3,138 Studies Reviewed. 77.4% Found Biological Effects. The Evidence is Clear.
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Brain & Nervous System

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Key Finding: 78% of 1,644 studies on brain & nervous system found biological effects from EMF exposure.

Of 1,644 studies examining brain & nervous system, 78% found measurable biological effects from EMF exposure.

Lowest Documented Effect

Research found effects on brain & nervous system at exposures as low as:

Study Exposure Level in ContextA logarithmic scale showing exposure levels relative to Building Biology concern thresholds and regulatory limits.Study Exposure Level in Context0.0000000043Extreme Concern5 mGFCC Limit2,000 mGEffects observed in the No Concern range (Building Biology)FCC limit is 465,116,279,070x higher than this exposure level

Research Overview

  • -When 81.3% of studies examining EMF effects on the brain and nervous system report biological changes, we're looking at one of the most consistent patterns in EMF research.
  • -Out of 1,344 peer-reviewed studies, 1,092 have documented measurable impacts on neural function, brain activity, and nervous system health.
  • -This isn't a handful of outlier studies or preliminary findings - this represents decades of research from laboratories worldwide showing remarkably consistent results.

When 81.3% of studies examining EMF effects on the brain and nervous system report biological changes, we're looking at one of the most consistent patterns in EMF research. Out of 1,344 peer-reviewed studies, 1,092 have documented measurable impacts on neural function, brain activity, and nervous system health. This isn't a handful of outlier studies or preliminary findings - this represents decades of research from laboratories worldwide showing remarkably consistent results.

Henry Lai's comprehensive analysis of peer-reviewed research, 91% of studies examining extremely low frequency fields found biological effects on the nervous system, while 72% of radiofrequency studies showed similar impacts.

The scientific evidence demonstrates that radiofrequency electromagnetic fields from mobile phones and wireless devices produce measurable effects on nervous system function and cellular processes in the brain.

Source: BioInitiative Working Group. BioInitiative Report: A Rationale for Biologically-based Public Exposure Standards for Electromagnetic Radiation. Edited by Cindy Sage and David O. Carpenter, BioInitiative, 2012, updated 2020. www.bioinitiative.org

Research Statistics by EMF Type

EMF TypeStudiesShowing EffectsPercentage
ELF22920891.00%
RF30522272.00%

Source: Dr. Henry Lai research database, BioInitiative Report

Showing 1,644 studies

STAT3 signalling pathway is involved in the activation of microglia induced by 2.45 GHz electromagnetic fields.

Hao Y, Yang X, Chen C, Yuan-Wang, Wang X, Li M, Yu Z · 2010

Researchers exposed brain immune cells called microglia to 2.45 GHz radiation (the same frequency used in WiFi and microwave ovens) for 20 minutes and found it activated these cells through a specific cellular pathway called STAT3. The activated microglia began producing inflammatory molecules including nitric oxide and tumor necrosis factor-alpha. This matters because microglial activation is linked to brain inflammation and neurological problems.

Effects of GSM signals during exposure to event related potentials (ERPs)

Bak M, Dudarewicz A, Zmyślony M, Sliwinska-Kowalska M · 2010

Researchers exposed 15 volunteers to GSM cell phone radiation for 20 minutes while measuring their brain activity using a test called event-related potentials (ERPs), which tracks how the brain processes information. They found that during EMF exposure, the brain's P300 wave amplitude decreased significantly, but returned to normal levels immediately after exposure ended. This suggests that cell phone radiation can temporarily alter brain function in real-time.

GFAP expression in the rat brain following sub-chronic exposure to a 900 MHz electromagnetic field signal

Ammari M et al. · 2010

Researchers exposed rats to cell phone-level radiation (900 MHz) for 8 weeks and found increased levels of GFAP, a protein that indicates brain inflammation and damage to protective brain cells called astrocytes. The brain damage occurred at radiation levels similar to what people experience during cell phone use, and persisted for at least 10 days after exposure ended.

