3,138 Studies Reviewed. 77.4% Found Biological Effects. The Evidence is Clear.
Research Guide

5G vs 4G Radiation: What's Different?

Based on 653 peer-reviewed studies

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People often ask whether 5G is more dangerous than 4G. This question requires understanding how 5G technology differs from previous generations and what research exists on each.

5G networks operate across multiple frequency bands. Low-band 5G (600-900 MHz) is actually similar to 4G frequencies. Mid-band 5G (2.5-4 GHz) overlaps with existing WiFi. High-band 5G (24-40+ GHz, "millimeter wave") represents the newest frequencies for consumer wireless exposure.

This page compares what research shows about radiation exposure from 5G versus 4G technologies.

Key Research Findings

  • 5G uses multiple frequency bands with different characteristics
  • Millimeter waves (high-band 5G) penetrate less deeply into tissue
  • More cell towers can actually reduce individual exposure levels

Related Studies (653)

Effects of exposure to electromagnetic field (1.8/0.9 GHz) on testicular function and structure in growing rats.

Ozlem Nisbet H, Nisbet C, Akar A, Cevik M, Karayigit MO · 2012

Turkish researchers exposed young male rats to cell phone frequencies (900 MHz and 1800 MHz) for 2 hours daily over 90 days to study effects on reproductive development. They found that EMF exposure increased testosterone levels and accelerated sperm development compared to unexposed rats. The researchers concluded this electromagnetic exposure may trigger early puberty in developing males.

Melatonin modulates wireless (2.45 GHz)-induced oxidative injury through TRPM2 and voltage gated Ca(2+) channels in brain and dorsal root ganglion in rat.

Nazıroğlu M et al. · 2012

Researchers exposed rats to 2.45 GHz wireless radiation (the same frequency used by WiFi and microwave ovens) for one hour daily over 30 days, finding it caused brain damage including increased calcium influx into neurons, oxidative stress, and abnormal brain wave activity. When rats were given melatonin supplements along with the radiation exposure, these harmful effects were significantly reduced, suggesting melatonin may protect against wireless radiation damage to the nervous system.

2.45-Gz wireless devices induce oxidative stress and proliferation through cytosolic Ca²⁺ influx in human leukemia cancer cells.

Nazıroğlu M, Ciğ B, Doğan S, Uğuz AC, Dilek S, Faouzi D. · 2012

Researchers exposed human leukemia cancer cells to 2.45 GHz radiation (the same frequency used by WiFi and microwaves) for periods ranging from 1 to 24 hours. They found that this radiation caused cancer cells to multiply more rapidly and triggered harmful oxidative stress by allowing excess calcium to flood into the cells. The longer the exposure, the more pronounced these effects became.

Reproductive Health100 citations

Evidence for mobile phone radiation exposure effects on reproductive pattern of male rats: Role of ROS.

Kesari KK, Behari J. · 2012

Researchers exposed male rats to mobile phone radiation for 2 hours daily over 45 days and found significant damage to their reproductive health. The exposed rats had lower testosterone levels, damaged sperm structure, and produced fewer offspring that weighed less than normal. The scientists believe this damage occurs because the radiation triggers harmful reactive oxygen species (free radicals) that attack reproductive cells.

Effect of exposure to radio frequency radiation emitted by cell phone on the developing dorsal root ganglion of chick embryo: a light microscopic study.

Ingole IV, Ghosh SK. · 2012

Researchers exposed developing chick embryos to cell phone radiation and examined the effects on nerve cells in the spinal cord area (dorsal root ganglion neurons). They found that exposure caused dose-dependent damage to these developing nerve cells, meaning higher doses caused more damage. The damage persisted even when researchers gave the embryos breaks between exposures, suggesting the effects weren't easily reversed.

Effects of radiofrequency radiation on human ferritin: an in vitro enzymun assay.

Fattahi-Asl J et al. · 2012

Researchers exposed human blood serum samples to cell phone radiation at 900 MHz for 30 minutes and found that ferritin levels (a protein that stores iron in the body) decreased significantly compared to unexposed samples. The exposed samples showed ferritin levels drop from 87.25 to 84.94 micrograms per liter, a statistically significant 2.6% reduction. This suggests that cell phone radiation may interfere with iron storage proteins in blood, potentially affecting how our bodies manage iron metabolism.

Effect of 900 MHz radio frequency radiation on beta amyloid protein, protein carbonyl, and malondialdehyde in the brain.

Dasdag S, Akdag MZ, Kizil G, Kizil M, Cakir DU, Yokus B. · 2012

Turkish researchers exposed rats to 900 MHz radiofrequency radiation (the same frequency used by many cell phones) for 2 hours daily over 10 months to study brain effects. They found significant increases in protein carbonyl, a marker of protein damage, along with elevated levels of beta amyloid protein and malondialdehyde in the exposed rats' brains. These findings suggest that long-term cell phone radiation exposure may damage brain proteins, which could have implications for neurological health.

Protective effects of β-glucan against oxidative injury induced by 2.45-GHz electromagnetic radiation in the skin tissue of rats.

Ceyhan AM et al. · 2012

Researchers exposed rats to WiFi-frequency radiation (2.45 GHz) for one hour daily over four weeks and measured damage to skin tissue. The radiation significantly increased oxidative stress markers and decreased protective antioxidant enzymes in the skin. However, when rats were given beta-glucan (a natural compound found in oats and mushrooms) before each exposure, it largely prevented this cellular damage.

Single-strand DNA breaks in human hair root cells exposed to mobile phone radiation.

Cam ST, Seyhan N. · 2012

Researchers collected hair samples from eight people before and after they used a mobile phone for 15 and 30 minutes, then tested for DNA damage in the hair root cells. They found that just 15 minutes of phone use caused significant DNA breaks in cells near the ear, with even more damage after 30 minutes. This suggests that everyday mobile phone use can damage DNA in nearby tissues within minutes of exposure.

