3,138 Studies Reviewed. 77.4% Found Biological Effects. The Evidence is Clear.
Research Guide

5G vs 4G Radiation: What's Different?

Based on 653 peer-reviewed studies

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People often ask whether 5G is more dangerous than 4G. This question requires understanding how 5G technology differs from previous generations and what research exists on each.

5G networks operate across multiple frequency bands. Low-band 5G (600-900 MHz) is actually similar to 4G frequencies. Mid-band 5G (2.5-4 GHz) overlaps with existing WiFi. High-band 5G (24-40+ GHz, "millimeter wave") represents the newest frequencies for consumer wireless exposure.

This page compares what research shows about radiation exposure from 5G versus 4G technologies.

Key Research Findings

  • 5G uses multiple frequency bands with different characteristics
  • Millimeter waves (high-band 5G) penetrate less deeply into tissue
  • More cell towers can actually reduce individual exposure levels

Related Studies (653)

Effect of amplitude modulated RF radiation on calcium ion efflux and ODC activity in chronically exposed rat brain.

Paul Raj R, Behari J, Rao AR · 1999

Researchers exposed young rats to radiofrequency radiation at cell phone-like levels for 35 days and found significant changes in brain chemistry, including increased calcium movement and enzyme activity. These cellular changes in developing brains suggest RF exposure during growth may disrupt normal brain function.

Microwaves and cellular immunity. II. Immunostimulating effects of microwaves and naturally occurring antioxidant nutrients

Novoselova, EG, Fesenko, EE, Makar, VR, Sadovnikov, VB · 1999

Russian researchers exposed mice to very low-level microwave radiation (similar to what cell towers emit) for 5 hours and found it significantly boosted immune system activity. The microwaves increased production of tumor necrosis factor (TNF), a key immune signaling molecule, in immune cells called macrophages and T-cells. This immune activation lasted for at least 3 days after exposure and was enhanced when mice were given antioxidant nutrients.

Microwaves and cellular immunity: II. Immunostimulating effects of microwaves and naturally occurring antioxidant nutrients

E.G Novoselova, E.E Fesenko, V.R Makar, V.B Sadovnikov · 1999

Researchers exposed mice to extremely low-power microwave radiation (8.15-18 GHz) for 5 hours and found it actually stimulated their immune systems, increasing production of immune signaling molecules and enhancing T cell activity. The immune boost was further enhanced when mice were given antioxidant nutrients like vitamin E and beta-carotene. This suggests that very low-level microwave exposure might trigger beneficial immune responses rather than suppress immunity.

[Stimulation of murine natural killer cells by weak electromagnetic waves in the centimeter range].

Fesenko EE et al. · 1999

Russian researchers exposed mice to extremely low-power microwave radiation (8.15-18 GHz at 1 microW/cm²) for 24-72 hours and found their natural killer cells became 130-150% more active. Natural killer cells are immune system defenders that destroy cancer cells and virus-infected cells. The immune boost lasted 24 hours after exposure ended, but shorter exposures of 3-5 hours showed no effect.

Microwaves and cellular immunity. I. Effect of whole body microwave irradiation on tumor necrosis factor production in mouse cells.

Fesenko EE, Makar VR, Novoselova EG, Sadovnikov VB. · 1999

Researchers exposed mice to extremely low-level microwave radiation (8.15-18 GHz at just 1 microW/cm²) and found it significantly boosted production of TNF (tumor necrosis factor), a key immune system protein. Short-term exposure for 5 hours to 3 days enhanced immune cell activity, but chronic exposure for 7 days actually suppressed it. This demonstrates that even ultra-weak microwave radiation can measurably alter immune system function in living organisms.

[Effect of millimeter waves on the early development of the mouse and sea urchin embryo].

Galat VV et al. · 1999

Russian researchers exposed mouse and sea urchin embryos to millimeter wave radiation (54-78 GHz) at very low power levels for 30 minutes during early development. They found that exposed mouse embryos developed faster and more successfully reached the blastocyst stage compared to unexposed controls. The radiation appeared to strengthen embryos against environmental stress, suggesting these frequencies may have biological effects even at non-thermal levels.

Microwaves and cellular immunity. I. Effect of whole body microwave irradiation on tumor necrosis factor production in mouse cells.

Fesenko, EE, Makar, VR, Novoselova, EG, Sadovnikov, VB, · 1999

Russian researchers exposed mice to low-level microwave radiation and found it significantly altered immune system function. Short exposures boosted immune cell activity, while longer exposure suppressed it. These effects persisted for days after radiation ended, showing even weak microwaves can disrupt normal immunity.

