Mazor R et al. · 2008
Researchers exposed human peripheral blood lymphocytes from 10 samples to radiofrequency electromagnetic fields at 800 MHz for 72 hours in a waveguide resonator at specific absorption rates of 2.9 and 4.1 W/kg. The study found increased levels of aneuploidy depending on the chromosome studied and the level of exposure, with chromosomal gains appearing to be the primary contributor. Temperature was tested over a range of 33.5–40°C for 72 hours and showed no statistically significant difference in aneuploidy levels compared to 37°C, suggesting the effect may not be due to heating.
Manti L et al. · 2008
Researchers exposed human peripheral blood lymphocytes in vitro to a UMTS signal at a frequency carrier of 1.95 GHz for 24 hours at 0.5 and 2.0 W/kg SAR. Cells were also given 4 Gy of X rays immediately before RF radiation or sham exposures, and chromosome aberrations were measured by fluorescence in situ hybridization. No significant variations due to the UMTS exposure were found in the fraction of aberrant cells, but the frequency of exchanges per cell showed a small but statistically significant increase of 0.11 exchange per cell compared to 0 W/kg SAR.
Unknown authors · 2007
Researchers exposed murine L929 fibroblasts, rat C6 glioblastoma cells, human SH-SY5Y neuroblastoma cells, and rat primary astrocytes to 872 MHz RF radiation. Cells were exposed for 2, 8, or 24 hours to continuous wave or GSM-modulated signals at specific absorption rates of 1.5, 2.5, or 6.0 W/kg. ODC activity in rat primary astrocytes decreased significantly at 1.5 and 6.0 W/kg with both signal types. Secondary cell lines showed generally no change in ODC activity.
Sanchez et al. · 2007
The study investigated heat-shock protein expression and apoptosis in human primary keratinocytes and fibroblasts. The exposure used a GSM-1800 signal at 1800 MHz with 217 Hz modulation for 48 hours at an SAR of 2 W/kg. The GSM-1800 exposure produced no effect on either cell type, while UVB radiation and heat shock injured cells. The authors concluded that the GSM-1800 signal does not act as a stress factor on human primary skin cells in vitro.
Ribeiro EP, Rhoden EL, Horn MM, Rhoden C, Lima LP, Toniolo L · 2007
Researchers randomly divided 16 male Wistar rats into experimental and control groups; the experimental group was exposed to GSM radiofrequency (1,835–1,850 MHz) for 1 hour daily over 11 weeks. They measured rectal temperature, testicular and epididymal weight, lipid peroxidation, serum testosterone, sperm count, and histopathological endpoints. No statistically significant differences were found between exposed and control groups in any measured endpoint.
Chauhan V et al. · 2007
Researchers exposed human-derived cell lines TK6, HL60, and Mono-Mac-6 to intermittent 1.9 GHz pulse-modulated RF fields for 6 hours at SARs of 0, 1, and 10 W/kg. Cell viability, apoptosis, and cell cycle kinetics were measured immediately after exposure and 18 hours later. Cytokine expression (TNFA, IL1B, IL6, IL8, IL10, IL12) was also assessed. No detectable changes in cell viability, cell cycle kinetics, apoptosis, or cytokine expression were observed in any exposed group compared to sham controls. The positive heat-shock control showed decreased viability, increased apoptosis, and a G(2)/M cell cycle block.
Chauhan V et al. · 2007
Researchers examined the effect of RF field exposure on late onset gene expression in U87MG cells after a 24 h exposure period. A human monocyte-derived cell line (MM6) was exposed to intermittent RF fields for 6 h and gene expression was assessed immediately and at 18 h postexposure. Both cell lines were exposed to 1.9 GHz pulse-modulated RF fields for 6 or 24 h at SARs of 0.1-10.0 W/kg. The study found no evidence that nonthermal RF field exposure altered gene expression in either U87MG or MM6 cells relative to nonirradiated controls. Heat shock at 43°C for 1 h altered the expression of well-characterized heat-shock proteins in both cell lines.
Speit G, Schütz P, Hoffmann H. · 2007
Researchers exposed ES1 cells to 1800 MHz RF-EMF at 2 W/kg SAR with intermittent exposure and tested for DNA damage using the alkaline comet assay and micronucleus test. They also tested V79 Chinese hamster cells and found no genotoxic effect in either assay. Quality control measures were used to rule out test performance issues, exposure failure, or evaluation bias.
Platano D et al. · 2007
Researchers studied the non-thermal effects of radiofrequency electromagnetic fields on barium currents through voltage-gated calcium channels in primary cultures of rat cortical neurons using the patch-clamp technique. Neurons were exposed for one to three periods of 90 seconds to 900 MHz continuous wave or GSM-modulated signals during whole-cell recording at specific absorption rates of 2 W/kg for both modulation types. Single or multiple acute exposures to either continuous wave or GSM-modulated 900 MHz fields did not significantly alter the current amplitude or the current-voltage relationship through voltage-gated calcium channels.
Joubert V, Leveque P, Cueille M, Bourthoumieu S, Yardin C. · 2007
Researchers exposed primary cultured neurons from embryonic Wistar rat cortices to a 900-MHz GSM field for 24 hours at 0.25 W/kg SAR. Apoptosis was measured immediately and 24 hours after exposure using DAPI staining, TUNEL/PI flow cytometry, and caspase-3 fluorimetry. No statistically significant difference in apoptosis rate was found between exposed and control neurons at either time point. All three assessment methods gave concordant results.
