Kesari KK, Behari J. · 2009
Researchers investigated the effects of 50-GHz microwave radiation on the brain of Wistar rats. The animals were exposed for 2 hours a day for 45 days continuously at a power level of 0.86 μW/cm2. Exposed rats showed DNA double-strand breaks and a significant decrease in GPx and SOD activity in brain cells, while catalase activity showed a significant increase compared with control. PKC decreased significantly in the whole brain and hippocampus of the exposed group.
Gajski G, Garaj-Vrhovac V. · 2009
Researchers investigated whether bee venom could protect against DNA damage caused by 915-MHz microwave radiation in Wistar rat lymphocytes. Whole blood lymphocytes were treated with 1 μg/mL bee venom before irradiation, and comet assays were used to assess basal and oxidative DNA damage. Bee venom showed a decrease in DNA damage compared with irradiated samples, and was found to have a radioprotective effect against both basal and oxidative DNA damage.
Del Vecchio G et al. · 2009
Researchers studied the effects of radiofrequency electromagnetic field exposure on neuronal maturation using two in vitro models: murine SN56 cholinergic cells and rat primary cortical neurons. Cells were exposed at 1 W/kg at 900 MHz GSM modulated, and neurite emission, outgrowth, and branching were examined at multiple time points. RF-EMF exposure reduced the number of neurites in both cell systems, and this reduction correlated with increased expression of beta-thymosin mRNA.
Unknown authors · 2008
Researchers exposed male rats to a static magnetic field of 128 mT for one hour per day over five consecutive days. They tested emotional behavior in the elevated plus maze and open field, and learning and memory in the Morris water maze. Exposed rats showed no significant difference in anxiety tests but spent half as much time in the open arms of the plus maze, and they were partially impaired in both initial learning and one-week retention in the water maze.
Unknown authors · 2008
Researchers exposed groups of 108 DMBA-treated Fischer 344 rats to a 100 muT, 50 Hz magnetic field or sham exposure for 26 weeks. MF exposure significantly facilitated mammary tumorigenesis. The incidence of histologically verified adenocarcinomas was increased by 45% (P = 0.0095). The most pronounced effect on tumor incidence was seen in the cranial inguinal complexes.
Unknown authors · 2008
Researchers exposed 48 pregnant rats to two magnetic field patterns across four intensity ranges during prenatal development. Cytometric anomalies were significantly increased in hippocampal regions associated with adult neuronal neogenesis.
Unknown authors · 2008
Researchers exposed 30 adult female Sprague Dawley rats to extremely low frequency magnetic field for 4 hours per day over 7 days, with 15 rats serving as controls. The exposed rats had significantly lower goblet cell density than controls (p = 0.010). They also showed conjunctival edema and inflammation (p < 0.001 and p = 0.003), but no difference in fibroblast proliferation (p = 0.422).
Unknown authors · 2008
Unknown authors · 2008
Researchers used the SOD-1 mouse model to assess the possible effect of ELF magnetic fields on ALS development. Seven mice per group were exposed to 50 Hz magnetic fields at 100 and 1000 microT(rms) before clinical signs of ALS appeared. Exposure lasted 7 weeks while body weight, motor performance, and life span were monitored. The results showed no evidence of a link between ELF exposure and ALS in this transgenic animal model.
Unknown authors · 2008
Researchers used a rat model of chemically induced B acute lymphoblastic leukemia to test effects of 50 Hz magnetic fields with and without harmonics. The experiment included 280 rats and compared body weight, survival time, bone marrow blast cells, cumulative leukemia incidence, and leukemia type between exposed and unexposed groups. No significant differences were found for any parameter (p > 0.05). Results did not support the hypothesis that ELF-MFs, with or without harmonics, affect the development of B acute lymphoblastic leukemia in children.
Unknown authors · 2008
Exposure did not significantly affect body weight or testosterone levels. TUNEL staining revealed a significantly higher apoptotic rate in germ cells of exposed mice compared to sham controls, with TUNEL-positive cells mainly being spermatogonia. Electron microscopy showed degenerating spermatogonia with condensation of nuclear chromatin similar to apoptosis.
Unknown authors · 2008
Sanchez S et al. · 2008
Researchers investigated heat shock protein expression in hairless rat skin exposed to GSM-900 and GSM-1800 signals. They studied Hsc70, Hsp25, and Hsp70 using immunolabeling of epidermal skin slices. Single exposures were 2 hours at 0 and 5 W/kg; repeated exposures were 2 hours per day, 5 days per week for 12 weeks at 0, 2.5, and 5 W/kg. Neither single nor repeated exposures altered HSP expression regardless of GSM signal or SAR.
Prisco MG et al. · 2008
Lee JJ et al. · 2008
NIH3T3 mouse fibroblasts were exposed to 849 MHz RF radiation at average SAR values of 2 or 10 W/kg for either 1 hour or 1 hour per day for 3 days. Cellular invasion and migration were assessed using in vitro Matrigel invasion and Transwell migration assays. Cell cycle distribution was analyzed at 24 and 48 hours after exposure by flow cytometry. The study found no detectable effects on cell cycle distribution, cellular migration, or invasion at the tested SAR values.
