3,138 Studies Reviewed. 77.4% Found Biological Effects. The Evidence is Clear.
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Cellular Effects

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Key Finding: 83% of 1,453 studies on cellular effects found biological effects from EMF exposure.

Of 1,453 studies examining cellular effects, 83% found measurable biological effects from EMF exposure.

Lowest Documented Effect

Research found effects on cellular effects at exposures as low as:

Study Exposure Level in ContextA logarithmic scale showing exposure levels relative to Building Biology concern thresholds and regulatory limits.Study Exposure Level in Context0.00000000000000009999999999999998558 - 3Extreme Concern1,000 uW/m2FCC Limit10M uW/m2Effects observed in the No Concern range (Building Biology)FCC limit is 100,000,000,000,000,010,000,000x higher than this exposure level

Research Overview

  • -When 81.4% of 269 peer-reviewed studies document cellular effects from electromagnetic field exposure, we're looking at one of the most robust areas of EMF research.
  • -The science demonstrates that our cells respond to EMF exposure in measurable, biological ways that extend far beyond simple heating effects.
  • -These documented cellular effects span a remarkable range of biological processes.

When 81.4% of 269 peer-reviewed studies document cellular effects from electromagnetic field exposure, we're looking at one of the most robust areas of EMF research. The science demonstrates that our cells respond to EMF exposure in measurable, biological ways that extend far beyond simple heating effects. These documented cellular effects span a remarkable range of biological processes.

When we examine the research on cellular effects, we find that 66% of studies published after 2007 show measurable changes in how your cells make and fold proteins when exposed to EMF levels typical of everyday wireless devices.

Research shows that 66% of studies published after 2007 report measurable effects on protein and gene expression at intensity levels commonly used by wireless devices, indicating a clear biological response to EMF exposure at current regulatory limits.

Source: BioInitiative Working Group. BioInitiative Report: A Rationale for Biologically-based Public Exposure Standards for Electromagnetic Radiation. Edited by Cindy Sage and David O. Carpenter, BioInitiative, 2012, updated 2020. www.bioinitiative.org

Showing 1,453 studies

Cancer & TumorsNo Effects Found

DNA synthesis and cell proliferation in C6 glioma and primary glial cells exposed to a 836.55 MHz modulated radiofrequency field.

Stagg RB, Thomas WJ, Jones RA, Adey WR · 1997

Researchers exposed brain cells (both normal and cancerous glioma cells) to cell phone-like radiofrequency radiation at 836.55 MHz for 24 hours to see if it would promote tumor growth by affecting DNA synthesis. While they found small increases in DNA activity in some cancer cell experiments, this didn't translate to actual increased cell growth or proliferation in either normal or cancerous cells.

Immune SystemNo Effects Found

Millemetre waves inhibit the synergistic effect of calcium ionophore A23187 and phorbol ester in neutrophil respiratory burst

Safronova VG et al. · 1997

Russian researchers exposed mouse immune cells (neutrophils) to 41.95 GHz millimeter waves at 150 microW/cm2 for 20 minutes to test effects on the cells' ability to produce reactive oxygen species - their primary defense mechanism. The millimeter waves reduced the cells' immune response by up to 60% when calcium levels were high, but only when calcium could enter the cells from outside. This suggests that millimeter wave radiation can interfere with normal immune cell function by disrupting calcium signaling pathways.

DNA & Genetic DamageNo Effects Found136 citations

Measurement of DNA damage after exposure to electromagnetic radiation in the cellular phone communication frequency band (835.62 and 847.74 MHz).

Malyapa RS et al. · 1997

Researchers exposed mouse and human cells to cell phone frequencies (835-847 MHz) for up to 24 hours at power levels similar to phone use to see if the radiation damaged DNA. Using a sensitive test called the comet assay, they found no DNA damage in the exposed cells compared to unexposed control cells. This suggests that cell phone radiation at typical exposure levels may not directly break DNA strands in laboratory conditions.

