3,138 Studies Reviewed. 77.4% Found Biological Effects. The Evidence is Clear.
Research Guide

5G vs 4G Radiation: What's Different?

Based on 653 peer-reviewed studies

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People often ask whether 5G is more dangerous than 4G. This question requires understanding how 5G technology differs from previous generations and what research exists on each.

5G networks operate across multiple frequency bands. Low-band 5G (600-900 MHz) is actually similar to 4G frequencies. Mid-band 5G (2.5-4 GHz) overlaps with existing WiFi. High-band 5G (24-40+ GHz, "millimeter wave") represents the newest frequencies for consumer wireless exposure.

This page compares what research shows about radiation exposure from 5G versus 4G technologies.

Key Research Findings

  • 5G uses multiple frequency bands with different characteristics
  • Millimeter waves (high-band 5G) penetrate less deeply into tissue
  • More cell towers can actually reduce individual exposure levels

Related Studies (653)

Long-lasting (fatiguing) activity of isolated muscle fibres influenced by microwave electromagnetic field.

Radicheva N, Mileva K, Georgieva B, Kristev I · 2001

Researchers exposed isolated frog muscle fibers to 2.45 GHz microwave radiation (the same frequency used in WiFi and microwave ovens) at 20 mW/cm² for one hour. They found that the radiation altered how muscles respond to fatigue, making them more resistant to becoming tired during repeated contractions. This suggests that microwave radiation can directly affect muscle cell function through non-thermal mechanisms.

Tight junctional changes upon microwave and x-ray irradiation.

Palfia Z, Somosy Z, Rez G · 2001

Researchers exposed mice to microwave radiation (2.45 GHz at 1 mW/cm2 for 1 hour) and X-rays to study effects on tight junctions, which are cellular structures that control what passes between cells in the intestine. While X-rays damaged these protective barriers, microwave exposure actually strengthened them and increased calcium binding. This suggests that even low-level microwave radiation can alter fundamental cellular structures that control intestinal permeability.

Effects of radiofrequency exposure on the GABAergic system in the rat cerebellum: clues from semi-quantitative immunohistochemistry

Mausset A, de Seze R, Montpeyroux F, Privat A · 2001

French researchers exposed rats to 900 MHz radiofrequency radiation (the same frequency used by many cell phones) and measured changes in GABA, a crucial brain chemical that helps regulate nerve activity. They found that RF exposure reduced GABA levels in the cerebellum, the brain region responsible for movement and coordination. This suggests that cell phone radiation may disrupt normal brain chemistry at the cellular level.

[Effect of extremely high frequency electromagnetic radiation of low intensity on parameters of humoral immunity in healthy mice.]

Lushnikov KV, Gapeev AB, Sadovnikov VB, Cheremis NK. · 2001

Russian researchers exposed mice to 42 GHz radiation (millimeter waves like those in 5G) at low power levels. After 20 days of daily exposure, immune organs shrank significantly - the thymus by 17.5% and spleen by 14.5%, suggesting prolonged millimeter wave exposure may weaken immune system function.

Cellular Effects107 citations

Changes in cellular proteins due to environmental non-ionizing radiation. i. Heat-shock proteins.

Kwee S, Raskmark P, Velizarov P. · 2001

Researchers exposed human cells to extremely weak radiofrequency radiation (similar to cell phones) at levels 400 times below safety standards. They found that even this minimal exposure triggered the production of heat-shock proteins - cellular stress indicators that normally appear when cells are damaged or under threat. This demonstrates that biological effects can occur at radiation levels far below what regulators consider safe.

Cellular Effects107 citations

Changes in cellular proteins due to environmental non-ionizing radiation. I. Heat-shock protiens

S. Kwee, P. Raskmark & S. Velizarov · 2001

Danish researchers exposed human cells to weak 960 MHz microwave radiation (similar to cell phones) at extremely low power levels for 20 minutes. They found that cells produced significantly more heat-shock proteins (Hsp-70), which are cellular stress markers, even though the radiation was too weak to cause any heating. This suggests that cells can detect and respond to radiofrequency radiation through non-thermal biological mechanisms.

Effect of Exposure to 900 MHz Radiofrequency Radiation on Intrachromosomal Recombination in pKZ1 Mice.

Sykes PJ, McCallum BD, Bangay MJ, Hooker AM, Morley AA. · 2001

Researchers exposed mice to pulsed 900 MHz cell phone radiation for 30 minutes daily over different time periods to study effects on DNA recombination (the natural process where chromosomes exchange genetic material). After 25 days of exposure at 4 W/kg, they found a significant reduction in normal DNA recombination events in spleen tissue. This suggests that RF radiation can disrupt the cellular mechanisms that help repair DNA damage.

