Unknown authors · 2008
Since 1999, multiple studies used high-throughput screening to examine genome-wide and proteome-wide responses to RF fields similar to mobile phones. The review concluded that results are still inconclusive because most positive reports have methodological flaws. No precise, reproducible response pattern was identified when positive findings were reported. HTST studies tend to exclude a cell stressor role for RF fields at nonthermal intensities.
Unknown authors · 2008
Researchers exposed murine L929 fibroblasts to 872 MHz continuous wave or pulse modulated RF radiation at 5 W/kg. They measured ornithine decarboxylase activity after 1- and 24-hour exposures, proliferation during 48 hours after 24-hour exposure, and caspase-3 activity after 1-hour exposure. The cells responded to fresh medium and serum deprivation, but no consistent effects of RF radiation were found. One statistically significant difference in ODC activity (p=0.03) was observed but considered a chance finding due to multiple comparisons and lack of support from other data. The results did not support effects on the endpoints studied, and stressed or stimulated cells were not more sensitive than normal cells to RF radiation.
Unknown authors · 2008
The paper reviews cytogenetic biomonitoring studies of humans exposed to radiofrequency radiation. Most reviewed studies report increased frequencies of genetic damage such as chromosomal aberrations in lymphocytes or buccal cells of exposed individuals. Radiation dosimetry was lacking in all papers, and some investigations had more severe flaws.
Unknown authors · 2008
The paper reviews epidemiological literature on mobile phone use and head and neck tumours to consolidate various reports. The literature is particularly heterogeneous, making it difficult to pool in a meta-analysis. Individual reports have described associations between mobile phone use and tumours, but the research is not consistent and on balance shows no evidence of an association. Small associations were reported for ipsilateral mobile phone use greater than 10 years for acoustic neuroma and glioma. The authors argue these associations are especially prone to confounding by recall bias and need replication with methods that minimise bias before being treated as more than suggestive.
Valbonesi P et al. · 2008
Researchers used the human trophoblast cell line HTR-8/SVneo to evaluate HSP70 and HSC70 protein and gene expression and primary DNA damage after nonthermal exposure to pulse-modulated 1817 MHz GSM-217 Hz waves for one hour at a SAR of 2 W/kg. Heat shock significantly enhanced HSP70 expression but not HSC70 expression. Exposure to high-frequency EMFs did not change HSP70 or HSC70 protein or gene expression. Hydrogen peroxide caused a significant increase in DNA strand breaks, but EMF exposure did not. Overall, no evidence was found that the exposure induced a HSP70-mediated stress response or primary DNA damage.
Tokola K, Kurttio P, Salminen T, Auvinen A. · 2008
Researchers assessed the validity of self-reported mobile phone use and developed a statistical model to account for over-reporting of exposure. They collected data from 70 volunteers using self-report interviews and network operator records. A correlation coefficient of 0.71 was found between self-reported and network operator data on average calling time. A simple linear regression model fitted the data reasonably well with an adjusted R² of 0.51.
Sanchez S et al. · 2008
Researchers investigated heat shock protein expression in hairless rat skin exposed to GSM-900 and GSM-1800 signals. They studied Hsc70, Hsp25, and Hsp70 using immunolabeling of epidermal skin slices. Single exposures were 2 hours at 0 and 5 W/kg; repeated exposures were 2 hours per day, 5 days per week for 12 weeks at 0, 2.5, and 5 W/kg. Neither single nor repeated exposures altered HSP expression regardless of GSM signal or SAR.
Sadetzki S et al. · 2008
Researchers conducted a nationwide study in Israel to assess the association between cellular phone use and parotid gland tumors. For all participants, regular cellular phone use was not associated with an increased risk of parotid gland tumors. However, heavy ipsilateral use without hands-free devices showed elevated odds ratios for cumulative calls and call time.