Exposure to 1800 MHz radiofrequency radiation induces oxidative damage to mitochondrial DNA in primary cultured neurons.

Xu S et al. · 2010

Researchers exposed brain neurons to cell phone radiation at 1800 MHz and found it damaged mitochondrial DNA, the genetic material in cells' energy centers. The radiation increased DNA damage markers and reduced healthy mitochondrial genes. This suggests cell phone radiation may harm brain cells' power-producing structures.

Mutagenic response of 2.45 GHz radiation exposure on rat brain.

Kesari KK, Behari J, Kumar S. · 2010

Researchers exposed rats to 2.45 GHz microwave radiation (the same frequency used in WiFi routers and microwave ovens) for 2 hours daily over 35 days at relatively low power levels. They found significant DNA damage in brain cells, disrupted antioxidant defenses, and changes in proteins that regulate cell division. The authors concluded this chronic exposure pattern may promote brain tumor development.

The effect of radiofrequency radiation on DNA and lipid damage in non-pregnant and pregnant rabbits and their newborns.

Guler G, Tomruk A, Ozgur E, Seyhan N. · 2010

Researchers exposed pregnant and non-pregnant rabbits to cell phone radiation for 15 minutes daily over seven days. Both groups showed significant DNA damage and cellular stress in brain tissue, while newborns were unaffected. This demonstrates measurable biological harm from everyday cell phone exposure levels.

Reactive oxygen species levels and DNA fragmentation on astrocytes in primary culture after acute exposure to low intensity microwave electromagnetic field.

Campisi A et al. · 2010

Italian scientists exposed brain cells to cell phone radiation and found that pulsed signals caused DNA damage and increased harmful molecules called free radicals after 20 minutes. Continuous waves showed no effects, suggesting modulated wireless signals may harm brain cells through non-heating mechanisms.

Brain & Nervous SystemNo Effects Found

Use of wireless telephones and serum S100B levels: A descriptive cross-sectional study among healthy Swedish adults aged 18-65 years.

Söderqvist F, Carlberg M, Hardell L · 2009

Swedish researchers tested whether wireless phone use affects the blood-brain barrier (the protective boundary between blood and brain tissue) by measuring S100B protein levels in blood samples from 1,000 adults. They found no significant association between phone use and elevated S100B levels, suggesting that wireless phones don't appear to compromise blood-brain barrier integrity based on this biomarker.

Cancer & TumorsNo Effects Found

Risk of pituitary tumors in cellular phone users: a case-control study.

Schoemaker MJ, Swerdlow AJ · 2009

British researchers studied 291 people with pituitary tumors (small growths in a brain gland that regulates hormones) and 630 healthy controls to see if cell phone use increased tumor risk. They found no association between cell phone use and pituitary tumors, even among the heaviest users or those who had used phones for over 10 years. This suggests that cell phone radiation doesn't appear to cause this specific type of brain tumor.

Brain & Nervous SystemNo Effects Found

Effect of prenatal exposure to mobile phone on pyramidal cell numbers in the mouse hippocampus: a stereological study.

Rağbetli MC, Aydinlioğlu A, Koyun N, Rağbetli C, Karayel M · 2009

Researchers exposed pregnant mice to mobile phone radiation throughout pregnancy and then examined brain cell counts in their offspring's hippocampus (the brain region crucial for memory and learning). They found no significant difference in the number of pyramidal cells between exposed and unexposed offspring. However, the study lacked important details about exposure levels and duration, making it difficult to assess how these findings relate to human mobile phone use.

Brain & Nervous SystemNo Effects Found

Effects of UMTS Cellular Phones on Human Hearing: Results of the European Project "EMFnEAR".

