6,486 Studies Reviewed. 85.2% of Original Studies Found Biological Effects. The Evidence is Clear.

EMF Research Studies

Browse 6,486 peer-reviewed studies on electromagnetic field health effects from 4 research libraries.

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Wireless Phone Use and Risk of Adult Glioma: Evidence from a Meta-Analysis

Wang P et al · 2018

Researchers conducted a meta-analysis of ten studies on wireless phone use and adult glioma risk. The combined odds ratio for ever use of wireless phones was 1.03 (95% CI, 0.92-1.16) with high heterogeneity. No significant association was found for tumor location in the temporal lobe. A significant association was found for long-term users (≥10 years) with odds ratio 1.33 (95% CI, 1.05-1.67).

Occupational exposure to high-frequency electromagnetic fields and brain tumor risk in the INTEROCC study: An individualized assessment approach

Vila J et al · 2018

Researchers conducted a multinational population-based case-control study (INTEROCC) with nearly 4000 cases and over 5000 controls to examine occupational RF and IF-EMF exposure in relation to glioma and meningioma risk. Individual cumulative exposure indices for RF and IF-EMF were assigned using a source-exposure matrix and detailed interview data on work with or near EMF sources. About 10% of participants were exposed to RF and 1% to IF-EMF; no clear positive associations were found, though the highest recent RF magnetic field exposure yielded odds ratios of 1.62 for glioma and 1.52 for meningioma, with confidence intervals including 1.

Brain & Nervous SystemNo Effects Found

Impact of Long-Term RF-EMF on Oxidative Stress and Neuroinflammation in Aging Brains of C57BL/6 Mice.

Jeong YJ et al. · 2018

The aim of the study was to observe the impact of long-term RF-EMF on oxidative stress and neuroinflammation in aging brains of C57BL/6 mice. Compared with young mice, aged mice showed significantly increased protein and lipid oxidative damage markers in the brain. Aged mice also had significantly elevated markers of DNA damage, apoptosis, astrocytes, and microglia. Long-term RF-EMF exposure did not change the levels of oxidative stress, DNA damage, apoptosis, astrocyte, or microglia markers in aged mouse brains. Long-term RF-EMF exposure also did not alter locomotor activity in aged mice.

Brain & Nervous SystemNo Effects Found

50-Hz magnetic field impairs the expression of iron-related genes in the in vitro SOD1G93A model of amyotrophic lateral sclerosis.

Consales C et al. · 2018

The study used SH-SY5Y human neuroblastoma cells stably over-expressing wild-type, G93A, or H46R mutant SOD1. Cells were exposed to 50-Hz, 1 mT ELF-MF or sham control for up to 72 hours. Exposure caused no change in proliferation, viability, or reactive oxygen species, but significantly deregulated iron-related genes IRP1, MFRN1, and TfR1 only in SOD1G93A cells, with a slight difference in total iron content (p = .0512).

Association between mobile phone use and depressed mood in Japanese adolescents: a cross-sectional study.

Ikeda K, Nakamura K. · 2018

The cross-sectional study included 2,785 high school students in Niigata, Japan. Mean mobile phone use was 24 hours per week with a median of 18 hours. Longer mobile phone use was associated with female students, no sports club participation, early mobile phone use, and fewer hours of sleep. Overall associations between hours of mobile phone use and mood scores were significant for depressed mood, tension and excitement, and fatigue.

Transcranial static magnetic field stimulation (tSMS) of the visual cortex decreases experimental photophobia.

Lozano-Soto E et al. · 2018

In a sham-controlled double-blind crossover study, tSMS was applied for 10 minutes with a cylindrical magnet on the occiput of 20 healthy subjects. Researchers assessed subjective discomfort induced by low-intensity and high-intensity visual stimuli in a dark room before, during and after tSMS or sham. Compared to sham, tSMS significantly reduced the discomfort induced by high-intensity light stimuli.

Transcranial Static Magnetic Field Stimulation over the Primary Motor Cortex Induces Plastic Changes in Cortical Nociceptive Processing.

Kirimoto H et al. · 2018

Researchers applied transcranial static magnetic field stimulation or sham over the primary motor and somatosensory cortices in 18 healthy volunteers for 15 minutes. They recorded evoked potentials before, immediately after, and 10 minutes after stimulation. The evoked potential amplitude was significantly reduced immediately after stimulation over the primary motor cortex, but not after stimulation over the somatosensory cortex or sham.

Decrease of motor cortex excitability following exposure to a 20 Hz magnetic field as generated by a rotating permanent magnet.

Gallasch E, Rafolt D, Postruznik M, Fresnoza S, Christova M. · 2018

Fourteen healthy volunteers received 20 Hz tAMF stimulation over the motor cortex, over the vertex, and 20 Hz tACS over the motor cortex, each for 15 minutes. TMS assessments were performed before and after the interventions to evaluate changes in MEP, SICI, and ICF. After tAMF stimulation, MEP amplitudes and ICF decreased while the effect of SICI increased. After tACS stimulation, MEP amplitudes increased with no effects on SICI and ICF.

