3,138 Studies Reviewed. 77.4% Found Biological Effects. The Evidence is Clear.

EMF Research Studies

Browse 3,138 peer-reviewed studies on electromagnetic field health effects from the BioInitiative Report database.

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Showing 1,644 studies in Brain & Nervous System

Effects of Electromagnetic Radiation from Smartphones on Learning Ability and Hippocampal Progenitor Cell Proliferation in Mice

Choi Y-J, Choi Y-S · 2016

Researchers exposed mice to smartphone electromagnetic radiation for 9-11 weeks to study effects on brain function and memory. While the radiation didn't impair spatial memory or damage brain cell growth, it did activate astrocytes (brain support cells that respond to injury) and caused hyperactivity-like behavior weeks after exposure ended. This suggests smartphone radiation may trigger subtle brain changes that aren't immediately obvious but could have delayed effects.

Activity and expression of acetylcholinesterase in PC12 cells exposed to intermittent 1.8 GHz 217-GSM mobile phone signal.

Valbonesi P, Franzellitti S, Bersani F, Contin A, Fabbri E. · 2016

Italian researchers exposed rat brain cells to cell phone radiation at the legal safety limit for 24 hours and found that a key brain enzyme called acetylcholinesterase increased by 40%. This enzyme is crucial for memory, learning, and proper brain function, and disruptions to it are linked to neurodegenerative diseases like Alzheimer's.

Effects of pre- and postnatal exposure to 1880-1900MHz DECT base radiation on development in the rat.

Stasinopoulou M et al. · 2016

Researchers exposed pregnant rats to DECT phone base station radiation (the same frequency as cordless phones) for 12 hours daily during pregnancy and early life. They found increased heart rates in developing embryos, altered birth measurements in newborns, and significant brain cell loss in the hippocampus region of 22-day-old pups. These brain changes occurred whether the animals were exposed only before birth or both before and after birth.

Neurobehavioural Changes and Brain Oxidative Stress Induced by Acute Exposure to GSM900 Mobile Phone Radiations in Zebrafish (Danio rerio).

Nirwane A, Sridhar V, Majumdar A · 2016

Researchers exposed zebrafish to cell phone radiation (GSM 900 MHz) for 14 days at human-equivalent levels. The fish developed increased anxiety, reduced social behavior, and impaired learning, plus brain oxidative stress indicating cellular damage. This suggests everyday cell phone radiation may affect brain function.

Neurobiological effects of repeated radiofrequency exposures in male senescent rats.

Bouji M, Lecomte A, Gamez C, Blazy K, Villégier AS. · 2016

Researchers exposed both young and elderly rats to cell phone radiation (900 MHz) for 45 minutes daily over one month to see if aging brains were more vulnerable to EMF effects. The study found that while elderly rats showed expected age-related brain problems, the radiation exposure didn't make these problems worse. Interestingly, both young and old rats exposed to radiation showed reduced anxiety-like behaviors.

Glial markers and emotional memory in rats following acute cerebral radiofrequency exposures.

Barthélémy A et al. · 2016

Researchers exposed rats to radiofrequency radiation for 15 minutes at different intensities and measured brain inflammation and memory function. They found that even low-level exposure (1.5 W/kg) caused significant brain inflammation, while higher exposure (6 W/kg) impaired long-term memory and increased inflammation in multiple brain regions. This study provides direct evidence that brief RF exposure can trigger brain inflammation and memory problems in living animals.

Exposure to extremely low frequency electromagnetic fields alters the behaviour, physiology and stress protein levels of desert locusts.

Wyszkowska J, Shepherd S, Sharkh S, Jackson CW, Newland PL. · 2016

Scientists exposed desert locusts to electromagnetic fields from power lines and appliances, finding reduced walking ability, slower nerve responses, weaker muscle contractions, and increased cellular stress proteins. This demonstrates that everyday electromagnetic field exposure can cause measurable biological effects across multiple body systems.

Magnetoreception Regulates Male Courtship Activity in Drosophila.

