6,486 Studies Reviewed. 85.2% of Original Studies Found Biological Effects. The Evidence is Clear.
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Brain & Nervous System

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Key Finding: 83% of 1,950 primary studies on brain & nervous system found biological effects from EMF exposure.

Of 1,950 studies examining brain & nervous system, 83% found measurable biological effects from EMF exposure.

Lowest Documented Effect

Research found effects on brain & nervous system at exposures as low as:

Study Exposure Level in ContextStudy Exposure Level in Context4.3 × 10⁻⁵ mGExtreme Concern - 5 mGFCC Limit - 2,000 mGEffects documented below the Building Biology "No Concern" threshold (0.2 mG)FCC limit is 46.5 million times higher than this level

Research Overview

  • -When you review the peer-reviewed literature on electromagnetic field exposure and brain function, the numbers tell a compelling story: 84% of the 2,753 studies examining this relationship have documented measurable effects.
  • -This isn't a fringe concern or preliminary finding.
  • -This is the dominant scientific picture, and it deserves your attention.

When you review the peer-reviewed literature on electromagnetic field exposure and brain function, the numbers tell a compelling story: 84% of the 2,753 studies examining this relationship have documented measurable effects. This isn't a fringe concern or preliminary finding. This is the dominant scientific picture, and it deserves your attention. The documented effects span multiple systems within your nervous system.

Of 2,753 studies examining EMF effects on the brain and nervous system, approximately 84 percent found measurable biological effects.

The scientific evidence demonstrates that radiofrequency electromagnetic fields from mobile phones and wireless devices produce measurable effects on nervous system function and cellular processes in the brain.

Source: BioInitiative Working Group. BioInitiative Report: A Rationale for Biologically-based Public Exposure Standards for Electromagnetic Radiation. Edited by Cindy Sage and David O. Carpenter, BioInitiative, 2012, updated 2020. www.bioinitiative.org

Research Statistics by EMF Type

EMF TypeStudiesShowing EffectsPercentage
ELF22920891.00%
RF30522272.00%

Source: Dr. Henry Lai research database

Showing 2,030 studies

Affective response to 5 microT ELF magnetic field-induced physiological changes.

Stevens P · 2007

Researchers studied whether exposure to a 0–5 µT magnetic field at EEG alpha-band frequencies (8–12 Hz) would affect emotional state. Participants reported a change in emotional state following exposure, and a decrease in global field power was observed. The frontal alpha-asymmetry that would physiologically indicate a directly induced emotional state was absent, and researchers suggested that participant experiences were due to an interpretation of the effects of MF exposure.

Exposure to extremely low frequency magnetic fields enhances locomotor activity via activation of dopamine D1-like receptors in mice.

Shin EJ et al. · 2007

Researchers examined the role of dopaminergic receptors in behavioral changes induced by extremely low frequency magnetic fields (ELF-MF). Exposure to ELF-MF at 2.4 mT for 1 hour per day, for one or seven days, enhanced locomotor activity in a time-dependent manner. The results suggest that ELF-MF-induced behavioral responses are, at least in part, mediated by activation of dopamine D1-like receptors.

Influence of extremely low frequency magnetic fields on Ca2+ signaling and NMDA receptor functions in rat hippocampus

Manikonda PK et al. · 2007

Researchers exposed rats to 50 Hz magnetic fields at 50 and 100 μT intensities for 90 days and then examined hippocampal tissue. Compared to controls, ELF exposure was associated with increased intracellular calcium levels and changes in the activity of several calcium-related enzymes. Binding to NMDA receptors was also found to be decreased in exposed rats. The researchers suggested that perturbed neuronal functions caused by ELF exposure may involve altered calcium signaling contributing to aberrant NMDA receptor activities.

Acute exposure to a 50 Hz magnetic field impairs consolidation of spatial memory in rats

Jadidi M et al. · 2007

Researchers used a water maze to evaluate how magnetic field exposure affects consolidation and retrieval of spatial memory in rats. Exposure to a 50 Hz, 8 mT magnetic field for 20 minutes immediately after training impaired retention performance, but exposure at 2 mT did not. Exposure given shortly before retention testing had no effect on performance.

Fifty Hertz electromagnetic field exposure stimulates secretion of β-amyloid peptide in cultured human neuroglioma

Del Giudice E et al. · 2007

Researchers tested whether low-frequency electromagnetic field exposure could affect amyloidogenic processes in cultured cells. They exposed H4 neuroglioma cells that stably overexpress human mutant amyloid precursor protein to a 3.1 mT 50 Hz field. Overnight exposure significantly increased secretion of amyloid-beta peptide, including the isoform Aβ 1–42, without affecting cell survival.

Pulsed radio-frequency electromagnetic fields: dose-dependent effects on sleep, the sleep EEG and cognitive performance.

