3,138 Studies Reviewed. 77.4% Found Biological Effects. The Evidence is Clear.
Research Guide

5G vs 4G Radiation: What's Different?

Based on 653 peer-reviewed studies

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People often ask whether 5G is more dangerous than 4G. This question requires understanding how 5G technology differs from previous generations and what research exists on each.

5G networks operate across multiple frequency bands. Low-band 5G (600-900 MHz) is actually similar to 4G frequencies. Mid-band 5G (2.5-4 GHz) overlaps with existing WiFi. High-band 5G (24-40+ GHz, "millimeter wave") represents the newest frequencies for consumer wireless exposure.

This page compares what research shows about radiation exposure from 5G versus 4G technologies.

Key Research Findings

  • 5G uses multiple frequency bands with different characteristics
  • Millimeter waves (high-band 5G) penetrate less deeply into tissue
  • More cell towers can actually reduce individual exposure levels

Related Studies (653)

GSM 900 MHz cellular phone radiation can either stimulate or depress early embryogenesis in Japanese quails depending on the duration of exposure.

Tsybulin O et al. · 2013

Researchers exposed developing quail embryos to cell phone radiation at extremely low power levels (1000 times weaker than typical phone exposure) and found dramatically different effects depending on exposure duration. Short exposure (38 hours) actually stimulated development and reduced DNA damage, while longer exposure (158 hours) stunted development and increased DNA damage. This reveals that EMF effects aren't simply dose-dependent but follow complex biological patterns.

Superposition of an incoherent magnetic field inhibited EGF receptor clustering and phosphorylation induced by a 1.8 GHz pulse-modulated radiofrequency radiation.

Sun W, Shen X, Lu D, Lu D, Chiang H · 2013

Researchers exposed human cells to 1.8 GHz radiofrequency radiation (similar to cell phone signals) and found it triggered abnormal clustering and activation of cellular receptors that control cell growth. Interestingly, when they added a weak 'noise' magnetic field alongside the RF exposure, it completely blocked these cellular changes at moderate power levels, suggesting the magnetic field provided some protection against RF-induced cellular disruption.

In-vitro exposure of neuronal networks to the GSM-1800 signal.

Moretti D et al. · 2013

French researchers exposed lab-grown brain cell networks to cell phone radiation (GSM-1800) for 3 minutes and measured their electrical activity in real time. They found that the radiation caused a 30% decrease in the brain cells' firing rate and bursting patterns - essentially making the neurons less active. The effect was reversible, meaning the cells returned to normal activity after exposure ended.

Induction of adaptive response in mice exposed to 900 MHz radiofrequency fields: Application of micronucleus assay

Jiang B, Zong C, Zhao H, Ji Y, Tong J, Cao Y · 2013

Researchers exposed mice to 900MHz radiofrequency radiation (similar to cell phone signals) for 4 hours daily over 7 days, then subjected them to high-dose gamma radiation. The mice pre-exposed to RF showed significantly less genetic damage from the gamma radiation compared to mice that received only gamma radiation. This suggests that low-level RF exposure may trigger protective cellular responses that help defend against more harmful radiation damage.

Overproduction of free radical species in embryonal cells exposed to low intensity radiofrequency radiation.

Burlaka A et al. · 2013

Researchers exposed developing quail embryos to extremely low-level cell phone radiation (900 MHz GSM) at power levels 4,000 times weaker than current safety limits. The exposure caused persistent overproduction of harmful free radicals and direct DNA damage in the developing embryos. The study demonstrates that even very weak radiofrequency radiation can trigger oxidative stress and genetic damage during critical developmental periods.

50 Hz Electromagnetic Field Produced Changes in FTIR Spectroscopy Associated with Mitochondrial Transmembrane Potential Reduction in Neuronal-Like SH-SY5Y Cells.

Calabrò E et al. · 2013

Italian researchers exposed human brain cells to 50 Hz magnetic fields (European power frequency) and found exposures above 0.8 milliTesla damaged cellular energy systems and altered protein structures. This demonstrates measurable biological harm from power-frequency magnetic fields at levels found in some occupational environments.

Oxidative and genotoxic effects of 900 MHz electromagnetic fields in the earthworm Eisenia fetida.