Wu CL, Fu TF, Chiang MH, Chang YW, Her JL, Wu T. · 2016

Researchers exposed male fruit flies to static magnetic fields as low as 20 Gauss (about 40 times Earth's natural magnetic field) and found it significantly increased their courtship behavior. The effect depended on cryptochrome, a protein that helps animals sense magnetic fields and is also found in humans. This study demonstrates that relatively weak magnetic fields can alter behavior through biological magnetic sensing mechanisms.

Involvement of NMDA receptor in low-frequency magnetic field-induced anxiety in mice.

Salunke BP, Umathe SN, Chavan JG. · 2016

Researchers exposed mice to 50 Hz magnetic fields (the same frequency as power lines) for up to 120 days and found it caused significant anxiety-like behavior. The study identified that these fields disrupt brain chemistry by affecting NMDA receptors and increasing glutamate levels in key brain regions. This suggests that long-term exposure to power-frequency magnetic fields can alter brain function and behavior.

The Cytome Assay as a Tool to Investigate the Possible Association Between Exposure to Extremely Low Frequency Magnetic Fields and an Increased Risk for Alzheimer's Disease.

Maes A, Anthonissen R, Wambacq S, Simons K, Verschaeve L. · 2016

Scientists exposed cells to 50 Hz magnetic fields from power lines at levels above 50 microtesla and found genetic damage patterns similar to Alzheimer's patients. The exposure caused chromosome instability in cells, suggesting a possible biological link between power line magnetic fields and Alzheimer's disease development.

Effects of short term and long term Extremely Low Frequency Magnetic Field on depressive disorder in mice: Involvement of nitric oxide pathway.

Madjid Ansari A et al. · 2016

Researchers exposed mice to extremely low frequency magnetic fields (the type generated by power lines and electrical appliances) to study effects on depression-like behavior. They found that short-term exposure (2 hours) had no effect, but long-term exposure (2 hours daily for 2 weeks) actually reduced depressive symptoms in the mice. The study suggests this effect may work through changes in nitric oxide levels in the brain.

Extremely Low-Frequency Electromagnetic Fields Promote In Vitro Neuronal Differentiation and Neurite Outgrowth of Embryonic Neural Stem Cells via Up-Regulating TRPC1.

Ma Q et al. · 2016

Researchers exposed embryonic brain stem cells to 50 Hz electromagnetic fields from power lines and electrical devices. The EMF exposure significantly enhanced the cells' development into neurons and promoted growth of neural connections. This suggests electromagnetic fields could influence brain formation during early development.

Long-term exposure to ELF-MF ameliorates cognitive deficits and attenuates tau hyperphosphorylation in 3xTg AD mice.

Hu Y et al. · 2016

Researchers exposed genetically modified mice with Alzheimer's disease to extremely low frequency magnetic fields (50Hz, 500μT) for three months daily. The magnetic field exposure improved cognitive function, reduced brain cell death, and decreased tau protein abnormalities that are hallmarks of Alzheimer's disease. This suggests that controlled magnetic field exposure might have therapeutic potential for neurodegenerative conditions.

The developmental effects of extremely low frequency electric fields on visual and somatosensory evoked potentials in adult rats.

Gok DK et al. · 2016

Scientists exposed pregnant rats to 50 Hz electric fields from power lines and tested their offspring's brain responses as adults. The exposed rats showed delayed neural processing for vision and touch, plus increased brain damage markers, suggesting developmental electric field exposure causes lasting nervous system changes.

Improved Mitochondrial and Methylglyoxal-Related Metabolisms Support Hyperproliferation Induced by 50 Hz Magnetic Field in Neuroblastoma Cells.

Falone S et al. · 2016

Researchers exposed human neuroblastoma cells (a type of brain cancer cell) to 50 Hz magnetic fields at 1 milliTesla and found the fields made the cancer cells grow faster and become more aggressive. The magnetic field exposure triggered protective mechanisms in the cancer cells that helped them survive and multiply more effectively. This suggests that power frequency magnetic fields might promote the growth of existing brain tumors.