Regel SJ et al. · 2007

Researchers exposed the heads of 15 healthy male subjects for 30 min prior to sleep to a pulse-modulated EMF signal at different intensities or a sham condition, in a double-blind, crossover design. The active exposure levels used peak spatial specific absorption rates of 0.2 W kg–1 and 5 W kg–1. Sleep EEG analysis showed a dose-dependent increase of power in the spindle frequency range in non-REM sleep, while sleep architecture was not affected. Reaction speed slowed with increasing field intensity in the 1-back task, but accuracy in the CRT and N-back tasks was not affected in a dose-dependent manner.

Effects of GSM 1800 MHz on dendritic development of cultured hippocampal neurons.

Ning W, Xu SJ, Chiang H, Xu ZP, Zhou SY, Yang W, Luo JH · 2007

Researchers cultured hippocampal neurons from rats and exposed them to GSM 1800 MHz microwaves at either 2.4 or 0.8 W/kg for 15 minutes each day from DIV6 to DIV14. At 2.4 W/kg, the density and mobility of dendritic filopodia at DIV8 and the density of mature spines at DIV14 were significantly decreased, and the average length of dendrites per neuron at DIV10 and DIV14 was also decreased. Dendritic arborization was unaltered in the exposed neurons, and no significant changes were found in neurons exposed to 0.8 W/kg.

Mobile phone radiation and the developing brain: behavioral and morphological effects in juvenile rats.

Kumlin T et al. · 2007

Researchers exposed young male Wistar rats to a 900 MHz mobile phone signal for 2 h/day on 5 days/week. After 5 weeks of exposure at whole-body average specific energy absorption rates of 0.3 or 3.0 W/kg or sham exposure, rats were assessed for behavioral and morphological changes. No degenerative changes, dying neurons, or effects on blood-brain barrier leakage were detected, and no group differences appeared in the open-field, plus maze, or acoustic startle response tests. In the water maze test, significantly improved learning and memory were detected in rats exposed to RF fields.

Mobile phone 'talk-mode' signal delays EEG-determined sleep onset.

Hung CS, Anderson C, Horne JA, McEvoy P · 2007

Researchers exposed 10 healthy young adults to talk, listen, standby, or sham signal modes for 30 minutes, then gave them a 90-minute sleep opportunity. Sleep latency after talk mode was markedly and significantly delayed beyond listen and sham modes. This condition effect was also evident in 1–4 Hz EEG frontal power, a frequency range described as particularly sensitive to sleep onset. There was no condition effect for subjective sleepiness.

Effect of an acute 900 MHz GSM exposure on glia in the rat brain: A time-dependent study

Brillaud E, Piotrowski A, de Seze R · 2007

Researchers measured GFAP expression in rat brains 2, 3, 6, and 10 days after a single 15-minute 900 MHz GSM exposure at a brain averaged SAR of 6 W/kg. A statistically significant increase in GFAP stained surface area was observed 2 days after exposure in the frontal cortex and the caudate putamen. A smaller statistically significant increase was noted 3 days after exposure in those same areas and in the cerebellum cortex. The researchers concluded this was a temporary effect, probably due to a hypertrophy of glial cells, and noted that whether the effect could be harmful remains to be studied.

Studying gene expression profile of rat neuron exposed to 1800MHz radiofrequency electromagnetic fields with cDNA microassay.

Zhao R, Zhang S, Xu Z, Ju L, Lu D, Yao G. · 2007

Researchers investigated whether 1800 MHz radiofrequency electromagnetic fields could influence gene expression in rat neurons. Among 1200 candidate genes, 24 were up-regulated and 10 were down-regulated after 24 hours of intermittent exposure at a SAR of 2 W/kg. The researchers concluded that gene expression in rat neurons could be altered by exposure to radiofrequency electromagnetic fields under their experimental conditions.

Radiofrequency radiation (900 MHz) induces Egr-1 gene expression and affects cell-cycle control in human neuroblastoma cells.

Buttiglione M et al. · 2007

Researchers exposed human neuroblastoma SH-SY5Y cells to 900 MHz radiofrequency radiation at 1 W/kg to study effects on gene expression and cell-cycle control. Short-term exposures produced a transient increase in Egr-1 mRNA levels along with activation of the MAPK subtypes ERK1/2 and SAPK/JNK. Exposure had an anti-proliferative effect, and a significant G2-M cell-cycle arrest was observed, with signs of apoptosis appearing after 24 hours. A significant decrease in mRNA levels of Bcl-2 and survivin genes, both linked to signaling between G2-M arrest and apoptosis, was also observed.