Reproductive HealthNo Effects Found

The lack of effects of nonthermal RF electromagnetic fields on the development of rat embryos grown in culture.

Klug S, Hetscher M, Giles S, Kohlsmann S, Kramer K, · 1997

German researchers exposed developing rat embryos to radio frequency electromagnetic fields at various power levels for up to 36 hours to test whether EMF exposure during critical development stages causes birth defects or growth problems. The study found no significant effects on embryo development, growth, or cellular structure across all tested exposure levels, including levels far exceeding typical telecommunication device emissions. This suggests that RF fields at these intensities may not pose developmental risks during embryonic growth.

Brain & Nervous SystemNo Effects Found

Exposure of nerve growth factor-treated PC12 rat pheochromocytoma cells to a modulated radiofrequency field at 836.55 MHz: effects on c-jun and c-fos expression.

Ivaschuk OI et al. · 1997

Researchers exposed rat nerve cells to cell phone radiation at 836.55 MHz (the frequency used by early digital cell phones) to see if it would affect the activity of genes called c-fos and c-jun, which help control cell growth and responses to stress. They found mostly no effects, except for a 38% decrease in c-jun gene activity at the highest exposure level of 9 mW/cm². This suggests that cell phone radiation may have subtle effects on nerve cell gene expression, but only at relatively high exposure levels.

Cellular EffectsNo Effects Found

Extremely high frequency electromagnetic fields at low power density do not affect the division of exponential phase Saccharomyces cerevisiae cells.

Gos, P, Eicher, B, Kohli, J, Heyer, WD · 1997

Researchers exposed yeast cells (Saccharomyces cerevisiae) to extremely high frequency electromagnetic fields around 41.7 GHz at very low power levels to see if the radiation affected how quickly the cells divided. After careful testing with proper controls, they found no significant differences in cell division rates between exposed and unexposed yeast. This contradicts some earlier studies that claimed to find biological effects from similar EMF exposures.

Cancer & TumorsNo Effects Found

Focus formation of C3H/10T1/2 cells and exposure to a 836.55 MHz modulated radiofrequency field.

Cain CD, Thomas DL, Adey WR · 1997

Researchers exposed mouse cells to cell phone-like radiation (836.55 MHz TDMA signals) for 28 days to see if it would enhance cancer cell formation when combined with a known tumor-promoting chemical. The radiation exposure at levels similar to cell phone use did not increase cancer cell formation compared to unexposed cells. This suggests that this type of radiofrequency exposure does not act as a tumor promoter in laboratory cell cultures.

DNA & Genetic DamageNo Effects Found

Effects of high-frequency electromagnetic fields on human lymphocytes in vitro.

Antonopoulos A, Eisenbrandt H, Obe G, · 1997

Researchers exposed human immune cells (lymphocytes) to electromagnetic fields at frequencies used by cell phones and other wireless devices (380, 900, and 1800 MHz) to see if the radiation would damage the cells' DNA or disrupt their normal growth cycle. The study found no measurable differences between cells exposed to EMF and unexposed control cells. This suggests that these specific frequencies, under the conditions tested, did not cause detectable genetic damage or cellular disruption in immune cells.

DNA & Genetic DamageNo Effects Found

Measurement of DNA damage after exposure to electromagnetic radiation in the cellular phone communication frequency band (835.62 and 847.74 MHz).

Malyapa RS et al. · 1997

Researchers exposed two types of cells (mouse and human) to cell phone radiation at frequencies used by mobile phones (835-847 MHz) for up to 24 hours to see if it caused DNA damage. They found no DNA damage in either cell type when exposed at a specific absorption rate (SAR) of 0.6 W/kg, which is below current regulatory limits. This suggests that cell phone radiation at this level may not directly break DNA strands in laboratory conditions.

DNA & Genetic DamageNo Effects Found115 citations

Measurement of DNA damage after exposure to 2450 MHz electromagnetic radiation.