Electromagnetic fields instantaneously modulate nitric oxide signaling in challenged biological systems.

Pilla AA. · 2012

Researchers exposed cells to pulsed radiofrequency electromagnetic fields and found they immediately triggered a nearly 3-fold increase in nitric oxide production within seconds. Nitric oxide is a crucial signaling molecule that helps regulate blood flow, immune responses, and healing processes in the body. This study provides the first real-time evidence that non-thermal EMF exposure can rapidly alter this important cellular signaling pathway.

Induction of an adaptive response in human blood lymphocytes exposed to radiofrequencyfields: influence of the universal mobile telecommunication system (UMTS) signal and the specific absorption rate.

Zeni O et al. · 2012

Researchers exposed human immune cells (lymphocytes) to 3G cell phone radiation at various power levels for 20 hours, then treated them with a DNA-damaging chemical. They discovered that cells pre-exposed to radiation at 0.3 watts per kilogram showed less genetic damage than unexposed cells, suggesting the radiation triggered protective mechanisms. This adaptive response indicates that low-level radiofrequency exposure may prime cells to better defend against subsequent toxic challenges.

Exposure to 2.45 GHz electromagnetic fields elicits an HSP-related stress response in rat hippocampus.

Yang XS, He GL, Hao YT, Xiao Y, Chen CH, Zhang GB, Yu ZP. · 2012

Researchers exposed rats to 2.45 GHz electromagnetic fields (the same frequency as WiFi and microwave ovens) and found that their brain cells produced stress proteins in response. The hippocampus, a brain region crucial for memory and learning, showed increased levels of heat shock proteins (HSP27 and HSP70), which cells produce when they're under stress. This provides direct biological evidence that EMF exposure triggers a stress response in brain tissue.

A 1.8-GHz radiofrequency radiation induces EGF receptor clustering and phosphorylation in cultured human amniotic (FL) cells. Int J Radiat Biol. 88(3):239-244, 2012.

Sun W, Shen X, Lu D, Fu Y, Lu D, Chiang H · 2012

Cell phone radiation (1.8 GHz) activated growth receptors in human cells after just 15 minutes of exposure. The effects occurred at radiation levels of 0.5 W/kg and higher but not at 0.1 W/kg, showing radiofrequency radiation can directly trigger cellular responses that control cell growth and communication.

Effects of external electromagnetic fields on the conformational sampling of a short alanine peptide.

Solomentsev GY, English NJ, Mooney DA · 2012

Researchers used computer simulations to study how 2.45 GHz microwave radiation (the same frequency used in WiFi and microwave ovens) affects protein structure at the molecular level. They found that electromagnetic fields disrupted the normal folding patterns of proteins by interfering with hydrogen bonds that keep proteins stable. This suggests that microwave radiation can alter fundamental biological processes by changing how proteins maintain their shape and function.

Electromagnetic fields at 2.45 GHz trigger changes in heat shock proteins 90 and 70 without altering apoptotic activity in rat thyroid gland.

Misa Agustiño MJ et al. · 2012

Researchers exposed rats to WiFi-frequency radiation (2.45 GHz) for 30 minutes and found it triggered cellular stress responses in thyroid tissue. Heat shock proteins dropped significantly within 90 minutes, though recovered by 24 hours, demonstrating that brief microwave exposure can disrupt normal thyroid cell function.

Calcium-binding proteins and GFAP immunoreactivity alterations in murine hippocampus after 1 month of exposure to 835MHz radiofrequency at SAR values of 1.6 and 4.0W/kg.

Maskey D, Kim HJ, Kim HG, Kim MJ · 2012

Researchers exposed mice to cell phone frequency radiation (835 MHz) for one month at power levels similar to heavy phone use. They found significant damage to brain cells in the hippocampus, including loss of protective calcium-binding proteins and signs of brain injury that worsened at higher exposure levels. This suggests that prolonged radiofrequency exposure may harm critical brain regions involved in memory and learning.

Pathophysiology of microwave radiation: effect on rat brain.

Kesari KK, Kumar S, Behari J. · 2012

Researchers exposed young rats to 2.45 GHz microwave radiation (the same frequency used in WiFi and microwaves) for 2 hours daily over 45 days at power levels similar to many consumer devices. The exposed rats showed decreased melatonin production and increased markers of brain cell damage and death. This suggests that chronic exposure to common microwave frequencies may harm brain tissue and disrupt sleep-regulating hormones.

The genotoxic effect of radiofrequency waves on mouse brain.

Karaca E et al. · 2012

Researchers exposed mouse brain cells to radiofrequency radiation at 10.7 GHz (similar to cell phone frequencies) and found dramatic genetic damage. The radiation caused an 11-fold increase in micronuclei formation, which indicates DNA breaks and chromosomal damage, while also altering genes involved in cell death and survival. This laboratory study demonstrates that RF radiation at levels comparable to cell phone exposure can directly damage brain cell DNA.

The toxic effects of mobile phone radiofrequency (940MHz) on the structure of calf thymus DNA.

Hekmat A, Saboury AA, Moosavi-Movahedi AA. · 2012

Researchers exposed DNA samples to mobile phone radiation (940 MHz) and found that the radiation caused permanent structural changes to the DNA molecules. The DNA became less stable, changed shape, and showed signs of damage that persisted even two hours after exposure ended. This suggests that radiofrequency radiation from mobile phones can directly alter DNA structure at the molecular level.

Further Reading

For a comprehensive exploration of EMF health effects and practical protection strategies, explore these books by R Blank and Dr. Martin Blank.