Sex and estrous cycle differences in the behavioral effects of high-strength static magnetic fields: role of ovarian steroids

Unknown authors · 2006

Rats were given 10-min access to a novel saccharin solution and then restrained within a 14-T magnet for 30 min. In experiment 1, males were compared with females across the estrous cycle after a single MF exposure. Females circled more and acquired a more persistent CTA than males; circling was highest on the day of estrus. In experiment 2, the effects of three MF exposures were compared among intact rats, ovariectomized females, and ovariectomized females with steroid replacement. Compared with intact rats, ovariectomy increased circling; estrogen replacement blocked the increase, and males acquired a stronger initial CTA but extinguished faster than intact or ovariectomized females.

Stimulation of ubiquitin-proteasome pathway through the expression of amidohydrolase for N-terminal asparagine (Ntan1) in cultured rat hippocampal neurons exposed to static magnetism

Unknown authors · 2006

Researchers screened genes responsive to brief magnetism in cultured rat hippocampal neurons using differential display analysis. They identified Ntan1 as a magnetism-responsive gene in rat brain. Northern blot analysis showed that Ntan1 mRNA increased about three-fold after 3 hours in response to brief magnetism. Brief magnetism induced degradation of MAP2 without affecting cell morphology or viability, and this degradation was prevented by a selective inhibitor of the 26S proteasome. Overexpression of Ntan1 using a recombinant adenovirus vector decreased MAP2 protein expression in hippocampal neurons.

Electrohypersensitivity: state-of-the-art of a functional impairment

Unknown authors · 2006

The aim of the studies was to investigate possible alterations in the cellular and neuronal systems of electrohypersensitive persons' skin. Age- and sex-matched persons without symptoms served as controls. Immunohistochemistry with antisera to previously characterized marker substances was used. Preliminary data indicate various alterations in the skin of electrohypersensitive persons.

A potential multiple resonance mechanism by which weak magnetic fields affect molecules and medical problems: the example of melatonin and experimental "multiple sclerosis"

Unknown authors · 2006

The hypothesis predicts optimal ameliorating effects on experimental allergic encephalomyelitis at derived intensities of about 35 and 70 nT and a frequency of 7 Hz. These predictions were congruent with prior rat experiments using magnetic field strengths of about 1-5000 nT at 0.5, 7, 40, or 60 Hz. The model proposes that weaker fields in the nanoTesla to picoTesla range would optimally affect micromolar melatonin concentrations and that mitochondrial proton gradients may be critical. The model offers an alternative explanation to variations of Faraday's Law and the Boltzmann constant that have been used to dismiss biological effects from weak magnetic fields.

Growth assessment of children exposed to low frequency electromagnetic fields at the Abu Sultan area in Ismailia (Egypt)

Unknown authors · 2006

Researchers conducted a cross-sectional study of 780 children aged 0-12 years in two areas of Ismailia, Egypt. The exposed group comprised 390 children living within 50 meters of high voltage power lines, and the control group comprised 390 children from another area. Standard anthropometric measurements and hand X-rays for bone maturation were performed. Exposed children showed significantly reduced head and chest circumferences and height at all ages, and a significant delay in carpal bone ossification.

Can EMF exposure during development leave an imprint later in life?

Unknown authors · 2006

Initial reports indicated that exposure of chicken eggs during embryonic development to power-line electric fields of 50 and 60 Hz at 10 V/m in air could cause the brain tissues of the hatched chickens to respond differently in a particular test. More recently, an anecdotal report of human sensitivity to EMF has appeared that shows a health-related influence of prior exposure history to particular power-line frequencies in chemically sensitized individuals. These reports open the question of whether the ambient electromagnetic environment can leave an imprint on developing organisms and if such imprint changes have the potential for health consequences.

Learn More

For a comprehensive exploration of EMF health effects including brain & nervous system, along with practical protection strategies, explore these books by R Blank and Dr. Martin Blank.

FAQs: EMF & Brain & Nervous System

When you review the peer-reviewed literature on electromagnetic field exposure and brain function, the numbers tell a compelling story: 84% of the 2,753 studies examining this relationship have documented measurable effects. This isn't a fringe concern or preliminary finding. This is the dominant scientific picture, and it deserves your attention. The documented effects span multiple systems within your nervous system.
The SYB Research Database includes 1,950 peer-reviewed studies examining the relationship between electromagnetic field exposure and brain & nervous system. These studies have been conducted by researchers worldwide and published in scientific journals. The research spans multiple decades and includes various types of EMF sources including cell phones, WiFi, power lines, and other common sources of electromagnetic radiation.
83% of the 1,950 studies examining brain & nervous system found measurable biological effects from EMF exposure. This means that 1621 studies documented observable changes in biological systems when exposed to electromagnetic fields. The remaining 17% either found no significant effects or had inconclusive results, which is typical in scientific research where study design and exposure parameters vary.