DNA & Genetic DamageNo Effects Found

Cytogenetic investigations on microwavesemitted by a 455.7 MHz car phone

Maes A, Collier M, Verschaeve L · 2000

Belgian researchers exposed human immune cells (lymphocytes) to radiation from a 455.7 MHz car phone at high intensity levels (6.5 W/kg SAR) to see if it would cause genetic damage or make the cells more vulnerable to other cancer-causing agents. They found no evidence that the phone radiation caused chromosome damage on its own, nor did it increase the harmful effects when combined with known mutagens like chemicals or X-rays.

Brain & Nervous SystemNo Effects Found

Effects of high peak power microwaves on the retina of the rhesus monkey.

Lu ST et al. · 2000

Researchers exposed rhesus monkeys to high-power microwave radiation (1.25 GHz) for 4 hours daily over 3 weeks to study effects on the retina (the light-sensitive tissue at the back of the eye). At moderate exposure levels (4.3 W/kg), they found no changes, but at higher levels (8.4-20.2 W/kg), some monkeys showed enhanced electrical responses in cone cells that detect color vision, though no actual damage occurred. The researchers concluded that retinal injury is very unlikely at 4 W/kg and that any changes at higher levels would likely be reversible.

DNA & Genetic DamageNo Effects Found

Primary DNA Damage in Human Blood Lymphocytes Exposed In Vitro to 2450 MHz Radiofrequency Radiation.

Vijayalaxmi, Leal BZ, Szilagyi M, Prihoda TJ, Meltz ML · 2000

Researchers exposed human blood cells to microwave radiation at 2450 MHz (the same frequency used in microwave ovens and some WiFi devices) for 2 hours to see if it would damage DNA. They found no evidence of DNA breaks or damage in the cells, even when they checked again 4 hours later to see if the cells could repair any potential damage. This suggests that this specific type and level of radiofrequency exposure may not cause immediate DNA harm.

Electromagnetic fields (1.8 GHz) increase the permeability to sucrose of the blood-brain barrier in vitro.

Schirmacher A et al. · 2000

Researchers exposed a laboratory model of the blood-brain barrier (the protective membrane that shields your brain from toxins in your blood) to cell phone radiation at 1.8 GHz. They found that this exposure significantly increased the barrier's permeability, allowing substances like sucrose to pass through more easily. This suggests that cell phone radiation may compromise the brain's natural protection system, potentially allowing harmful substances to reach brain tissue.

The simulation of the cooperative effect of development in a culture of early mouse embryos after irradiation with electromagnetic waves in the millimeter range.

Mezhevikina LM, Khramov RN, Lepikhov KA · 2000

Researchers exposed two-cell mouse embryos to millimeter wave electromagnetic radiation for 30 minutes and found the exposure stimulated the embryos to develop on their own without needing growth factors or serum. The treated embryos were able to reach the blastocyst stage (an important early developmental milestone) in laboratory culture conditions. This suggests millimeter waves can activate metabolic processes that control early embryonic development.

Oxidative stress precedes circulatory failure induced by 35-GHz microwave heating.

Kalns J, Ryan KL, Mason PA, Bruno JG, Gooden R, Kiel JL. · 2000

Researchers exposed rats to 35-GHz microwave radiation and measured oxidative stress markers (cellular damage from harmful molecules) in various organs. They found that even brief microwave exposure caused a 5- to 12-fold increase in oxidative stress markers in the lungs, liver, and blood plasma before any circulatory problems developed. This suggests that microwave radiation triggers widespread cellular damage throughout the body, even at exposure levels that don't immediately cause obvious health effects.

Zeeman-Stark modeling of the RF EMF interaction with ligand binding.

Chiabrera A, Bianco B, Moggia E, Kaufman JJ, · 2000

Researchers developed a quantum physics model to explain how radiofrequency electromagnetic fields might interfere with the way molecules bind to proteins inside cells. Their mathematical model suggests that RF radiation could disrupt these fundamental cellular processes when the energy of the electromagnetic waves matches specific protein structures. The findings indicate that current safety standards may need revision to account for these subtle but potentially significant biological interactions.

Ets1 oncogene induction by ELF-modulated 50 MHz radiofrequency electromagnetic field

Romano-Spica V, Mucci N, Ursini CL, Ianni A, Bhat NK · 2000

Italian researchers exposed blood and reproductive cells to radiofrequency radiation (50 MHz) combined with extremely low frequency modulation (16 Hz) to study effects on gene activity. They found that this specific combination activated the ets1 gene, which is associated with cancer development, but only when the low-frequency modulation was present. This suggests that the pulsing or modulation of RF signals may be more biologically active than continuous exposure.