Hirose H et al. · 2007
Researchers performed an in vitro study of low-level RF fields from IMT-2000 base stations to test if modulated signals cause hsp27 phosphorylation and overexpression. No significant differences in phosphorylated hsp27 at serine 82 or in hsp gene expression were found between exposed and sham-exposed groups.
Yan JG, Agresti M, Bruce T, Yan YH, Granlund A, Matloub HS. · 2007
Rats exposed to 6 hours of daily cellular phone emissions for 18 weeks exhibited a significantly higher incidence of sperm cell death than control group rats through chi-squared analysis. Abnormal clumping of sperm cells was present in exposed rats and absent in controls.
Peyman A, Holden SJ, Watts S, Perrott R, Gabriel C · 2007
The dielectric properties of pig cerebrospinal tissues were measured in vivo and in vitro in the frequency range of 50 MHz-20 GHz. White matter and spinal cord showed significant variation as a function of animal age while no age-related variations were recorded for grey matter. The in vitro study included tissue from pigs weighing approximately 10, 50, and 250 kg to examine variation with age. Total combined measurement uncertainty was calculated at each frequency point and reported over representative frequency regions. Comparisons were made between the in vivo and in vitro data and with literature from the past decade.
Panagopoulos DJ et al. · 2007
Researchers used Drosophila melanogaster reproductive capacity to compare the biological activity of GSM 900 MHz and DCS 1800 MHz radiation. Both radiation types significantly reduced reproductive capacity in a non-thermal manner. GSM 900 MHz radiation appeared more bioactive than DCS 1800 MHz, a difference attributed mostly to field intensity and less to carrier frequency.
Panagopoulos DJ, Chavdoula ED, Nezis IP, Margaritis LH · 2007
Researchers used the TUNEL assay to detect DNA fragmentation in early and mid-oogenesis stages of Drosophila melanogaster. Flies were exposed to GSM 900-MHz or DCS 1800-MHz radiation from a mobile phone for a few minutes daily over the first six days of adult life. Both radiation types induced DNA fragmentation in all cell types of the egg chamber, leading to degeneration of egg chambers. Germarium and stages 7-8 were the most sensitive developmental stages, with germarium even more sensitive than stages 7-8.
Lonappan A, Rajasekharan C, Thomas V, Bindu G, Mathew KT. · 2007
Researchers measured the dielectric properties of human colostrum and breast milk at microwave frequencies using a rectangular cavity perturbation technique at the S-band. Dielectric constants of the samples increased as weeks elapsed, attributed to reduced fat content and increased lactose concentration.
English NJ, Mooney DA. · 2007
Avdikos A et al. · 2007
The isolated leiomyosarcoma cells were cultured and exposed to a resonant low intensity radiofrequency EMF at frequencies between 10 kHz to 120 kHz for 45 minutes daily over two consecutive days. Three-month-old female Wistar rats were inoculated with leiomyosarcoma cells that had been exposed or not exposed to the EMF. Rats exposed to resonant EMF after tumor appearance (EG-I) showed tumor regression to 66% incidence and had longer survival and slower tumor growth than the other groups.
Guney M, Ozguner F, Oral B, Karahan N, Mungan T. · 2007
Rats were randomly assigned to four groups of eight each, including a control, a sham, a 900 MHz EMR exposure group, and an EMR plus vitamins E and C group, and the EMR groups received 30 minutes per day for 30 days. EMR exposure increased endometrial nitric oxide and malondialdehyde levels and decreased superoxide dismutase, catalase, and glutathione peroxidase activities, while combined vitamins E and C reversed these changes. The EMR group showed diffuse severe apoptosis in endometrial epithelial, glandular, and stromal cells and diffuse eosinophilic leucocyte and lymphocyte infiltration, which were significantly reduced by vitamins E and C.
Friedman J, Kraus S, Hauptman Y, Schiff Y, Seger R. · 2007
Elhag MA, Nabil GM, Attia AM. · 2007
Rats were divided into control, fractionated exposure (15 min/day for four days), and acute exposure groups. Plasma vitamin C decreased by 47% in fractionated group and 59.8% in acute group compared to controls. Vitamin E decreased by 33% and 65.8%, and vitamin A by 44.4% and 46.8% in fractionated and acute groups respectively. Reduced glutathione dropped by 19.8% and 35.3% in fractionated and acute groups. Catalase and superoxide dismutase activities decreased significantly, with acute group lower than fractionated group.
Calota V, Dragoiu S, Meghea A, Giurginca M. · 2007
The study evaluated the effects of 50 Hz magnetic fields at different intensities on chemiluminescence intensity of human serum. Exposure for 1 and 2 h increased chemiluminescence emission, and adding prooxidants FeCl(2) and H(2)O(2) in different concentrations increased chemiluminescence intensity even more.
Zhao TY, Zou SP, Knapp PE. · 2007
Researchers exposed primary cultured neurons and astrocytes to GSM cell phone emissions at 1900 MHz for 2 hours. Neurons showed up-regulation of caspase-2, caspase-6, and Asc genes in both 'on' and 'stand-by' modes. Astrocytes showed up-regulation of the same genes only in 'on' mode and also up-regulated the Bax gene.
Barcal J, Vozeh F · 2007
ECoG evaluation showed a distinct shift to lower frequency components in wild type mice but only gentle differences in Lurcher mutant mice. Hippocampal rhythmicity showed gentle changes with increase of higher frequencies and changes in theta oscillations in both healthy and mutant mice.
Wang KJ, Yao K, Lu DQ. · 2007