Low Frequency Stimulation Reverses the Kindling-Induced Impairment of Learning and Memory in the Rat Passive-avoidance Test.

Esmaeilpour K et al. · 2018

Hippocampal kindled rats showed deficits in learning and memory in the passive-avoidance test. Low-frequency stimulation reversed the impairment in learning and memory behavior in kindled rats. Low-frequency stimulation also diminished kindling-induced neuronal loss and atrophy in the hippocampus. The stimulation protocol used 200 monophasic square wave pulses of 0.1 ms duration at 1 Hz, delivered in four packages every five minutes.

Long-lasting effects of transcranial static magnetic field stimulation on motor cortex excitability.

Dileone M, Mordillo-Mateos L, Oliviero A, Foffani G. · 2018

The study comprised 5 experiments in 45 healthy subjects. 30-minute tSMS decreased motor evoked potential amplitude compared to sham for at least 30 minutes after stimulation ended. This long-lasting effect was associated with increased short-interval intracortical facilitation and reduced short-interval intracortical inhibition. 10-minute tSMS produced opposite changes in intracortical excitability, decreasing short-interval intracortical facilitation while increasing short-interval intracortical inhibition.

Extremely low frequency electromagnetic field reduces oxidative stress during the rehabilitation of post-acute stroke patients.

Cichoń N, Rzeźnicka P, Bijak M, Miller E, Miller S, Saluk J. · 2018

Researchers enrolled 57 post-stroke patients and assigned them to an ELF-EMF therapy group or a control group that received only kinesiotherapy. Oxidative stress was measured in plasma using thiobarbituric acid reactive substances (TBARS), thiol groups, and carbonyl groups. Rehabilitation progress was assessed with the Activities of Daily Living (ADL), Mini-Mental State Examination (MMSE), and Geriatric Depression Scale (GDS). All oxidative stress parameters were significantly reduced and clinical parameters significantly improved in the ELF-EMF group compared with the control group.

Increase in Blood Levels of Growth Factors Involved in the Neuroplasticity Process by Using an Extremely Low Frequency Electromagnetic Field in Post-stroke Patients.

Cichoń N et al. · 2018

The study aimed to evaluate the effect of extremely low-frequency electromagnetic field therapy on brain plasticity during stroke rehabilitation. Forty-eight patients were split into two groups receiving the same rehabilitation program, with the study group also receiving a standard series of 10 ELF-EMF treatments. ELF-EMF significantly increased growth factors and cytokines involved in neuroplasticity and promoted better functional recovery.

POSSIBLE IMPLEMENTATION OF GABAERGIC AND GLUTAMATERGIC SYSTEMS IN REALIZATION OF ANTIEPILEPTIC EFFECTS OF ACOUSTIC RANGE ELECTRO - MAGNETIC FIELDS.

Bukia N et al. · 2018

The study aimed to examine whether GABAergic and glutamatergic systems mediate the antiepileptic effects of acoustic-range electromagnetic fields. Exposure to the field decreased behavioral seizure activity in genetically epilepsy-prone rats that had been treated with GABA-A or GABA-B receptor antagonists. When a glutamate receptor agonist was given during field exposure, it provoked seizures, but the seizures were less severe than in rats not exposed to the field.

Measurement of the 100 MHz EMF radiation in vivo effects on zebrafish D. rerio embryonic development: A multidisciplinary study.

Piccinetti CC et al. · 2018

Researchers evaluated the biological effects of 100 MHz radiofrequency electromagnetic field exposure on zebrafish embryos using a multidisciplinary protocol. The 100 MHz EMF affected zebrafish embryonic development from 24 to 72 hours post-fertilization across all analyzed pathways. At 48 hours post-fertilization, reduced growth, increased oxidative stress gene transcription, apoptotic and autophagic processes, and modified cholesterol metabolism were detected. By 72 hours post-fertilization, embryos partially recovered from stress and reached hatching time comparable to controls.

Melatonin attenuates radiofrequency radiation (900 MHz)-induced oxidative stress, DNA damage and cell cycle arrest in germ cells of male Swiss albino mice.

Pandey N, Giri S. · 2018

Researchers exposed Swiss albino mice to RFR for 3 hours twice daily for 35 days and gave some mice melatonin at 5 mg/kg body weight per day. RFR-exposed mice showed extensive DNA damage, arrest in pre-meiotic spermatogenesis, low sperm count, and sperm head abnormalities. Biochemical assays revealed excess free radical generation and histological changes in testis and germ cells. Melatonin supplementation diminished or abolished these effects.