Tkalec M, Stambuk A, Srut M, Malarić K, Klobučar GI. · 2013

Croatian researchers exposed earthworms to 900 MHz cell phone radiation for 2-4 hours and found significant DNA damage at all tested levels, even the lowest exposure of 10 V/m. The radiation also triggered oxidative stress (cellular damage from harmful molecules) and damaged proteins and fats in the worms' cells. Importantly, modulated signals like those used by cell phones caused even more DNA damage than continuous radiation.

Overproduction of free radical species in embryonal cells exposed to low intensity radiofrequency radiation

Burlaka A et al. · 2013

Researchers exposed Japanese quail embryos to extremely low-power cell phone radiation (900 MHz) for over 150 hours and found it caused a persistent overproduction of harmful free radicals in developing cells. The radiation also damaged DNA and overwhelmed the embryos' natural antioxidant defenses. This cellular damage could potentially lead to cancer-causing changes in cells.

Electromagnetic fields induce neural differentiation of human bone marrow derived mesenchymal stem cells via ROS mediated EGFR activation.

Park JE, Seo YK, Yoon HH, Kim CW, Park JK, Jeon S · 2013

Researchers exposed human bone marrow stem cells to 50 Hz magnetic fields (the same frequency as power lines) at 1 milliTesla for several days. They found that this EMF exposure triggered the stem cells to transform into nerve cells by activating specific cellular pathways and generating reactive oxygen species (ROS). This suggests that power-frequency magnetic fields can directly influence how our stem cells develop and differentiate.

Influence of extremely low-frequency magnetic field on the activity of antioxidant enzymes during skin wound healing in rats

Glinka M, Sieroń A, Birkner E, Cieślar G · 2013

Researchers exposed rats with skin wounds to 40 Hz magnetic fields at 10 mT (millitesla) to see if it would help healing. They found the magnetic field exposure increased antioxidant enzyme activity and reduced cellular damage markers, suggesting the treatment helped protect cells from harmful oxidative stress during the wound healing process.

Effects of low intensity static magnetic field on FTIR spectra and ROS production in SH-SY5Y neuronal-like cells.

Calabrò E et al. · 2013

Italian researchers exposed human brain cells to a static magnetic field at 2.2 millitesla (below current safety limits) for 24 hours and found significant cellular damage. The magnetic field reduced the cells' energy production by 30%, increased harmful reactive oxygen species, and altered the structure of cellular proteins and fats. This demonstrates that even magnetic fields considered 'safe' by regulatory standards can disrupt normal brain cell function.

Effects of ELF Magnetic Field in Combination with Iron(III) Chloride (FeCl3) on Cellular Growth and Surface Morphology of Escherichia coli (E. coli)

Esmekaya MA et al. · 2013

Scientists exposed E. coli bacteria to power line frequency magnetic fields for 24 hours. While the bacteria survived and reproduced normally, the electromagnetic exposure damaged their cell surfaces, creating holes and destroying outer membranes. This shows EMF can cause cellular damage even when organisms appear healthy.

50 Hz Electromagnetic Field Produced Changes in FTIR Spectroscopy Associated with Mitochondrial Transmembrane Potential Reduction in Neuronal-Like SH-SY5Y Cells.

Calabrò E et al. · 2013

Researchers exposed brain cells to 50 Hz magnetic fields (household electricity frequency) at different strengths. Higher exposures damaged cell membrane proteins and reduced energy production in mitochondria, leading to decreased cell survival and suggesting power-frequency fields harm basic cellular functions.

Spatial memory and learning performance and its relationship to protein synthesis of Swiss albino mice exposed to 10 GHz microwaves

Sharma A, Sisodia R, Bhatnagar D, Saxena VK · 2013

Researchers exposed mice to 10 GHz microwave radiation for two hours daily over 30 days, then tested their memory using a water maze. Exposed mice took significantly longer to learn and remember locations, with reduced brain protein levels, suggesting microwave exposure may impair learning and memory.

In-vitro exposure of neuronal networks to the GSM-1800 signal.

Moretti D et al. · 2013

French researchers exposed lab-grown brain cells to cell phone radiation at 1800 MHz (the frequency used by GSM cell phones) for just 3 minutes. They found that the radiation caused a 30% decrease in the neurons' electrical activity - essentially making the brain cells less active. This effect was reversible, meaning the neurons returned to normal activity levels after the exposure ended.

