6,486 Studies Reviewed. 85.2% of Original Studies Found Biological Effects. The Evidence is Clear.
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Brain & Nervous System

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Key Finding: 83% of 1,950 primary studies on brain & nervous system found biological effects from EMF exposure.

Of 1,950 studies examining brain & nervous system, 83% found measurable biological effects from EMF exposure.

Lowest Documented Effect

Research found effects on brain & nervous system at exposures as low as:

Study Exposure Level in ContextStudy Exposure Level in Context4.3 × 10⁻⁵ mGExtreme Concern - 5 mGFCC Limit - 2,000 mGEffects documented below the Building Biology "No Concern" threshold (0.2 mG)FCC limit is 46.5 million times higher than this level

Research Overview

  • -When you review the peer-reviewed literature on electromagnetic field exposure and brain function, the numbers tell a compelling story: 84% of the 2,753 studies examining this relationship have documented measurable effects.
  • -This isn't a fringe concern or preliminary finding.
  • -This is the dominant scientific picture, and it deserves your attention.

When you review the peer-reviewed literature on electromagnetic field exposure and brain function, the numbers tell a compelling story: 84% of the 2,753 studies examining this relationship have documented measurable effects. This isn't a fringe concern or preliminary finding. This is the dominant scientific picture, and it deserves your attention. The documented effects span multiple systems within your nervous system.

Of 2,753 studies examining EMF effects on the brain and nervous system, approximately 84 percent found measurable biological effects.

The scientific evidence demonstrates that radiofrequency electromagnetic fields from mobile phones and wireless devices produce measurable effects on nervous system function and cellular processes in the brain.

Source: BioInitiative Working Group. BioInitiative Report: A Rationale for Biologically-based Public Exposure Standards for Electromagnetic Radiation. Edited by Cindy Sage and David O. Carpenter, BioInitiative, 2012, updated 2020. www.bioinitiative.org

Research Statistics by EMF Type

EMF TypeStudiesShowing EffectsPercentage
ELF22920891.00%
RF30522272.00%

Source: Dr. Henry Lai research database

Showing 2,030 studies

Mobile Phone Use and The Risk of Headache: A Systematic Review and Meta-analysis of Cross-sectional Studies.

Wang J, Su H, Xie W, Yu S. · 2017

Researchers performed a systematic review and meta-analysis of 7 cross-sectional studies on MP use and headache. The pooled analysis found a 38% increased risk of headache in MP users versus non-MP users. Among MP users, longer daily call duration and higher daily call frequency were each associated with greater headache risk.

Analysis of ear side of mobile phone use in the general population of Japan.

Sato Y, Kojimahara N, Taki M, Yamaguchi N · 2017

The study aimed to clarify the distribution of ear side of mobile phone use in Japan and factors associated with it. Statistically significant differences were observed only in talk time per call with an odds ratio of 2.17 and a 95% confidence interval of 1.22 to 3.99. In right-handed adults, left-ear use was significantly associated with age groups 30-39 (OR = 2.55; 95% CI: 1.79-3.68), 40-49 (OR = 3.08; 95% CI: 2.15-4.43), over 50 (OR = 1.85; 95% CI: 1.20-2.85), and with work-related talk time of 51-100% (OR = 1.75; 95% CI: 1.21-2.55). The survey included 2,518 children and 1,529 adults who completed an Internet-based survey, and data were analyzed by logistic regression. In children, the analysis focused on right-ear use in right-handed individuals due to dominant-hand tendency.

Mobile phone types and SAR characteristics of the human brain.

Lee AK, Hong SE, Kwon JH, Choi HD, Cardis E. · 2017

Researchers calculated specific absorption rate for four anatomical head models at different ages using 11 numerical phone models of different shapes and antenna configurations. The 11 models represented phone types accounting for around 86% of the approximately 1400 commercial phone models released into the Korean market since 2002. Seven of the phone models selected had an internal dual-band antenna and the remaining four had an external antenna. The 1 g peak spatial SAR and ipsilateral and contralateral brain-averaged SARs were reported for all 11 phone models, and the effects of phone type, phone position, operating frequency, and age of head models on brain SAR were comprehensively determined.

Mobile phones, cordless phones and rates of brain tumors in different age groups in the Swedish National Inpatient Register and the Swedish Cancer Register during 1998-2015.