Non-thermal effects of continuous 2.45 GHz microwaves on Fas-induced apoptosis in human Jurkat T-cell line.

Peinnequin A et al. · 2000

French researchers exposed human immune cells (T-cells) to 2.45 GHz microwave radiation for 48 hours at power levels well below heating thresholds. They found that this non-thermal microwave exposure interfered with a specific cellular death pathway called Fas-induced apoptosis, suggesting the radiation disrupted normal immune cell function at the molecular level.

Non-thermal heat-shock response to microwaves

de Pomerai D et al. · 2000

Researchers exposed tiny nematode worms to extremely low-power 750-MHz microwaves overnight and found increased production of heat shock proteins - cellular stress indicators that normally appear when organisms are damaged by heat or toxins. The microwave exposure was 1,000 times below current safety limits, yet still triggered this biological stress response, suggesting the effect was not caused by heating but by the electromagnetic fields themselves.

CardiovascularNo Effects Found

Membrane potential and currents of isolated heart muscle cells exposed to pulsed radio frequency fields.

Linz et al. · 1999

German researchers exposed isolated heart muscle cells from guinea pigs and rats to cell phone frequencies (900 MHz and 1800 MHz) to see if radio waves affected the cells' electrical activity. They found no significant changes to the heart cells' membrane potential, action potentials, or calcium and potassium currents even at exposure levels up to 880 mW/kg. The study suggests that cell phone radiation at these levels does not directly disrupt the basic electrical functions of heart muscle cells.

Cancer & TumorsNo Effects Found

TP53 tumor suppressor protein in normal human fibroblasts does not respond to 837 MHz microwave exposure.

Li et al. · 1999

Researchers exposed human cells to 837 MHz microwave radiation (the frequency used by early cell phones) for 2 hours at power levels ranging from 0.9 to 9.0 W/kg. They measured levels of TP53, a critical protein that normally increases when cells are damaged and helps prevent cancer formation. The study found no changes in TP53 levels up to 48 hours after exposure, suggesting these microwave frequencies did not trigger the cellular damage response.

DNA & Genetic DamageNo Effects Found

Proto-oncogene mRNA levels and activities of multiple transcription factors in C3H 10T 1/2 murine embryonic fibroblasts exposed to 835.62 and 847.74 MHz cellular phone communication frequency radiation.

Goswami PC et al. · 1999

Researchers exposed mouse cells to cellular phone radiation at 835 MHz and 847 MHz (similar to early cell phones) to see if it triggered stress responses. While most stress indicators showed no change, one specific gene called Fos increased by 40-100% in exposed cells. This suggests cell phone radiation can alter gene activity even when it doesn't cause obvious cellular stress.

Immune SystemNo Effects Found

[Stimulation of murine natural killer cells by weak electromagnetic waves in the centimeter range].

Fesenko EE et al. · 1999

Russian researchers exposed mice to weak microwave radiation (8.15-18 GHz) for 24-72 hours and found their natural killer cells - immune cells that fight cancer and infections - became 130-150% more active. The immune boost lasted at least 24 hours after exposure ended, but shorter exposures of just a few hours showed no effect.

Cellular Effects186 citations

The effects of radiofrequency fields on cell proliferation are non-thermal.

Velizarov, S, Raskmark, P, Kwee, S, · 1999

Researchers exposed cells to 960 MHz radiofrequency radiation (similar to cell phone signals) at different temperatures to test whether heat alone causes biological effects. They found that RF radiation altered cell growth patterns at both higher and lower temperatures, proving that the effects weren't simply due to heating. This challenges the mainstream assumption that only thermal effects from wireless radiation can impact living cells.

IRIDIUM exposure increases c-fos expression in the mouse brain only at levels which likely result in tissue heating.

Morrissey JJ et al. · 1999

Researchers exposed mice to 1.6-GHz radiofrequency signals (similar to satellite phone frequencies) for one hour to see if it affected brain activity. They found that brain changes only occurred at exposure levels 6-30 times higher than current safety limits for cell phones, and these changes appeared to be caused by tissue heating rather than direct effects from the radiation itself.

[Two-step exposure of biological objects to infrared laser and microwave radiation].

Kol'tsov IuV, Korolev VN, Kusakin SA, · 1999

Researchers exposed bacteria to both infrared laser light and microwave radiation to see how the two types of energy interact. They found that microwave radiation significantly amplifies the biological effects of laser radiation, even though microwaves alone required much lower doses to trigger cellular responses. This suggests that combining different types of electromagnetic energy can produce stronger biological effects than either type alone.

Further Reading

For a comprehensive exploration of EMF health effects and practical protection strategies, explore these books by R Blank and Dr. Martin Blank.