Competition between hydrogen bonding and protein aggregation in neuronal-like cells under exposure to 50 Hz magnetic field.

Calabrò E. · 2016

Researchers exposed human brain-like cells to a 50 Hz magnetic field (the type emitted by power lines and household appliances) for 4 hours and found significant changes in cellular proteins. The magnetic field caused proteins to clump together abnormally and altered their structural bonds, which are critical for proper brain cell function. These molecular changes suggest that everyday electromagnetic fields may disrupt normal cellular processes in brain tissue.

Effects of short term and long term extremely low frequency magnetic field on depressive disorder in mice: Involvement of nitric oxide pathway.

Ansari AM et al. · 2016

Researchers exposed mice to extremely low frequency magnetic fields (the type emitted by power lines and electrical devices) for either 2 hours once or 2 hours daily for 2 weeks. They found that long-term exposure reduced depression-like behavior in the mice, while short-term exposure interfered with antidepressant medications. This suggests that chronic EMF exposure may alter brain chemistry and affect how psychiatric medications work.

The 2100MHz radiofrequency radiation of a 3G-mobile phone and the DNA oxidative damage in brain.

Şahin D et al. · 2016

Researchers exposed female rats to 3G mobile phone radiation (2100 MHz) for either 10 or 40 days to study DNA damage in brain tissue. They found increased DNA damage after 10 days of exposure, but surprisingly, this damage decreased after 40 days, suggesting the brain may develop protective mechanisms over time. The study used radiation levels similar to what you'd experience during heavy mobile phone use.

Neurobehavioural Changes and Brain Oxidative Stress Induced by Acute Exposure to GSM900 Mobile Phone Radiations in Zebrafish (Danio rerio).

Nirwane A, Sridhar V, Majumdar A. · 2016

Researchers exposed zebrafish to cell phone radiation at levels similar to those from mobile phones (1.34 W/kg SAR) for one hour daily over two weeks. The fish showed increased anxiety-like behaviors, impaired learning ability, and brain damage from oxidative stress. This study demonstrates that even brief daily exposure to mobile phone radiation can alter brain function and damage brain cells.

Effects of cell phone radiation on lipid peroxidation, glutathione and nitric oxide levels in mouse brain during epileptic seizure

Esmekaya MA et al. · 2016

Researchers exposed mice to cell phone radiation (900 MHz) before, during, and after chemically-induced seizures to study brain effects. They found that radiation exposure significantly increased oxidative damage and inflammatory markers in brain tissue compared to seizures alone. This suggests cell phone radiation may worsen brain vulnerability during neurological stress, potentially making seizure-related brain damage more severe.

Neuroprotective effects of lotus seedpod procyanidins on extremely low frequency electromagnetic field-induced neurotoxicity in primary cultured hippocampal neurons.

Yin C, Luo X, Duan Y, Duan W, Zhang H, He Y, Sun G, Sun X · 2016

Researchers exposed rat brain cells to 50 Hz magnetic fields and found significant damage including cell death and DNA harm. However, natural compounds from lotus seed pods prevented most of this damage, suggesting magnetic fields can harm brain cells but certain antioxidants may offer protection.

Electromagnetic pulse activated brain microglia via the p38 MAPK pathway

Yang LL et al. · 2016

Researchers exposed rats to electromagnetic pulses (EMP) at extremely high levels and found that these exposures activated microglia, the brain's immune cells, causing inflammation. The study identified that this brain immune response happened through a specific cellular pathway called p38 MAPK, and the effects were measurable within hours of exposure. This research helps explain one biological mechanism by which electromagnetic fields might affect brain function.

Chemoprotective action of lotus seedpod procyanidins on oxidative stress in mice induced by extremely low-frequency electromagnetic field exposure.

Luo X et al. · 2016

Researchers exposed mice to extremely low frequency electromagnetic fields (the type from power lines and appliances) for 4 hours daily for 28 days and found it caused oxidative stress damage in their brains. However, when mice were given lotus seed extract before and during exposure, the natural antioxidants significantly protected against this cellular damage by boosting the body's natural defense systems.

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