Hardell L, Carlberg M. · 2017

Researchers analyzed brain tumor rates in the Swedish National Inpatient Register and Swedish Cancer Register from 1998 to 2015. The average annual percentage change for brain tumors increased by 2.06% per 100,000 in both genders combined. A joinpoint in 2007 showed a shift from a 0.16% annual change before 2007 to a 4.24% annual change after 2007. The highest increase was in the 20-39 year age group. The authors concluded that underreporting to the Cancer Register means real incidence is higher and trends should be used with caution.

Effects of radiofrequency exposure emitted from a GSM mobile phone on proliferation, differentiation, and apoptosis of neural stem cells.

Eghlidospour M, Ghanbari A, Mortazavi SMJ, Azari H. · 2017

Researchers exposed adult murine neural stem cells to GSM 900-MHz radiofrequency radiation from a mobile phone for varying durations. They used neurosphere assays to evaluate proliferation, immunofluorescence to examine differentiation, and alamarBlue and caspase 3 apoptosis assays to assess harmful effects. Neurosphere number and size and the proportion of cells becoming neurons decreased significantly with longer exposure. Cell viability, apoptosis, and astrocytic differentiation were unchanged.

Mobile phone use, school electromagnetic field levels and related symptoms: a cross-sectional survey among 2150 high school students in Izmir.

Durusoy R, Hassoy H, Özkurt A, Karababa AO. · 2017

Headache, fatigue, and sleep disturbances were reported 1.90, 1.78, and 1.53 times more often among mobile phone users. Dose-response relationships were found for call frequency, call duration, text message frequency, phone position at night, and charging while calling with symptoms such as headache, concentration difficulties, fatigue, sleep disturbances, ear warming, and flushing. No association was found between school EMF levels and symptoms, while limited associations were seen for proximity to base stations. Data were collected via questionnaire and EMF measurements from November 2009 to April 2011 using an Aaronia Spectran HF-4060 device.

Evaluation of Mobile Phone and Cordless Phone Use and Glioma Risk Using the Bradford Hill Viewpoints from 1965 on Association or Causation.

Carlberg M, Hardell L. · 2017

The authors evaluated glioma risk from mobile and cordless phone use using Bradford Hill's viewpoints. All nine viewpoints were evaluated based on epidemiology and laboratory studies. A meta-analysis of case-control studies found an odds ratio of 1.90 (95% CI 1.31-2.76) with highest cumulative exposure. Risk increased with latency, with an OR of 1.62 (95% CI 1.20-2.19) for 10+ years latency. Highest risk was in the 20+ years latency group, OR 2.01 (95% CI 1.41-2.88) for wireless phones.

Maternal cell phone use during pregnancy and child behavioral problems in five birth cohorts.

Birks L et al. · 2017

Researchers analyzed data from 83,884 mother-child pairs across five birth cohorts in Denmark, Korea, the Netherlands, Norway, and Spain. They categorized maternal cell phone use during pregnancy into none, low, medium, and high based on call frequency reported by mothers. Child behavioral problems were assessed using the Strengths and Difficulties Questionnaire or Child Behavior Checklist at ages 5–7 years. A trend of increasing risk of hyperactivity/inattention problems was observed across cell phone use categories, with odds ratios of 1.11 for medium users and 1.28 for high users. The association was consistent across cohorts and between prospective and retrospective data collection methods.

Long-term exposure to a continuous 900 MHz electromagnetic field disrupts cerebellar morphology in young adult male rats.

Aslan A, İkinci A, Baş O, Sönmez OF, Kaya H, Odacı E. · 2017

Researchers used three groups of six 21-day-old male rats, including an unexposed control, a sham-exposed group, and a group exposed to 900 MHz EMF for one hour daily from postnatal day 21 to 46. The EMF-exposed group had significantly fewer Purkinje cells than both the control and sham groups. Histopathological examination also showed altered Purkinje cell arrangement and intense cytoplasmic staining in the exposed rats.

Acute effects of the electromagnetic waves emitted by mobile phones on attention in emergency physicians.