Huang TQ et al. · 2008
Researchers exposed HEI-OC1 immortalized mouse auditory hair cells to 1763 MHz RF at 20 W/kg SAR in a CDMA chamber for 24 and 48 hours. They assessed cell cycle, DNA damage, heat shock protein expression, MAPK phosphorylation, and gene expression, finding no changes in cell cycle, DNA damage, HSP expression, or MAPK phosphorylation. Microarray analysis showed only 29 genes (0.09% of total) changed more than 1.5-fold after exposure.
Hirose H et al. · 2008
Researchers continuously exposed BALB/3T3 cells to 2.1425 GHz W-CDMA RF fields at SARs of 80 and 800 mW/kg for 6 weeks. They also tested MCA-treated cells and MCA plus TPA-treated cells for tumor promotion and co-promotion effects. No significant differences in transformation frequency were found between RF-exposed groups and sham-exposed controls in any treatment condition. The results suggest that exposure to low-level RF radiation of up to 800 mW/kg does not induce cell transformation.
Yilmaz F, Dasdag S, Akdag MZ, Kilinc N · 2008
Researchers investigated anti-apoptotic bcl-2 protein in rat brain and testes after whole-body exposure to 900 MHz cellular phone radiation. The results showed that 20 minutes of radiation did not alter bcl-2 protein in the brain and testes of rats. The study used two groups of eight Sprague-Dawley rats each, with the experimental group exposed to phones in speech condition for 20 minutes per day for one month and the sham group exposed to turned-off phones. The authors speculated that bcl-2 may not be involved in radiation effects on the brain and testes of rats.
Paparini A et al. · 2008
Mice were exposed to GSM 1800 MHz signal for 1 hour at a whole body SAR of 1.1 W/kg. Gene expression was measured in whole brain using microarrays with over 22,600 probe sets. Comparison of sham and exposed animals showed no significant difference in gene expression. With less stringent analysis, 75 genes appeared modulated but were not confirmed by real-time PCR.
Kim TH et al. · 2008
Researchers used a carousel-type chamber to expose the heads of C57BL mice to 849 MHz or 1763 MHz RF radiation. Mice were irradiated intermittently at 7.8 W/kg for up to 12 months. Brain tissues collected at 6 and 12 months showed no differences in histology, cell proliferation, NeuN and GFAP expression in hippocampus and cerebellum, or cell death between exposure and control groups. Body weights did not differ among sham, 849 MHz, and 1763 MHz groups during the study.
Grafström G et al. · 2008
Researchers exposed 32 rats to GSM-900 radiation once weekly for two hours over 55 weeks at average whole-body SAR values of 0.6 and 60 mW/kg. Sixteen rats were sham exposed and eight served as cage controls. After behavioral tests conducted 5–7 weeks after the last exposure, the brains were examined for albumin extravasation, dark neurons, lipofuscin aggregation, and neuronal cytoskeletal changes, but no significant alterations were detected.
Sinha RK · 2008
Researchers exposed male rats to 2450 MHz microwave radiation and assessed thyroid hormones and behavior. Exposed rats showed hyperactivity and aggression, with significant changes in open-field and elevated plus-maze tests. Thyroid hormone levels changed, with T3 decreasing and T4 increasing, correlating with behavioral changes.
Devrim E et al. · 2008
EMR exposure increased MDA, XO, and GSH-Px activities in erythrocytes compared with controls. In kidney tissue, EMR increased MDA and CAT activities but decreased XO and ADA activities. In heart tissue, EMR decreased MDA, ADA, and XO activities. Vitamin C seems to make partial protection against oxidative stress in erythrocytes.
Millenbaugh NJ et al. · 2008
Rats were exposed to 35 GHz millimeter waves at 75 mW/cm(2), 42 degrees C heat, or sham, with skin collected at 6 and 24 h for gene expression and at 3-6 h or 24-48 h for histopathology. Microscopic examination showed neutrophil aggregation in vessels, stromal cell degeneration, and collagen breakdown in the dermis of exposed rats. Changes were detected in 56 genes at 6 h and 58 genes at 24 h in millimeter-wave-exposed rats. Affected genes included those for transcription regulation, protein folding, oxidative stress, immune response, and tissue matrix turnover at both times, with more extracellular matrix and chemokine genes altered at 24 h. Real-time RT-PCR confirmed up-regulation of Hspa1a, Timp1, S100a9, Ccl2, and Angptl4 at 24 h.
Hruby R, Neubauer G, Kuster N, Frauscher M · 2008
The study aimed to detect whether long-term exposure to 902-MHz GSM-type wireless communication signals would affect DMBA-induced mammary tumours in female Sprague-Dawley rats. Five hundred female rats were each given a single oral dose of 17 mg DMBA per kg body weight at an age of 46-48 days.
