3,138 Studies Reviewed. 77.4% Found Biological Effects. The Evidence is Clear.
Research Guide

5G vs 4G Radiation: What's Different?

Based on 653 peer-reviewed studies

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People often ask whether 5G is more dangerous than 4G. This question requires understanding how 5G technology differs from previous generations and what research exists on each.

5G networks operate across multiple frequency bands. Low-band 5G (600-900 MHz) is actually similar to 4G frequencies. Mid-band 5G (2.5-4 GHz) overlaps with existing WiFi. High-band 5G (24-40+ GHz, "millimeter wave") represents the newest frequencies for consumer wireless exposure.

This page compares what research shows about radiation exposure from 5G versus 4G technologies.

Key Research Findings

  • 5G uses multiple frequency bands with different characteristics
  • Millimeter waves (high-band 5G) penetrate less deeply into tissue
  • More cell towers can actually reduce individual exposure levels

Related Studies (653)

The effect of radiofrequency radiation on DNA and lipid damage in female and male infant rabbits.

Güler G et al. · 2012

Researchers exposed infant rabbits to cell phone-type radiation (1800 MHz) either before birth, after birth, or both, then measured cellular damage in their livers. They found that this radiation increased both DNA damage and lipid damage (cellular breakdown) in the young animals. The study suggests that developing organisms may be particularly vulnerable to radiofrequency radiation from wireless devices.

Electromagnetic fields instantaneously modulate nitric oxide signaling in challenged biological systems.

Pilla AA · 2012

Researchers exposed brain cells to radiofrequency electromagnetic fields at 27.12 MHz and found the fields instantly triggered a nearly 3-fold increase in nitric oxide production. Nitric oxide is a crucial signaling molecule that helps regulate blood flow, immune responses, and healing processes in the body. The study shows that EMF exposure can immediately alter fundamental cellular communication pathways.

Exposure to 2.45 GHz electromagnetic fields elicits an HSP-related stress response in rat hippocampus.

Yang XS, He GL, Hao YT, Xiao Y, Chen CH, Zhang GB, Yu ZP. · 2012

Researchers exposed rats to WiFi-frequency radiation (2.45 GHz) for 20 minutes and found it triggered stress responses in brain cells. The radiation caused neurons in the hippocampus to produce heat shock proteins, indicating cellular damage in the brain region responsible for memory and learning.

Melatonin modulates wireless (2.45 GHz)-induced oxidative injury through TRPM2 and voltage gated Ca(2+) channels in brain and dorsal root ganglion in rat.

Nazıroğlu M et al. · 2012

Researchers exposed rats to 2.45 GHz radiation (the same frequency used in WiFi and microwave ovens) for one hour daily over 30 days and found it caused brain damage including increased calcium levels in neurons, oxidative stress, and abnormal brain wave patterns. However, when rats were given melatonin supplements, these harmful effects were significantly reduced, suggesting melatonin may protect against WiFi radiation damage to the brain and nervous system.

Calcium-binding proteins and GFAP immunoreactivity alterations in murine hippocampus after 1 month of exposure to 835 MHz radiofrequency at SAR values of 1.6 and 4.0 W/kg

Maskey D, Kim HJ, Kim HG, Kim MJ. · 2012

Researchers exposed mice to cell phone-level radiofrequency radiation (835 MHz) for one month at power levels similar to what phones emit during calls. They found significant damage to brain cells in the hippocampus, the brain region critical for memory and learning, including loss of protective proteins and signs of brain injury that worsened at higher exposure levels.

The genotoxic effect of radiofrequency waves on mouse brain.

Karaca E et al. · 2012

Turkish researchers exposed mouse brain cells to radiofrequency radiation at 10.715 GHz (similar to cell phone frequencies) for 6 hours daily over 3 days. They found an 11-fold increase in DNA damage markers and significant changes in gene expression related to cell death. This suggests that RF radiation at levels comparable to wireless devices can directly damage brain cell DNA and disrupt normal cellular functions.

Using model organism Saccharomyces cerevisiae to evaluate the effects of ELF-MF and RF-EMF exposure on global gene expression.