Immune SystemNo Effects Found

[Levels of immunoglobulin and subpopulations of T lymphocytes and NK cells in men occupationally exposed to microwave radiation in frequencies of 6-12 GHz].

Dmoch A, Moszczynski P · 1998

Polish researchers studied immune system function in workers exposed to microwave radiation from TV transmission and satellite communication equipment (6-12 GHz frequencies). They found several changes in immune cell populations and antibody levels, including increased immunoglobulins (infection-fighting proteins) and altered ratios of different white blood cell types. However, the authors concluded these changes had no clinical significance, meaning they didn't appear to cause actual health problems.

Microwave irradiation influences on the state of human cell nuclei.

Shckorbatov YG et al. · 1998

Ukrainian researchers exposed human cheek cells to millimeter wave radiation at 42.2 GHz and found it altered the cells' nuclei in two key ways: it reduced the electrical charge of the cell nucleus and increased chromatin condensation (DNA packaging became tighter). The effects varied based on radiation dose and individual differences between cell donors, suggesting that millimeter wave exposure can directly impact cellular structures at the genetic level.

Cellular phone effects on otoacoustic emissions.

Grisanti G et al. · 1998

Italian researchers studied how cellular phone radiation affects the inner ear by measuring otoacoustic emissions (tiny sounds the ear produces naturally). They found that the electromagnetic fields from phones altered these natural ear responses in nearly all test subjects. This suggests that phone radiation can interfere with normal inner ear function, potentially affecting hearing.

Stimulation of production of tumor necrosis factor by murine macrophages when exposed in vio and in vitro to weak electromagnetic waves in the centimeter range

Novoselova ET, Fesenko EE. · 1998

Russian researchers exposed mice to extremely weak microwave radiation (8.15-18 GHz) at power levels 1,000 times lower than cell phones. The exposure significantly increased production of tumor necrosis factor, a key immune protein, suggesting even very low-level microwaves can alter immune function.

[Stimulation of production of tumor necrosis factor by murine macrophages when exposed in vio and in vitro to weak electromagnetic waves in the centimeter range].

Novoselova ET, Fesenko EE. · 1998

Russian researchers exposed mice to extremely weak microwave radiation (8.15-18 GHz at 1 microW/cm²) and found it significantly increased production of tumor necrosis factor in immune cells called macrophages. Tumor necrosis factor is a key protein that triggers inflammation and immune responses in the body. This suggests that even very low-power microwave radiation can alter immune system function.

Interaction of low level modulated RF radiation with Na+¯K+-ATPase.

Behari J, Kunjilwar KK, and Pyne S · 1998

Researchers exposed developing rats to radiofrequency radiation similar to what cell phones emit and found it significantly increased activity of a critical brain enzyme called Na+-K+-ATPase by 15-20%. This enzyme is essential for nerve cell function and brain development. The findings suggest that RF radiation can alter fundamental brain chemistry in developing animals, raising concerns about potential effects on brain development in children.

DNA damage in Molt-4 T- lymphoblastoid cells exposed to cellular telephone radiofrequency fields in vitro.

Phillips et al. · 1998

Researchers exposed immune system cells to radiofrequency radiation from cell phone signals at extremely low power levels for 2 to 21 hours. They found that very low exposures actually reduced DNA damage, while slightly higher exposures increased DNA breaks in the cellular genetic material. This suggests that even minimal RF radiation can alter DNA integrity in immune cells, though the effects varied depending on the specific exposure level.

DNA & Genetic DamageNo Effects Found

Proliferation and cytogenetic studies in human blood lymphocytes exposed in vitro to 2450 MHz radiofrequency radiation.

Vijayalaxmi, Mohan, N, Meltz, ML, Wittler, MA, · 1997

Researchers exposed human blood cells to microwave radiation at 2450 MHz (the same frequency used in microwave ovens and WiFi) for 90 minutes to see if it would damage DNA or affect cell growth. They found no genetic damage, chromosome breaks, or changes in how fast the cells multiplied compared to unexposed cells. This suggests that short-term exposure to this type of radiation at these power levels may not immediately harm human blood cells.

Cancer & TumorsNo Effects Found

DNA synthesis and cell proliferation in C6 glioma and primary glial cells exposed to a 836.55 MHz modulated radiofrequency field.