Prisco MG et al. · 2008
Nieto-Hernandez R et al. · 2008
Sixty-nine participants who reported sensitivity to mobile phones took part in a double-blind, placebo-controlled provocation study. Perceived sensitivity was measured with the Sensitive Soma Assessment Scale and symptom severity was recorded. Participants were then given feedback on the overall negative findings and their individual results. Fifty-eight participants completed a 6-month follow-up and no significant differences in SSAS or symptom severity scores were found between those told they were correct or incorrect. The authors concluded that accurate feedback was insufficient to change attributions or reduce symptoms.
Moisescu MG, Leveque P, Bertrand JR, Kovacs E, Mir LM · 2008
Researchers designed a device for continuous microscopic observation of cells exposed to modulated EMF similar to mobile phone signals. The system allowed follow-up of cell progression into mitosis under controlled temperature and CO2 environment. Cells exposed to 900 MHz modulated EMF for 1 hour at 30 degrees C and 2.2 W/kg showed increased endocytosis rate but no alteration in mitosis progression or duration. The exposure system was validated by cell endocytosis measurements.
Lerchl A et al. · 2008
Researchers exposed adult male Djungarian hamsters to RF-EMF at 383, 900, and 1800 MHz for 60 days at 80 mW/kg. Pineal and serum melatonin levels and organ weights were not affected in any experiment. Body weight increased transiently up to 4% at 383 MHz, increased up to 6% non-transiently at 900 MHz, and was unchanged at 1800 MHz.
Lee JJ et al. · 2008
NIH3T3 mouse fibroblasts were exposed to 849 MHz RF radiation at average SAR values of 2 or 10 W/kg for either 1 hour or 1 hour per day for 3 days. Cellular invasion and migration were assessed using in vitro Matrigel invasion and Transwell migration assays. Cell cycle distribution was analyzed at 24 and 48 hours after exposure by flow cytometry. The study found no detectable effects on cell cycle distribution, cellular migration, or invasion at the tested SAR values.
Lahkola A et al. · 2008
Researchers conducted an international case-control study of 1209 meningioma cases and 3299 population-based controls, identifying cases from hospitals and controls from national registers and general practitioners' lists. Detailed mobile phone use history was obtained by personal interview, assessing regular use (at least once a week for six months), duration, cumulative hours, and number of calls. Regular users showed lower meningioma risk (OR 0.76, 95% CI 0.65-0.89), with no increased risk related to years since first use, lifetime years, cumulative hours, or cumulative calls, and findings were consistent across network types, age, and sex.
Kim DW, Lee JH, Ji HC, Kim SC, Nam KC, Cha EJ. · 2008
Researchers exposed 18 self-declared EHS volunteers and 19 controls to both sham and real RF from a CDMA phone for half an hour each. They measured heart rate, respiration rate, and heart rate variability. The CDMA phone exposure produced no effects on any of these parameters in either group.
Johansson A et al. · 2008
Fifteen subjects with atopic dermatitis and 15 matched controls were exposed for 30 min to a 900 MHz GSM mobile phone-like RF field at 1 W/kg. Blood samples were taken before and after exposure to measure serum levels of substance P (SP), TNF R1, and brain derived neurotrophic factor (BDNF). At baseline, the atopic dermatitis group had significantly higher serum TNF R1 and significantly lower BDNF than controls, while SP did not differ. No effects of RF exposure were found on any of the measured substances. Symptom reports were too few to evaluate a possible correlation with exposure.
Huang TQ et al. · 2008
Researchers exposed HEI-OC1 immortalized mouse auditory hair cells to 1763 MHz RF at 20 W/kg SAR in a CDMA chamber for 24 and 48 hours. They assessed cell cycle, DNA damage, heat shock protein expression, MAPK phosphorylation, and gene expression, finding no changes in cell cycle, DNA damage, HSP expression, or MAPK phosphorylation. Microarray analysis showed only 29 genes (0.09% of total) changed more than 1.5-fold after exposure.