Radiofrequency radiation emitted from Wi-Fi (2.4 GHz) causes impaired insulin secretion and increased oxidative stress in rat pancreatic islets.

Masoumi A, Karbalaei N, Mortazavi SMJ, Shabani M. · 2018

The Wi-Fi exposure used a frequency of 2.45 GHz. The Wi-Fi exposed group had significantly lower weight gain than controls and developed hyperglycemia. Plasma insulin levels and glucose-stimulated insulin secretion from pancreatic islets were significantly reduced, while pancreatic lipid peroxidation increased and GSH, SOD, and GPx activities decreased.

Exposure to radiation from single or combined radio frequencies provokes macrophage dysfunction in the RAW 264.7 cell line.

López-Furelos A et al. · 2018

Researchers exposed RAW 264.7 macrophage cells to single or combined radiofrequency signals at 900 and 2450 MHz for 4, 24, 48, or 72 hours in a GTEM chamber. They measured cell viability, nitric oxide production, HSP70 and TNF-α expression, and phagocytic activity. Phagocytic activity declined with longer exposure, while combined exposure raised HSP70 at 48 hours and significantly increased nitric oxide and TNF-α at 72 hours.

A histopathological and biochemical evaluation of oxidative injury in the sciatic nerves of male rats exposed to a continuous 900-megahertz electromagnetic field throughout all periods of adolescence.

Kerimoğlu G, Güney C, Ersöz Ş, Odacı E. · 2018

Twenty-four male Sprague Dawley rats aged 21 days were divided into control, sham, and EMF groups, and the EMF group was exposed to a 900-MHz field for one hour each day from postnatal day 21 to 59. Histopathological examination showed normal Schwann cells and axons in all groups, but marked thickening of the epineurium in the EMF-exposed rats. Biochemical analysis found higher MDA, SOD, and CAT levels in the EMF group versus control and sham, and the apoptotic index was significantly increased in the EMF group.

Evidence of oxidative stress after continuous exposure to Wi-Fi radiation in rat model.

Kamali K, Taravati A, Sayyadi S, Gharib FZ, Maftoon H. · 2018

Researchers exposed male Wister rats to 2.45 GHz Wi-Fi radiation continuously for 10 weeks. Total antioxidant capacity of plasma and activities of CAT, GSH-Px, and SOD decreased significantly in exposed rats. GST activity increased significantly in the exposed group. GSH and TBARS levels did not change significantly after exposure.

Long term exposure to cell phone frequencies (900 and 1800 MHz) induces apoptosis, mitochondrial oxidative stress and TRPV1 channel activation in the hippocampus and dorsal root ganglion of rats.

Ertilav K, Uslusoy F, Ataizi S, Nazıroğlu M. · 2018

Twenty-four adult rats were divided into control, 900 MHz, and 1800 MHz exposure groups. Each experimental group was exposed to electromagnetic radiation for 60 minutes per day, five days per week, for one year. Both frequencies increased TRPV1 currents, calcium influx, reactive oxygen species, mitochondrial membrane depolarization, apoptosis, and caspase 3 and 9 activities in the hippocampus and dorsal root ganglion. The 1800 MHz exposure produced greater increases in these measures than the 900 MHz exposure.

Effect of low-level 1800 MHz radiofrequency radiation on the rat sciatic nerve and the protective role of paricalcitol.

Comelekoglu U et al. · 2018

Researchers divided rats into four groups: control, paricalcitol only, RF exposure only, and RF plus paricalcitol. Rats in the RF groups were exposed to 1,800 MHz RF radiation for 1 hour per day for 4 weeks. RF exposure caused significant reduction in nerve signal amplitude, prolonged latency, increased malondialdehyde levels, increased catalase activity, and degeneration of myelinated nerve fibers. Paricalcitol administration partially ameliorated these neuropathic changes.

Exposure to mobile phone (900-1800 MHz) during pregnancy: tissue oxidative stress after childbirth

Bahreyni Toossi MH et al. · 2018

Pregnant Balb/C mice were exposed to mobile phone radiation (900–1800 MHz) for 2 hours per day over 20 days during pregnancy. Researchers measured malondialdehyde, total thiol groups, superoxide dismutase, and catalase in heart, liver, kidney, cerebellum, and hippocampus tissues of dams and offspring. MDA levels were significantly increased while TTG, SOD, and CAT were significantly decreased in the tissues of both dams and offspring.

Alternating magnetic field enhances cytotoxicity of Compound C

Akimoto T et al. · 2018

An AMF at 280 kHz and 250 Arms for 30 minutes significantly enhanced Compound C cytotoxicity and promoted apoptosis in human GB cell lines. The AMF also increased Compound C-induced cell-cycle arrest at the G2 phase and inhibited cell proliferation. The AMF increased Compound C-induced reactive oxygen species production. The AMF decreased ERK phosphorylation and suppressed protective autophagy induced by Compound C.

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