Chen G, Lu D, Chiang H, Leszczynski D, Xu Z · 2012

Researchers exposed yeast cells to both 50 Hz magnetic fields and 1800 MHz radiofrequency radiation to see if electromagnetic fields could change gene activity. They found that magnetic fields caused no confirmed gene changes, while radiofrequency exposure affected only 2-5 genes out of thousands tested. This suggests that EMF effects on basic cellular processes may be more limited than some studies indicate.

Using model organism Saccharomyces cerevisiae to evaluate the effects of ELF-MF and RF-EMF exposure on global gene expression.

Chen G, Lu D, Chiang H, Leszczynski D, Xu Z. · 2012

Researchers exposed yeast cells to power line magnetic fields and cell phone radiation for six hours to study genetic changes. Magnetic fields caused no confirmed gene alterations, while cell phone radiation changed only two genes out of thousands tested, suggesting minimal genetic impact.

DNA & Genetic DamageNo Effects Found

Analysis of gene expression in a human-derived glial cell line exposed to 2.45 GHz continuous radiofrequency electromagnetic fields.

Sakurai T et al. · 2011

Japanese researchers exposed human brain cells (glial cells) to 2.45 GHz radiofrequency radiation at various power levels for up to 24 hours and examined whether this changed gene activity. Using advanced genetic analysis techniques, they found no significant changes in how genes were expressed in the exposed cells compared to unexposed controls. This suggests that RF radiation at these levels did not trigger detectable genetic responses in this type of brain cell.

DNA & Genetic DamageNo Effects Found

Aneuploidy studies in human cells exposed in vitro to GSM-900 MHz radiofrequency radiation using FISH.

Bourthoumieu S et al. · 2011

Researchers exposed human cells to GSM-900 MHz cell phone radiation for 24 hours at various power levels to see if it caused aneuploidy (abnormal chromosome numbers that can lead to genetic disorders). They found no significant changes in chromosome structure even at the highest exposure level of 4 W/kg. This suggests that cell phone radiation at these levels does not cause this particular type of genetic damage in laboratory conditions.

DNA & Genetic DamageNo Effects Found

Analysis of gene expression in a human-derived glial cell line exposed to 2.45 GHz continuous radiofrequency electromagnetic fields

Sakurai T et al. · 2011

Researchers exposed human brain cells (glial cells) to 2.45 GHz radiofrequency radiation at power levels up to 10 times higher than current safety limits for up to 24 hours. They used advanced genetic analysis to look for changes in how genes were expressed, but found no significant alterations. This suggests that even at high exposure levels, this type of RF radiation may not directly damage the genetic machinery of brain cells.

.Effects of cell phone radiofrequency signal exposure on brain glucose metabolism.

Volkow ND et al. · 2011

Researchers used brain scans to measure glucose metabolism (brain activity) in 47 healthy people while they had cell phones placed against their ears for 50 minutes. They found significantly increased brain activity in the area closest to the phone's antenna compared to when the phones were turned off. The clinical significance of this brain activity change is unknown.

In vitro effects of radiofrequency electromagnetic waves on bovine spermatozoa motility.

Lukac N et al. · 2011

Researchers exposed bull sperm to 1800 MHz radiofrequency radiation (the same frequency used by GSM cell phones) for different time periods and measured sperm movement using computer analysis. They found that longer exposure times significantly reduced sperm motility and swimming ability, with the most dramatic effects occurring after 7 hours of exposure. This suggests that radiofrequency radiation can impair sperm function in a time-dependent manner.

The effects of single and repeated exposure to 2.45 GHz radiofrequency fields on c-Fos protein expression in the paraventricular nucleus of rat hypothalamus.

Jorge-Mora T et al. · 2011

Spanish researchers exposed rats to 2.45 GHz microwave radiation (the same frequency as WiFi and microwave ovens) and measured brain activity in a region called the hypothalamus that controls stress responses. They found that both single and repeated exposures triggered significant increases in cellular activation markers, with repeated exposure causing more than double the brain activity compared to unexposed animals. The effects occurred at power levels that didn't heat tissue, suggesting the brain responds to microwave radiation through non-thermal mechanisms.

Mutagenic and morphologic impacts of 1.8GHz radiofrequency radiation on human peripheral blood lymphocytes (hPBLs) and possible protective role of pre-treatment with Ginkgo biloba (EGb 761).

