Ahmed NA, Radwan NM, Aboul Ezz HS, Salama NA · 2017
Researchers exposed adult rats to EMR at a frequency of 900 MHz modulated at 217 Hz, with a power density of 0.02 mW/cm2 and SAR of 1.245 W/kg, and measured oxidative stress parameters in the hippocampus and striatum. EMR exposure produced disturbances in oxidant and antioxidant parameters in both brain regions. Green tea mega EGCG given at the beginning of EMR exposure for two and three months had more beneficial effect against EMR-induced oxidative stress than EGCG given after two months of exposure.
Zhang D, Zhang Y, Zhu B, Zhang H, Sun Y, Sun C · 2017
Researchers enrolled 186 male workers with occupational exposure to high-voltage electricity lines and 154 male subjects with insignificant exposure as a reference control. Resveratrol or placebo was given as dietary supplements at 500 mg twice daily, and inflammatory biomarkers and biomarkers of oxidative stress were assessed. Workers who had long-term exposure to high-voltage electricity lines showed elevated urinary levels of 8-OHdG and F2-isoprostane compared to the reference group. Resveratrol significantly reversed the adverse impacts of ELF-EMF, and stimulated cytokine production by resveratrol was found in exposed workers but not in the reference group.
Kamalipooya S et al. · 2017
Researchers studied the effects of combining a static magnetic field (SMF) with the anticancer drug cisplatin on oxidative stress in human cervical cancer cells (HeLa) and normal skin fibroblast cells (Hu02). Cells were exposed to SMF intensities of 7, 10, and 15 mT for 24 and 48 hours, and cytotoxic effects were measured using reactive oxygen species content and membrane lipid peroxidation. The combination of both treatments for 48 hours led to a marked decrease in HeLa cell viability of about 89% compared to untreated cells. The study suggests that among the optional intensities of SMF tested, the intensity of 10 mT led to higher damage to cancer cells at lower doses of the drug.
Höytö A, Herrala M, Luukkonen J, Juutilainen J, Naarala J. · 2017
Researchers exposed human SH-SY5Y neuroblastoma cells to a 50 Hz, 100 μT magnetic field with or without a non-phototoxic level of blue light for 24 hours. The magnetic field increased cytosolic superoxide production, while blue light suppressed that effect. Mitochondrial superoxide production was reduced by both the magnetic field and blue light, but these effects were not additive. Micronucleus frequency was not affected by blue light or the magnetic field alone, but blue light, significantly when combined with the magnetic field, enhanced menadione-induced micronuclei.
Giorgi G et al. · 2017
Researchers exposed human neural cells (BE(2)C) to an extremely low frequency pulsed magnetic field (50 Hz, 1 mT) for 24 and 48 hours, alone and combined with oxidative stress, to study DNA methylation changes. Exposure to the magnetic field alone or oxidative stress alone produced only weak changes in DNA methylation levels at different CpG sites. When the two exposures were combined, a significant decrease in DNA methylation levels was found at different CpG sites, and most of those changes were transient.
Falone S et al. · 2017
Researchers investigated whether a 50 Hz, 1 mT ELF magnetic field promoted hyperproliferation and improved defence against reactive oxygen species in SH-SY5Y human neuroblastoma cells. The field activated antioxidant and detoxification pathways linked to more aggressive cell behavior, along with upregulation of major sirtuins and increased NRF2 signaling. Exposure to a 50 Hz magnetic field as low as 100 µT may still be able to alter cancer cell behavior and responses to clinically relevant drugs.
Dornelles EB et al. · 2017
Researchers tested the in vitro cytotoxic effects of a 5 mT static magnetic field on human blood cells carrying different variants of the Val16Ala polymorphism in the manganese superoxide dismutase gene. Cytotoxic effects were observed in AA cells at all exposure times, while AV cells showed higher mortality only after 6 hours, and higher apoptosis induction was seen in AA cells compared to VV and AV cells. The authors suggest the results indicate a toxicogenetic effect of the static magnetic field related to an imbalance in SOD2 activity.
Djordjevic NZ, Paunović MG, Peulić AS · 2017
Researchers investigated whether short-term exposure to ELF-EMF at 50 Hz could produce anxiety-like behaviour in rats through changes in hypothalamic oxidative stress and nitric oxide. Ten adult male Wistar albino rats were divided into a control group with no exposure and an experimental group exposed to the field during 7 days, after which open field and elevated plus maze tests measured anxiety-like behaviour. The exposed rats showed anxiety-like behaviour and higher concentrations of superoxide anion and nitric oxide in the hypothalamus, while peroxynitrite concentration was not affected.
Cichoń N et al. · 2017
Patients were divided into two groups, both undergoing the same 4-week rehabilitation program, with one group also receiving daily ELF-EMF exposure. The ELF-EMF group was exposed to a field of 40 Hz and 7 mT for 15 minutes per day. ELF-EMF significantly increased 3-nitrotyrosine and nitrate/nitrite levels, while NOS2 expression was insignificantly decreased in both groups. The researchers concluded that ELF-EMF therapy is capable of promoting recovery in poststroke patients.