Stagg RB, Thomas WJ, Jones RA, Adey WR · 1997

Researchers exposed brain cells (both normal and cancerous glioma cells) to cell phone-like radiofrequency radiation at 836.55 MHz for 24 hours to see if it would promote tumor growth by affecting DNA synthesis. While they found small increases in DNA activity in some cancer cell experiments, this didn't translate to actual increased cell growth or proliferation in either normal or cancerous cells.

DNA & Genetic DamageNo Effects Found136 citations

Measurement of DNA damage after exposure to electromagnetic radiation in the cellular phone communication frequency band (835.62 and 847.74 MHz).

Malyapa RS et al. · 1997

Researchers exposed mouse and human cells to cell phone frequencies (835-847 MHz) for up to 24 hours at power levels similar to phone use to see if the radiation damaged DNA. Using a sensitive test called the comet assay, they found no DNA damage in the exposed cells compared to unexposed control cells. This suggests that cell phone radiation at typical exposure levels may not directly break DNA strands in laboratory conditions.

Reproductive HealthNo Effects Found

The lack of effects of nonthermal RF electromagnetic fields on the development of rat embryos grown in culture.

Klug S, Hetscher M, Giles S, Kohlsmann S, Kramer K, · 1997

German researchers exposed developing rat embryos to radio frequency electromagnetic fields at various power levels for up to 36 hours to test whether EMF exposure during critical development stages causes birth defects or growth problems. The study found no significant effects on embryo development, growth, or cellular structure across all tested exposure levels, including levels far exceeding typical telecommunication device emissions. This suggests that RF fields at these intensities may not pose developmental risks during embryonic growth.

Brain & Nervous SystemNo Effects Found

Exposure of nerve growth factor-treated PC12 rat pheochromocytoma cells to a modulated radiofrequency field at 836.55 MHz: effects on c-jun and c-fos expression.

Ivaschuk OI et al. · 1997

Researchers exposed rat nerve cells to cell phone radiation at 836.55 MHz (the frequency used by early digital cell phones) to see if it would affect the activity of genes called c-fos and c-jun, which help control cell growth and responses to stress. They found mostly no effects, except for a 38% decrease in c-jun gene activity at the highest exposure level of 9 mW/cm². This suggests that cell phone radiation may have subtle effects on nerve cell gene expression, but only at relatively high exposure levels.

Cancer & TumorsNo Effects Found

Focus formation of C3H/10T1/2 cells and exposure to a 836.55 MHz modulated radiofrequency field.

Cain CD, Thomas DL, Adey WR · 1997

Researchers exposed mouse cells to cell phone-like radiation (836.55 MHz TDMA signals) for 28 days to see if it would enhance cancer cell formation when combined with a known tumor-promoting chemical. The radiation exposure at levels similar to cell phone use did not increase cancer cell formation compared to unexposed cells. This suggests that this type of radiofrequency exposure does not act as a tumor promoter in laboratory cell cultures.

DNA & Genetic DamageNo Effects Found

Measurement of DNA damage after exposure to electromagnetic radiation in the cellular phone communication frequency band (835.62 and 847.74 MHz).

Malyapa RS et al. · 1997

Researchers exposed two types of cells (mouse and human) to cell phone radiation at frequencies used by mobile phones (835-847 MHz) for up to 24 hours to see if it caused DNA damage. They found no DNA damage in either cell type when exposed at a specific absorption rate (SAR) of 0.6 W/kg, which is below current regulatory limits. This suggests that cell phone radiation at this level may not directly break DNA strands in laboratory conditions.

Cytogenetic effects of 935.2-MHz (GSM) microwaves alone and in combination with mitomycin C.

Maes A, Collier M, Van Gorp U, Vandoninck S, Verschaeve L · 1997

Researchers exposed human blood cells to 935.2 MHz microwaves (the same frequency used by GSM cell phones) to test whether this radiation could damage DNA or chromosomes. They found no direct genetic damage from the microwaves alone, but discovered a very weak increase in DNA damage when cells were exposed to both microwaves and a known cancer-causing chemical called mitomycin C.

Effects of electromagnetic radiation on embryos of sea-urchins.

Koldayev VM, Shchepin YV, · 1997

Researchers exposed sea urchin embryos to electromagnetic radiation and found it reduced successful fertilization rates while increasing abnormal development. The study revealed that EMR damaged cell membranes, increased harmful oxidation, and disrupted normal cellular processes during early embryonic development. This demonstrates that electromagnetic fields can interfere with fundamental reproductive processes at the cellular level.

Further Reading

For a comprehensive exploration of EMF health effects and practical protection strategies, explore these books by R Blank and Dr. Martin Blank.