Parazzini M et al. · 2009

European researchers exposed 134 healthy young adults to radiofrequency radiation from UMTS mobile phones for 20 minutes and tested their hearing immediately before and after exposure. The study found no measurable effects on hearing function, including hearing thresholds, inner ear responses, or brain processing of sound. This suggests that short-term exposure to cell phone radiation at typical usage levels doesn't immediately impact the auditory system.

Brain & Nervous SystemNo Effects Found

Effects of W-CDMA 1950 MHz EMF emitted by mobile phones on regional cerebral blood flow in humans

Mizuno Y et al. · 2009

Japanese researchers used brain scans to study whether 30 minutes of exposure to 3G mobile phone radiation (W-CDMA at 1950 MHz) affects blood flow in the brain. Testing nine healthy men with PET scans before, during, and after phone exposure, they found no significant changes in regional brain blood flow compared to fake exposure. This suggests that 3G phone radiation at typical usage levels doesn't measurably alter blood circulation in the brain.

Brain & Nervous SystemNo Effects Found

The effects of mobile-phone electromagnetic fields on brain electrical activity: a critical analysis of the literature

Marino AA, Carrubba S · 2009

Researchers analyzed 55 studies examining whether mobile phone radiation affects brain electrical activity measured by EEG. They found that 87% of these studies were funded by the wireless industry, and that both positive and negative studies had serious methodological flaws that prevented reliable conclusions. The authors argue that this systematic doubt about EMF effects was manufactured by industry funding rather than reflecting genuine scientific uncertainty.

Brain & Nervous SystemNo Effects Found

Using the nonlinear control of anesthesia-induced hypersensitivity of EEG at burst suppression level to test the effects of radiofrequency radiation on brain function.

Lipping T et al. · 2009

Researchers exposed eleven anesthetized pigs to mobile phone radiation at 890 MHz to test whether radiofrequency signals could trigger brain activity changes in a highly sensitive state. They found no correlation between RF exposure and brain wave patterns, though the animals experienced significant temperature increases (1.6°C) and elevated heart rates during the 10-minute exposures. This suggests that while RF radiation can cause heating effects, it may not directly stimulate brain activity even under conditions of heightened neural sensitivity.

Brain & Nervous SystemNo Effects Found

Preattentive auditory information processing under exposure to the 902 MHz GSM mobile phone electromagnetic field: A mismatch negativity (MMN) study.

Kwon MS et al. · 2009

Researchers tested whether cell phone radiation affects the brain's ability to automatically detect changes in sounds by measuring brain waves in 17 healthy adults while a GSM phone was placed next to their ear. They found no differences in brain responses whether the phone was on or off, suggesting that acute exposure to cell phone radiation doesn't impair this basic auditory processing function. This study adds to research examining how electromagnetic fields might affect brain function during everyday phone use.

Symptoms & SensitivityNo Effects Found

Effects of short-term W-CDMA mobile phone base station exposure on women with or without mobile phone related symptoms.

Furubayashi T et al. · 2009

Researchers exposed 54 women (including 11 with self-reported electromagnetic hypersensitivity) to cell tower radiation at 10 V/m for 30 minutes in a controlled lab setting. Neither group could detect when they were actually being exposed to EMF, and both groups showed identical biological responses whether exposed to real or fake radiation. The study found no evidence that people with electromagnetic hypersensitivity react differently to cell tower emissions than healthy controls.

Brain & Nervous SystemNo Effects Found

Expression of the water channel protein, aquaporin-4, in mouse brains exposed to mobile telephone radiofrequency fields.

Finnie JW, Blumbergs PC, Cai Z, Manavis J. · 2009

Researchers exposed mice to cell phone radiation (900 MHz) for either one hour or repeatedly over two years to see if it would damage the blood-brain barrier - the protective shield that keeps toxins out of the brain. They looked for increased levels of aquaporin-4, a protein that indicates barrier damage. The study found no changes in this protein after either short-term or long-term exposure, suggesting the blood-brain barrier remained intact.