Calcabrini C et al. · 2017
Researchers investigated whether ELF-EMF exposure causes significant cell damage in human keratinocytes, to support potential ELF-EMF use in regenerative medicine for skin injuries. Reactive oxygen species production was evaluated in human keratinocytes exposed for 1 H to 50 Hz ELF-EMF at field strengths from 0.25 to 2 G, and significant ROS increases resulted at 0.5 and 1 G. All significant alterations observed in the first 4 H of exposure reverted to controls 24 H after, and the exposure did not have a cytotoxic effect.
Manville, A. · 2016
Choi Y-K, Urnukhsaikhan E, Yoon H-H, Seo Y-K, Park J-K · 2016
Unknown authors · 2016
The study randomized 867 workers with or without exposure to 110-420 kV power lines into green tea polyphenol or placebo groups. Urinary 8-isoprostane and 8-OHdG were measured to assess oxidative stress and DNA damage. Exposed workers had significantly higher levels of both markers, which decreased after 12 months of supplementation. The protective effect was lost three months after stopping supplementation.
Ohtani S et al. · 2016
Researchers exposed Sprague-Dawley rats to 2.14 GHz W-CDMA RF signals at whole-body averaged SAR of 4 W/kg and 0.4 W/kg. At 4 W/kg the core temperature rose about 1.5°C and plateaued for the remainder of the exposure. Heat-shock protein and transcription factor genes were significantly upregulated in the cerebral cortex and cerebellum after 6 hr/day exposure at 4 W/kg, but not after 3 hr/day. No significant changes in core temperature or gene expression occurred at 0.4 W/kg.
Hardell L et al · 2016
Researchers used an exposimeter to measure radiofrequency radiation across 20 bands from 88 to 5,850 MHz at Stockholm Central Railway Station. They recorded 1,669 data points and found a median total exposure of 921 μW/m2 with mean levels varying between 2,817 and 4,891 μW/m2 per walking round. High mean measurements were observed for GSM + UMTS 900 downlink and UMTS 2100 downlink, and almost all levels exceeded the BioInitiative precautionary target of 3–6 μW/m2.
Unknown authors · 2016
The comment was published in Cancer Epidemiology in October 2016 with an online date of August 2016. The author is Bandara from Castle Hill, NSW, Australia.
Sato Y, Kiyohara K, Kojimahara N, Yamaguchi N. · 2016
Lewis RC et al. · 2016
Researchers explored the relationship between mobile phone use patterns and semen quality markers in a longitudinal cohort of 153 men at a Boston fertility clinic. Mobile phone use duration, headset use, and phone carrying location were assessed via nurse-administered questionnaire. A total of 350 semen samples were collected and analyzed onsite. Linear mixed models with random intercepts accounted for multiple semen samples per man. Overall, there was no evidence for a relationship between mobile phone use and semen quality.
Leng L, Zhang Y. · 2016
Reale M et al. · 2016
Researchers exposed SH-SY5Y neuroblastoma cells to 50 Hz/1 mT ELF-EMF for short (1h-3h) and sub-chronic (48 h) periods. Exposed cells showed an increased intracellular 5-hydroxyindoleacetic acid/5-hydroxytryptamine ratio reflecting transmitter synthesis, catabolism, and release. Matrix metalloproteinases involved in neuronal cell death were not significantly altered. The balance between reactive oxygen species generation and elimination, and between pro- and anti-inflammatory cytokines, was maintained. The changes were minor compared to damage expected to underlie neurodegeneration or cognitive impairment.
Andrianome S et al. · 2016
Researchers compared melatonin levels in 30 individuals with IEI-EMF and 25 controls without electromagnetic exposure. The IEI-EMF group had significantly lower sleep scores than controls. Saliva melatonin and urine aMT6s levels did not differ between groups. Three questionnaires evaluated sleep quality and quantity, melatonin was quantified in saliva and its metabolite aMT6s in urine, and levels were compared by two-way ANOVA at various times.
Nakatani-Enomoto S et al. · 2016
Roser K, Schoeni A, Röösli M · 2016
The HERMES study sample consisted of 439 Swiss adolescents aged 12–17 years. Researchers assessed behavioral problems with the Strengths and Difficulties Questionnaire and concentration capacity with a standardized computerized cognitive test named FAKT. Cross-sectional analyses showed behavioral problems associated with self-reported wireless device use but not operator-recorded mobile phone use, while concentration capacity was associated with both self-reported and operator-recorded exposures. Longitudinal analyses found no consistent associations between RF-EMF exposure measures and either outcome. The authors suggest information bias and reverse causality likely explain the cross-sectional findings.
Redmayne M et al. · 2016
Researchers recruited 619 fourth-grade students aged 8 to 11 from 37 schools in Melbourne and Wollongong, Australia. Participants completed a questionnaire, a computerised cognitive test battery, and the Stroop colour-word test while parents reported the children's mobile and cordless phone call frequencies. Phone use was categorised by weekly call count into none, some (≤ median) or more (> median), with medians of 2.5 calls for mobile phones and 2.0 for cordless phones. Only 5 of 78 comparisons were statistically significant; higher mobile phone use was linked to slower reaction time on a response-inhibition task, and higher cordless phone use was linked to slower Stroop interference time and poorer accuracy on visual recognition, episodic memory, and identification tasks.
Calvente I et al. · 2016