Altuntas G et al. · 2017

The study was a single-center, prospective, randomized, double-blinded trial involving 30 emergency physicians randomly assigned to two groups. The control group held a mobile phone in 'off' mode to their left ear for 15 minutes, while the intervention group held a phone in 'on' mode, exposing them to 900-1800 MHz electromagnetic waves for the same period. Total performance, total figures marked, percentile, and attention fluctuation did not differ between groups, but the intervention group missed fewer figures, made fewer incorrect marks, and showed better focus.

Influence of the on-line ELF-EMF stimulation on the electrophysiological properties of the rat hippocampal CA1 neurons in vitro.

Zheng Y, Ma W, Dong L, Dou JR, Gao Y, Xue J. · 2017

Researchers studied the influence of on-line ELF-EMF stimulation on electrophysiological properties of rat hippocampal CA1 neurons in vitro. Modeling data and actual measurements showed similar magnetic flux densities from the stimulation coils. The stimulator induced sodium channel currents and field excitatory postsynaptic potentials in the neurons. Computational simulations in COMSOL modeling described the uniformity of the on-line magnetic field distribution.

Deep Brain Magnetic Stimulation Promotes Neurogenesis and Restores Cholinergic Activity in a Transgenic Mouse Model of Alzheimer's Disease.

Zhen J, Qian Y, Fu J, Su R, An H, Wang W , Zheng Y, Wang X. · 2017

Researchers investigated the effect of deep brain magnetic stimulation on spatial learning and memory, neurogenesis in the dentate gyrus, and cholinergic system expression and activity in a transgenic 5XFAD mouse model. Deep brain magnetic stimulation improved spatial learning and memory, enhanced neurogenesis in the hippocampal dentate gyrus, raised acetylcholine levels, and prevented increased acetylcholinesterase activity and decreased acetyltransferase activity in the hippocampus of 5XFAD mice. The authors concluded that deep brain magnetic stimulation may be a promising noninvasive tool for treating and preventing Alzheimer's disease cognitive impairment by promoting neurogenesis and enhancing cholinergic function.

Occupational exposure and amyotrophic lateral sclerosis in a prospective cohort.

Koeman T et al. · 2017

Researchers conducted a case-cohort analysis within the prospective Netherlands Cohort Study, following men and women aged 55-69 at enrolment in 1986 for 17.3 years on ALS mortality. Occupational exposure to solvents, pesticides, metals, extremely low frequency magnetic fields, and electrical shocks was estimated using job exposure matrices. Occupational exposure to ELF-MF showed a possible association with ALS mortality among men, with a hazard ratio of 2.19 for ever holding a high-exposure job and 1.93 for the highest cumulative exposure tertile.

Dopamine-dependent changes of cortical excitability induced by transcranial static magnetic field stimulation in Parkinson's disease.

Dileone M et al. · 2017

Researchers performed a randomized double-blind sham-controlled cross-over study applying tSMS for 10 minutes to the more affected motor cortex of Parkinson's disease patients. Cortical excitability was measured by motor evoked potential amplitude elicited by single-pulse transcranial magnetic stimulation. tSMS significantly decreased MEP amplitudes in patients off dopaminergic medication but not in patients on levodopa. Between-patient variability of tSMS-induced changes was significantly greater when patients were on medication. Greater disease progression was associated with a switch from inhibitory to facilitatory plasticity on medication.

Frequency-specific effects of repetitive magnetic stimulation on primary astrocyte cultures.

Clarke D et al. · 2017

Researchers tested four different repetitive magnetic stimulation frequencies on primary neonatal astrocyte cultures and measured calcium responses. Only 1 Hz stimulation produced a statistically significant rise in intracellular calcium in both cytoplasmic and nuclear compartments. This calcium increase did not change astrocyte migration or proliferation in a scratch assay. However, 1 Hz stimulation reduced astrocyte hypertrophy 24 hours after scratch injury. The authors concluded that the results provide preliminary evidence that repetitive magnetic stimulation can influence astrocyte physiology.

Static Magnetic Field Stimulation over Parietal Cortex Enhances Somatosensory Detection in Humans.

Carrasco-López C et al. · 2017

Researchers used noninvasive brain stimulation to modulate cortical network dynamics during neurophysiological and behavioral recordings. Parietal tSMS enhanced detection of near-threshold somatosensory stimuli. The improvement reflected decreased habituation to somatosensation. tSMS increased alpha oscillatory power without significantly affecting the early cortical component of somatosensory evoked potentials.