Malyapa RS et al. · 1997

Researchers exposed lab-grown cells to microwave radiation at 2450 MHz (the same frequency used in microwave ovens and older WiFi) for up to 24 hours to see if it would damage DNA. Using a highly sensitive test called the comet assay, they found no DNA damage at either exposure level tested. This contradicted earlier studies that suggested microwave radiation could break DNA strands in brain cells.

Blood-brain barrier permeability in rats exposed to electromagnetic fields used in wireless communication.

Persson BRR, Salford LG, Brun A · 1997

Researchers exposed rats to 915 MHz microwave radiation (similar to cell phone frequencies) for periods ranging from 2 minutes to 16 hours and examined whether this damaged the blood-brain barrier, a critical protective shield that prevents toxins from entering brain tissue. They found that 39% of exposed rats showed abnormal leakage in their blood-brain barrier compared to only 17% of unexposed control rats. This suggests that wireless communication frequencies can compromise the brain's natural protective barrier, potentially allowing harmful substances to reach brain cells.

Evaluation of bone density in rats after hydrocortisone and microwave radiation

Olchowik G · 1997

Researchers exposed rats to both hydrocortisone (a steroid that weakens bones) and microwave radiation for 12 weeks to see how the combination affected bone density. Surprisingly, they found that microwave radiation appeared to protect bone tissue from the bone-weakening effects of the steroid treatment. This unexpected finding suggests microwave exposure might have some protective effects on bones under certain conditions.

Cytogenetic effects of 935.2-MHz (GSM) microwaves alone and in combination with mitomycin C.

Maes A, Collier M, Van Gorp U, Vandoninck S, Verschaeve L · 1997

Researchers exposed human blood cells to 935.2 MHz microwaves (the same frequency used by GSM cell phones) to test whether this radiation could damage DNA or chromosomes. They found no direct genetic damage from the microwaves alone, but discovered a very weak increase in DNA damage when cells were exposed to both microwaves and a known cancer-causing chemical called mitomycin C.

Effects of electromagnetic radiation on embryos of sea-urchins.

Koldayev VM, Shchepin YV, · 1997

Researchers exposed sea urchin embryos to electromagnetic radiation and found it reduced successful fertilization rates while increasing abnormal development. The study revealed that EMR damaged cell membranes, increased harmful oxidation, and disrupted normal cellular processes during early embryonic development. This demonstrates that electromagnetic fields can interfere with fundamental reproductive processes at the cellular level.

Reverse-micelle model: pH, electromagnetic field and inhibitor enzyme interaction.

Chattopadhyay SK, Toews KA, Butt S, Barlett R, Brown HD · 1997

Researchers studied how microwave electromagnetic fields affect enzyme activity using a laboratory model that better mimics conditions inside living cells than traditional test tube experiments. They found that low-intensity microwave fields disrupted the function of two important enzymes (acetylcholinesterase and cytochrome-P450 reductase) in both traditional solutions and the more realistic cellular-like environment. This suggests that EMF effects on enzymes observed in simple laboratory conditions may also occur in the complex environment of actual living cells.

Electromagnetic millimeter waves increase the duration of anaesthesia caused by ketamine and chloral hydrate in mice.

Rojavin MA, Ziskin MC · 1997

Researchers exposed anesthetized mice to millimeter wave radiation at 61.22 GHz and found it extended the duration of anesthesia by approximately 50%. The effect was blocked when mice were pretreated with naloxone (an opioid blocker), suggesting the radiation triggers the release of the body's natural opioids. This demonstrates that millimeter wave exposure can directly alter brain chemistry and nervous system function.

Amino acid concentrations in hypothalamic and caudate nuclei during microwave-induced thermal stress: analysis by microdialysis.

Mason PA et al. · 1997

Researchers exposed rats to high-power 5.02 GHz microwave radiation, heating their brains to dangerous temperatures. This thermal stress significantly increased three amino acid concentrations in critical brain regions including the hypothalamus. The findings suggest microwave heating disrupts normal brain chemistry beyond temperature-control areas.