DNA & Genetic DamageNo Effects Found

Effect of mobile phones on micronucleus frequency in human exfoliated oral mucosal cells.

Ros-Llor I et al. · 2012

Researchers examined DNA damage in mouth cells from 50 mobile phone users by comparing cells from the side of the face where they held their phone versus the opposite side. They found no differences in genetic damage markers (called micronuclei) between the phone side and non-phone side, regardless of how long people had been using mobile phones. This suggests that typical mobile phone use may not cause detectable DNA damage in oral tissues.

Oxidative StressNo Effects Found

Biological indicators in response to radiofrequency/microwave exposure

Marjanović AM, Pavičić I, Trošić I · 2012

This Croatian research team reviewed the current scientific understanding of how radiofrequency and microwave radiation (from devices like cell phones and WiFi) might affect living cells. They focused on reactive oxygen species (ROS) - molecules that can damage cells when produced in excess - as a potential mechanism for non-thermal biological effects. The paper calls for more laboratory research to better understand these mechanisms and support public health risk assessment.

Immune SystemNo Effects Found

Prenatal exposure to radiofrequencies: Effects of WiFi signals on thymocyte development and peripheral T cell compartment in an animal model.

Laudisi F et al. · 2012

Italian researchers exposed pregnant mice to WiFi signals (2.45 GHz) at high levels for 2 hours daily throughout pregnancy to study effects on their offspring's immune system development. They found no detrimental effects on T cell development, immune cell counts, or immune function in the offspring at either 5 weeks or 26 weeks of age. This suggests that prenatal WiFi exposure may not harm developing immune systems, though the study used exposure levels much higher than typical human exposure.

DNA & Genetic DamageNo Effects Found

Study of p53 expression and post-transcriptional modifications after GSM-900 radiofrequency exposure of human amniotic cells.

Bourthoumieu S et al. · 2012

Researchers exposed human embryonic cells to cell phone radiation (GSM-900 MHz) for 24 hours at various intensities to see if it would activate p53, a crucial protein that helps protect cells from DNA damage and cancer. The study found no significant changes in p53 expression or activation at any exposure level tested, including levels up to 4 W/kg. This suggests that GSM cell phone radiation may not trigger this particular cellular stress response in embryonic cells.

Oxidative StressNo Effects Found

Effects of 837 and 1950 MHz radiofrequency radiation exposure alone or combined on oxidative stress in MCF10A cells.

Hong MN et al. · 2012

Researchers exposed human breast tissue cells to cell phone frequencies (837 MHz and 1950 MHz) at high power levels for 2 hours to test whether radiofrequency radiation causes oxidative stress, a type of cellular damage linked to disease. The study found no signs of oxidative stress in the cells, even when exposed to both frequencies simultaneously. This suggests that under these specific laboratory conditions, RF radiation did not trigger the cellular damage processes that scientists look for as early warning signs of health effects.

Cancer & TumorsNo Effects Found

Combined effects of 60 Hz electromagnetic field exposure with various stress factors on cellular transformation in NIH3T3 cells.

Lee HJ, Jin YB, Lee JS, Choi JI, Lee JW, Myung SH, Lee YS. · 2012

Researchers exposed mouse cells to 60 Hz magnetic fields (the type from power lines) to see if this could trigger cellular transformation into cancer-like cells. They tested the magnetic field alone and combined with known cancer-causing agents like radiation. The study found no evidence that the magnetic field exposure caused cell transformation or enhanced the cancer-causing effects of other agents.

Differentiation of osteoprogenitor cells is induced by high-frequency pulsed electromagnetic fields.

Teven CM et al. · 2012

University of Chicago researchers exposed bone-forming stem cells to high-frequency electromagnetic fields at 27.1 MHz using an FDA-approved device called ActiPatch. They found that this exposure significantly increased the cells' ability to form bone tissue, triggering multiple markers of bone development without affecting cell growth rates. This suggests electromagnetic field therapy could potentially help repair bone defects in patients who lack sufficient natural bone tissue for reconstruction.

Further Reading

For a comprehensive exploration of EMF health effects and practical protection strategies, explore these books by R Blank and Dr. Martin Blank.