Rats exposed to 2.45GHz of non-ionizing radiation exhibit behavioral changes with increased brain expression of apoptotic caspase 3.

Varghese R, Majumdar A, Kumar G, Shukla A. · 2017

Researchers exposed female Sprague Dawley rats to 2.45GHz radiation for 4 hours per day for 45 days and assessed behavioral and oxidative stress parameters. Exposed rats exhibited memory decline and anxiety behavior in the Morris water maze, elevated plus maze, and light-dark box tests. Radiation exposure decreased brain antioxidant enzymes superoxide dismutase, catalase, and reduced glutathione, increased lipid peroxidation, and increased the apoptotic marker caspase 3, while histopathological examination and TNF-α levels showed no significant changes.

Effects of repeated restraint stress and WiFi signal exposure on behavior and oxidative stress in rats.

Othman H, Ammari M , Sakly M, Abdelmelek H. · 2017

Animals were divided into four groups: control, WiFi-exposed, restrained, and both WiFi-exposed and restrained, with each exposure occurring 2 h per day for 20 days. Tests included anxiety in the elevated plus maze, spatial learning in the water maze, cerebral oxidative stress response, and cholinesterase activity in brain and serum. WiFi exposure and restraint stress, alone and especially combined, induced anxiety-like behavior without impairing spatial learning and memory abilities. An oxidative stress response was triggered by WiFi and restraint, per se and especially when combined, as well as a WiFi-induced increase in acetylcholinesterase activity. There were no synergistic effects between WiFi signal and restraint stress on the brain.

Postnatal development and behavior effects of in-utero exposure of rats to radiofrequency waves emitted from conventional WiFi devices.

Othman H et al. · 2017

Researchers exposed pregnant rats to a 2.45 GHz WiFi signal for two hours daily throughout gestation. Offspring were assessed for physical and neurodevelopment during the first 17 postnatal days, anxiety at 28 days, motor behavior at 40-43 days, and cerebral oxidative stress and cholinesterase activity at 28 and 43 days. Prenatal WiFi exposure impaired early neurodevelopment but did not alter emotional or motor behavior in adulthood. It also increased oxidative stress markers and decreased antioxidant enzyme activities at 28 days but not at 43 days, and affected acetylcholinesterase activity in brain and serum.

The effect of 1800 MHz radio-frequency radiation on NMDA receptor subunit NR1 expression and peroxidation in the rat brain in healthy and inflammatory states.

Bodera P et al. · 2017

Researchers evaluated the effect of repeated 1800 MHz RFR exposure (5 times for 15 min) on NMDA-NR1 expression in rat brains in a persistent inflammatory state. They also measured the effect of RFR combined with tramadol to determine its potential antioxidant capacity. No differences in NMDA-NR1 expression were observed between baseline and RFR-exposed groups. NMDA-NR1 expression decreased after CFA injection combined with RFR exposure, while elevated expression was observed in healthy control rats exposed to RFR with or without tramadol. ORAC assessment revealed a robust effect of RFR, but other experiments showed equivocal effects.

Learn More

For a comprehensive exploration of EMF health effects including brain & nervous system, along with practical protection strategies, explore these books by R Blank and Dr. Martin Blank.

FAQs: EMF & Brain & Nervous System

When you review the peer-reviewed literature on electromagnetic field exposure and brain function, the numbers tell a compelling story: 84% of the 2,753 studies examining this relationship have documented measurable effects. This isn't a fringe concern or preliminary finding. This is the dominant scientific picture, and it deserves your attention. The documented effects span multiple systems within your nervous system.
The SYB Research Database includes 1,950 peer-reviewed studies examining the relationship between electromagnetic field exposure and brain & nervous system. These studies have been conducted by researchers worldwide and published in scientific journals. The research spans multiple decades and includes various types of EMF sources including cell phones, WiFi, power lines, and other common sources of electromagnetic radiation.
83% of the 1,950 studies examining brain & nervous system found measurable biological effects from EMF exposure. This means that 1621 studies documented observable changes in biological systems when exposed to electromagnetic fields. The remaining 17% either found no significant effects or had inconclusive results, which is typical in scientific research where study design and exposure parameters vary.