Huang TQ, Lee MS, Oh E, Zhang BT, Seo JS, Park WY. · 2008
They assessed cell proliferation, cell cycle progression, DNA damage, and gene expression. RF exposure did not significantly change cell numbers, cell cycle distribution, or DNA damage levels. Genome-wide analysis found no genes changed more than two-fold, but ten genes changed 1.3- to 1.8-fold, including down-regulation of CXCR3 and IL1R2.
Hirose H et al. · 2008
Researchers continuously exposed BALB/3T3 cells to 2.1425 GHz W-CDMA RF fields at SARs of 80 and 800 mW/kg for 6 weeks. They also tested MCA-treated cells and MCA plus TPA-treated cells for tumor promotion and co-promotion effects. No significant differences in transformation frequency were found between RF-exposed groups and sham-exposed controls in any treatment condition. The results suggest that exposure to low-level RF radiation of up to 800 mW/kg does not induce cell transformation.
Franzellitti S, Valbonesi P, Contin A, Biondi C, Fabbri E. · 2008
Researchers evaluated HSP70 gene and protein expression in human trophoblast HTR-8/SVneo cells after 4 to 24 hours of exposure to 1.8 GHz continuous-wave and GSM signals. Inducible HSP70 protein expression was not modified by any exposure condition. HSP70C transcript levels increased after 24 hours of GSM-217Hz exposure and decreased after 4 and 16 hours of GSM-Talk exposure, while HSP70A, HSP70B, and HSC70 transcripts did not change.
Falzone N et al. · 2008
Researchers exposed ejaculated, density-purified human spermatozoa to pulsed 900 MHz GSM radiation at SAR levels of 2.0 and 5.7 W/kg and compared them with controls over time. Mitochondrial membrane potential was measured by flow cytometry and showed no effect from the radiation. Sperm motility was assessed by computer-assisted sperm analysis, and all kinematic parameters were unaffected at 2.0 W/kg. At 5.7 W/kg, straight-line velocity and beat-cross frequency were significantly impaired over time (P < 0.05), with no exposure-by-time interaction. The authors state the result should not be ascribed to thermal effects due to cooling methods and temperature control.
Djeridane Y, Touitou Y, de Seze R. · 2008
Researchers exposed 20 healthy men to 900 MHz GSM radiation from a cellular phone for 2 hours per day, 5 days per week, for 4 weeks. Blood samples were taken hourly at night and every 3 hours during the day across four sessions spaced 15 days apart, using each man's pre-exposure levels as his control. All hormone levels stayed within normal ranges, and circadian patterns of prolactin, thyroid-stimulating hormone, adrenocorticotropin, and testosterone were not disrupted, while growth hormone and cortisol maximum levels decreased significantly during exposure but returned to baseline afterward.
Dasdag S, Akdag MZ, Ulukaya E, Uzunlar AK, Yegin D. · 2008
Apoptosis was assessed by immunohistochemical staining for cleaved caspase-3 in testicular tissue. The exposed group showed no statistically significant difference in apoptosis scores compared to sham and cage control groups.
Bamiou DE, Ceranic B, Cox R, Watt H, Chadwick P, Luxon LM. · 2008
The study used a double blind design with nine case subjects who reported symptoms after prolonged mobile telephone use and 21 control subjects. Each subject underwent 30 min exposures to pulsed RF, continuous RF, or no emission from a dummy phone system at 882 MHz with a maximum SAR of 1.3 W kg−1 (± 30%). Transient evoked otoacoustic emissions showed no significant changes from baseline after any exposure and no differences between cases and controls. Video-oculography detected no effect of exposure on the vestibular end organ in either group.
Türközer Z, Güler G, Seyhan N. · 2008
Researchers aimed to evaluate the effects of varied 50 Hz electric field exposure on lipid peroxidation and antioxidant enzyme activities in guinea pig brain homogenates. Guinea pigs were exposed to electric fields ranging from 2 to 5 kV/m for three days, eight hours per day, in both vertical and horizontal directions. No statistically significant differences were found between exposed and sham groups in lipid peroxidation levels or enzyme activities at any field strength or direction. Comparisons between vertical and horizontal exposure directions also showed no significant differences.
