007-2009 case-control studies. Wireless phone use with more than 20 years latency showed an increased hazard ratio of 1.7 for glioma overall. For glioblastoma multiforme, mobile phone use had a hazard ratio of 2.0 and cordless phone use a hazard ratio of 3.4 in the same latency category.
Akhavan-Sigari R, Baf MM, Ariabod V, Rohde V, Rahighi S. · 2014
Researchers studied sixty-three glioblastoma patients who underwent tumor resection between 2008 and 2011. They measured p53 gene expression in central and peripheral tumor zones using RT-PCR. Among patients using cell phones three or more hours daily, 65% showed higher mutant p53 expression in the peripheral zone, a statistically significant increase. This increased mutant p53 expression was significantly correlated with shorter overall survival. The risk was not higher for ipsilateral exposure.
Adibzadeh F et al. · 2014
Researchers performed detailed dosimetric simulations for 20 head models to quantify how head morphology affects RF dose in different brain regions. The variation in averaged SAR among heads reached up to 16.4 dB in a 1 cm³ brain cube using the field-sensor method and up to 15.8 dB in the medulla using the Talairach method. Head models were exposed to generic mobile phone fields at 835 and 1900 MHz in tilted and cheek positions. The authors concluded that head morphology is an important uncertainty source and that dosimetric analyses for specific brain regions should use real morphology.
Adachi-Mejia AM et al. · 2014
The study aimed to determine if mobile phones interfere with adolescent sleep, and researchers conducted a pilot test in a pediatric primary care practice with 454 patients aged 12 to 20 years, half female, attending a well-child visit. Adolescents completed paper-and-pencil surveys in the waiting room. More than half took their mobile phone to bed (62.9%) and kept it turned on while sleeping (56.8%). More than one-third texted after going to bed (36.7%), and 7.9% were awakened by a text two or more times per week. Almost half used their phone as their alarm (45.7%).
Zheng F et al. · 2014
A total of 7720 middle school students were involved in this cross-sectional study and 7102 valid questionnaires were obtained. Inattention was assessed using DSM-IV-TR criteria for the attention deficit component of ADHD. After adjusting for confounders, inattention was significantly associated with MP ownership, entertainment time on MP per day, MP position during the day, and MP mode at night. The strongest association was among students who spent more than 60 minutes per day playing on their MP.
Yogesh S, Abha S, Priyanka S. · 2014
The study enrolled 100 medical students divided into cases with more than two hours of daily mobile phone use (n=57) and controls with two hours or less (n=43), and assessed sleep quality using the Pittsburg Sleep Quality Index. Differences between groups were tested with the Mann-Whitney U test and Student's t-test, and correlations were analyzed using Spearman's rank correlation with significance set at p<0.05. Evening mobile phone use showed a significant negative association with sleep quality (r=-0.606, p=0.042), where higher PSQI scores indicate worse sleep.
Velayutham P, Govindasamy GK, Raman R, Prepageran N, Ng KH · 2014
The study was a prospective single-blinded study that used high-frequency audiometry. Researchers compared the dominant ear to the non-dominant ear in 100 subjects because they could not find enough non-users as a control group. Chronic mobile phone usage revealed high frequency hearing loss in the dominant ear compared to the non-dominant ear. The loss in the dominant ear was statistically significant (P < 0.05).
Saikhedkar N et al. · 2014
Researchers exposed 30-day-old rats to 900 MHz radio waves from a mobile handset for 4 hours per day over 15 days. Exposed rats showed more anxiety and poor learning compared to control and sham groups. Antioxidant enzymes and non-enzymatic antioxidants changed significantly and lipid peroxidation increased in exposed rats.
Movvahedi MM et al. · 2014
Researchers enrolled 60 elementary school children aged 8 to 10 years in Shiraz, Iran. They used standardized computer-based tests of visual reaction time and short-term memory modified for children. Each test was repeated ten times in both real and sham exposure phases with a 30 min interval between phases. After a 10 min talk period, mean short-term memory scores were higher than after sham exposure (P = 0.030). Mean reaction times did not differ significantly between talk and sham exposure (P = 0.629).
Kesari KK, Meena R, Nirala J, Kumar J, Verma HN. · 2014
Researchers exposed 45-day-old male Wistar rats to 3G cell phone radiation for 2 hours a day over 60 days using a computer-controlled stepper motor. Exposure significantly induced DNA strand breaks and increased micronuclei, caspase 3, and apoptosis in the brain. Western blotting showed a transient increase in phosphorylation of hsp27, hsp70, and p38MAPK, leading to mitochondrial dysfunction and caspase activation. The researchers concluded that oxidative stress activates the hsp27/p38MAPK pathway and that 3G radiation affects brain function and causes neurological disorders.
Choi SB, Kwon MK, Chung JW, Park JS, Chung K, Kim DW. · 2014
Two volunteer groups of 26 adults and 26 teenagers were simultaneously investigated by measuring physiological changes in heart rate, respiration rate, and heart rate variability for autonomic nervous system (ANS), eight subjective symptoms, and perception of RF-EMFs during sham and real exposure sessions. Short-term WCDMA RF-EMFs generated no significant changes in ANS, subjective symptoms, or the percentages of those who believed they were being exposed in either group.
Yilmaz A et al. · 2014
Researchers exposed rats to electromagnetic waves from mobile phones at frequencies between 1900 and 2100 MHz for a four-week period to study effects on apoptosis-related proteins in brain tissue. Immunohistopathological examinations showed that the study group had more p53 and Bcl-2 positive stained cells, and they were stained denser, with statistically significant differences between the study and control groups (p < 0.003). The researchers concluded that electromagnetic waves from mobile phones may have an effect on apoptosis.
Razavinasab M, Moazzami K, Shabani M · 2014
Researchers exposed pregnant Wistar rats to 900 MHz pulsed-EMF irradiation for 6 hours per day during gestation, then tested the offspring using behavioral, histological, and electrophysiological methods. Mobile phone exposure was associated with a decrease in the number of action potentials fired and an increase in the amplitude of afterhyperpolarization in exposed offspring compared with controls. Phone exposure significantly altered learning acquisition and memory retention in both male and female offspring rats compared with control rats. Light microscopy of brain sections showed normal morphology in both control and mobile phone-exposed rats.
Pelletier A et al. · 2014
Researchers recorded thermal preference and sleep in 18 young male Wistar rats, with nine exposed to a low-intensity RF-EMF at 900 MHz and nine serving as non-exposed controls. During the light period, exposed rats preferred to sleep at an air temperature of 31°C while controls preferred 28°C. During the dark period, no significant differences between groups were found.
Narayanan SN, Kumar RS, Kedage V, Nalini K, Nayak S, Bhat PG · 2014
Researchers studied the effects of 900 MHz radio-frequency electromagnetic radiation on oxidant stress and antioxidant defense in discrete brain regions of adolescent rats. Thirty-six male Wistar rats aged 6 to 8 weeks were divided into a control group, a sham group, and an RF-EMR-exposed group, with 12 animals in each group. The exposed group received 900 MHz RF-EMR at a peak power density of 146.60 µW/cm2 for one hour per day for four weeks from an activated GSM mobile phone. Elevated TBARS levels were found in all brain regions studied, and altered behavioral performances were found in RF-EMR-exposed rats.