Brain & Nervous SystemNo Effects Found

Heat shock protein induction in fetal mouse brain as a measure of stress after whole of gestation exposure to mobile telephony radiofrequency fields.

Finnie JW, Chidlow G, Blumbergs PC, Manavis J, Cai Z.. · 2009

Researchers exposed pregnant mice to cell phone radiation (900 MHz) for one hour daily throughout pregnancy to see if it caused stress in developing fetal brains. They measured heat shock proteins, which are biological markers that cells produce when under stress. The study found no evidence that the radiation caused stress responses in the fetal brain tissue, suggesting no detectable harm at the exposure levels tested.

Brain & Nervous SystemNo Effects Found

Effects of head-only exposure of rats to GSM-900 on blood-brain barrier permeability and neuronal degeneration.

de Gannes FP et al. · 2009

Researchers exposed rats to cell phone radiation (GSM-900) for 2 hours and checked for brain damage 14 and 50 days later. They found no evidence of blood-brain barrier leakage or neuronal death at exposure levels ranging from very low to high. This study directly contradicted earlier research that claimed similar exposures caused significant brain damage.

Cellular EffectsNo Effects Found

Effects of exposure to DAMPS and GSM signals on Ornithine Decarboxylase (ODC) activity: II. SH-SY5Y human neuroblastoma cells.

Billaudel B et al. · 2009

Researchers exposed human brain tumor cells to cell phone radiation similar to DAMPS and GSM signals for up to 24 hours, then measured changes in an enzyme called ornithine decarboxylase (ODC) that's involved in cell growth. They found no changes in ODC activity regardless of the type of signal, exposure duration, or radiation intensity. This suggests that typical cell phone radiation levels don't affect this particular cellular process in brain cells.

Cancer & TumorsNo Effects Found163 citations

Epidemiologic Evidence on mobile phones and tumor risk: a review.

Ahlbom A et al. · 2009

Researchers from the International Commission for Non-Ionizing Radiation Protection reviewed all available studies on mobile phone use and brain tumor risk through 2009. They found no increased risk of brain tumors within approximately 10 years of mobile phone use, though they noted the observation period may be too short to detect slow-growing tumors that could take decades to develop. The review acknowledged significant methodological problems in existing studies, including biased recall of phone usage patterns.

Brain & Nervous SystemNo Effects Found

Effects of 50 Hz electromagnetic fields on rat cortical synaptosomes.

Aldinucci C et al. · 2009

Italian researchers exposed rat brain nerve terminals (synaptosomes) to 50 Hz magnetic fields at 2 milliTesla for 2 hours and measured multiple indicators of cellular function including energy production, calcium levels, and oxidative stress markers. They found no changes in any of the measured parameters, indicating that this level of extremely low frequency magnetic field exposure did not affect normal nerve terminal function. This suggests that moderate-strength power frequency magnetic fields may not directly disrupt basic brain cell operations at the cellular level.

Learn More

For a comprehensive exploration of EMF health effects including brain & nervous system, along with practical protection strategies, explore these books by R Blank and Dr. Martin Blank.

FAQs: EMF & Brain & Nervous System

When 81.3% of studies examining EMF effects on the brain and nervous system report biological changes, we're looking at one of the most consistent patterns in EMF research. Out of 1,344 peer-reviewed studies, 1,092 have documented measurable impacts on neural function, brain activity, and nervous system health.
The BioInitiative Report database includes 1,644 peer-reviewed studies examining the relationship between electromagnetic field exposure and brain & nervous system. These studies have been conducted by researchers worldwide and published in scientific journals. The research spans multiple decades and includes various types of EMF sources including cell phones, WiFi, power lines, and other common sources of electromagnetic radiation.
78% of the 1,644 studies examining brain & nervous system found measurable biological effects from EMF exposure. This means that 1284 studies documented observable changes in biological systems when exposed to electromagnetic fields. The remaining 22% either found no significant effects or had inconclusive results, which is typical in scientific research where study design and exposure parameters vary.