Esmekaya MA et al. · 2011

Turkish researchers exposed human blood cells to 1.8GHz cell phone radiation for up to 48 hours and found significant genetic damage, including broken chromosomes and destroyed cell structures. However, when cells were pre-treated with Ginkgo biloba extract, much of this damage was prevented. The study suggests that cell phone radiation can harm our DNA, but natural antioxidants might offer some protection.

Changes in Paramecium caudatum (protozoa) near a switched-on GSM telephone.

Cammaerts MC, Debeir O, Cammaerts R. · 2011

Belgian researchers exposed single-celled organisms called Paramecium to radiation from an active GSM cell phone (900 MHz frequency) and observed significant changes in their behavior and cellular structure. The exposed organisms moved more slowly and erratically, became physically broader, and showed signs of cellular membrane damage including problems with basic cellular functions like waste removal and movement. This suggests that cell phone radiation's primary target may be the protective membrane that surrounds all living cells.

Testicular apoptosis and histopathological changes induced by a 2.45 GHz electromagnetic field.

Saygin M, Caliskan S, Karahan N, Koyu A, Gumral N, Uguz A · 2011

Researchers exposed male rats to WiFi-frequency radiation (2.45 GHz) for one hour daily over 28 days and found significant damage to sperm-producing cells in the testicles. The radiation reduced the number of hormone-producing Leydig cells, impaired sperm production quality, and triggered programmed cell death (apoptosis) in testicular tissue. This suggests that common wireless frequencies could potentially affect male fertility through cellular damage in reproductive organs.

Induction of adaptive response in human blood lymphocytes exposed to 900 MHz radiofrequency fields: influence of cell cycle.

Sannino A et al. · 2011

Researchers exposed human immune cells (lymphocytes) to cell phone radiation at 1.25 W/kg for 20 hours, then tested how well the cells could protect themselves against a cancer-causing chemical. They found that cells exposed during their DNA-copying phase developed better defenses, while cells exposed during resting phases did not. This suggests that cell phone radiation may trigger protective responses in immune cells, but only when cells are actively dividing.

Local exposure of the rat cortex to radiofrequency electromagnetic fields increases local cerebral blood flow along with temperature.

Masuda H et al. · 2011

Japanese researchers exposed rat brain tissue to 2-GHz radiofrequency radiation at various intensities and measured changes in blood flow and temperature. They found that RF exposure significantly increased both local brain blood flow and temperature in a dose-dependent manner - the higher the exposure, the greater the response. This demonstrates that RF radiation directly affects brain physiology by triggering the body's natural response to increased heat in brain tissue.

Mutagenic and morphologic impacts of 1.8GHz radiofrequency radiation on human peripheral blood lymphocytes (hPBLs) and possible protective role of pre-treatment with Ginkgo biloba (EGb 761)

Esmekaya MA et al. · 2011

Researchers exposed human immune cells to 1.8GHz cell phone radiation for up to 48 hours and found significant DNA damage and cellular destruction that worsened over time. Ginkgo biloba extract provided some protection, suggesting certain antioxidants might help reduce radiation-induced genetic damage in immune cells.

Reproductive Health111 citations

The effect of pulsed 900-MHz GSM mobile phone radiation on the acrosome reaction, head morphometry and zona binding of human spermatozoa.

Falzone N, Huyser C, Becker P, Leszczynski D, Franken DR. · 2011

Researchers exposed healthy human sperm to cell phone radiation (900 MHz) for one hour at levels similar to what phones emit during calls. They found the radiation significantly reduced sperm head size by about 50% and decreased the sperm's ability to bind to eggs by nearly 30%. These changes could impair male fertility by making it harder for sperm to successfully fertilize an egg.

Induction of adaptive response: pre-exposure of mice to 900 MHz radiofrequency fields reduces hematopoietic damage caused by subsequent exposure to ionising radiation.

Cao Y, Xu Q, Jin ZD, Zhou Z, Nie JH, Tong J. · 2011

Chinese researchers found that mice exposed to cell phone radiation (900 MHz) for two weeks before receiving potentially lethal gamma radiation survived longer and showed less blood tissue damage. This suggests low-level radiofrequency exposure may activate protective cellular responses against subsequent radiation harm.

Further Reading

For a comprehensive exploration of EMF health effects and practical protection strategies, explore these books by R Blank and Dr. Martin Blank.