Bioeffects induced by exposure to microwaves are mitigated by superposition of ELF noise.

Litovitz et al. · 1997

Researchers exposed cells to microwave radiation from cell phones and found it increased activity of an enzyme called ornithine decarboxylase, which is linked to cell growth and potentially cancer. However, when they added low-frequency electromagnetic 'noise' during the exposure, it completely blocked these cellular effects. This suggests that certain types of electromagnetic interference might actually protect cells from microwave damage.

Effects of exposure to electromagnetic radiation at 835 MHz on growth, morphology and secretory characteristics of a mast cell analogue, RBL-2H3.

Donnellan M, McKenzie DR, French PW. · 1997

Researchers exposed immune cells called mast cells to cell phone radiation at 835 MHz for 20 minutes, three times daily for a week. They found that starting on day four, the cells began growing faster, changed shape, and became more reactive to chemical triggers. What's particularly concerning is that these changes persisted for at least a week after the radiation exposure ended, suggesting the effects may be long-lasting.

[Modulated extremely high frequency electromagnetic radiation of low intensity activates or inhibits respiratory burst in neutrophils depending on modulation frequency].

Gapeev AB, Lakushina VS, Chemeris NK, Fesenko EE · 1997

Russian researchers exposed mouse immune cells to extremely high frequency radiation (42 GHz) at low power for 20 minutes. Depending on how the radiation was pulsed, it either boosted or suppressed the cells' infection-fighting ability by 25%, showing weak electromagnetic fields can significantly alter immune function.

Electromagnetic radiation at 835 MHz changes the morphology and inhibits proliferation of a human astrocytoma cell line.

French PW, Donnellan M, McKenzie DR, · 1997

Researchers exposed human brain tumor cells (astrocytoma) to 835 MHz radiation-similar to early cell phone frequencies-for 20 minutes three times daily over a week. They found that lower power levels actually caused more biological effects than higher power levels, including reduced DNA synthesis and dramatic changes in cell shape. This counterintuitive finding suggests that weaker EMF signals may disrupt cellular communication pathways in ways that stronger signals do not.

Effects of exposure to electromagnetic radiation at 835 MHz on growth, morphology and secretory characteristics of a mast cell analogue

Donnellan M, McKenzie DR, French PW · 1997

Researchers exposed immune cells called mast cells to 835 MHz radiofrequency radiation (similar to cell phone frequencies) for 20 minutes three times daily over a week. The exposed cells showed increased DNA synthesis, altered cell shape, and enhanced release of inflammatory substances compared to unexposed cells. These cellular changes persisted for at least a week after the radiation exposure ended, suggesting the effects may trigger lasting biological responses.

Learn More

For a comprehensive exploration of EMF health effects including cellular effects, along with practical protection strategies, explore these books by R Blank and Dr. Martin Blank.

FAQs: EMF & Cellular Effects

When 81.4% of 269 peer-reviewed studies document cellular effects from electromagnetic field exposure, we're looking at one of the most robust areas of EMF research. The science demonstrates that our cells respond to EMF exposure in measurable, biological ways that extend far beyond simple heating effects. These documented cellular effects span a remarkable range of biological processes.
The BioInitiative Report database includes 1,453 peer-reviewed studies examining the relationship between electromagnetic field exposure and cellular effects. These studies have been conducted by researchers worldwide and published in scientific journals. The research spans multiple decades and includes various types of EMF sources including cell phones, WiFi, power lines, and other common sources of electromagnetic radiation.
83% of the 1,453 studies examining cellular effects found measurable biological effects from EMF exposure. This means that 1201 studies documented observable changes in biological systems when exposed to electromagnetic fields. The remaining 17% either found no significant effects or had inconclusive results, which is typical in scientific research where study design and exposure parameters vary.