Sadeghipour R et al. · 2012
Researchers investigated the effects of 100 and 217 Hz extremely low-frequency pulsed electromagnetic fields on cell proliferation, actin reorganization, and ROS generation in human breast carcinoma cells (T47D). Cells were exposed for 24-72 h, at 100 and 217 Hz, 0.1 mT. The treatment induced a time dependent decrease in cell growth after 72 h and revealed an increase in fluorescence intensity in cytoplasm and actin aggregations around the nucleus as detected by fluorescence microscopy. Exposure to 217 Hz for 72 hours caused a dramatic increase in intracellular ROS generation, while exposure to 100 Hz left ROS nearly unchanged.
Janać B et al. · 2012
Researchers exposed young and older gerbils to power-line frequency magnetic fields for seven days. Both age groups showed significant behavioral changes, with younger animals becoming more active. The effects persisted three days after exposure ended, indicating potential lasting impacts on brain function.
Shafiei SA et al. · 2012
Researchers exposed different parts of the brain to extremely low-frequency magnetic fields locally and investigated EEG power spectrum changes at the frequency of stimulation. EEG relative power spectrum was evaluated at 3, 5, 10, 17, and 45 Hz frequencies at T4, T3, F3, Cz, and F4 points, when those points were exposed to magnetic fields at similar frequencies and 100 μT intensity. EEG power did not change significantly at the frequency of stimulation, but significant changes were observed in different EEG bands.
Morabito C, Guarnieri S, Fanò G, Mariggiò MA · 2010
Researchers studied how extremely low frequency electromagnetic fields (ELF-EMFs) of different intensities and durations affected PC12 cells, a cell line used as a neuronal model, during neuronal differentiation. Long-lasting ELF-EMF exposure did not appear to significantly affect proliferation or neuritogenesis. During acute exposure lasting 30 minutes, ROS levels were increased and catalase activity was decreased in undifferentiated PC12 cells, while chronic exposure at 1.0 mT increased catalase activity. Acute exposure affected spontaneous intracellular calcium variations, and basal intracellular calcium was increased after chronic exposure.
Akdag MZ, Dasdag S, Ulukaya E, Uzunlar AK, Kurt MA, Taşkin A · 2010
Researchers exposed rats to extremely low-frequency magnetic fields for 2 hours per day for 10 months, then measured apoptosis and oxidative stress markers in brain tissue. Apoptosis scores and MPO activity were not significantly different between the exposed and sham groups. MDA, TOS, and OSI values were found to be higher in the ELF-500 group than in the ELF-100 and sham groups, and total antioxidative capacity was lower in the ELF-500 group.
Akdag MZ et al. · 2010
Researchers exposed rats to low-frequency magnetic fields at safety-approved levels for 10 months. The fields increased harmful oxidative stress and weakened brain antioxidant defenses without killing cells. This suggests current safety standards may not prevent cellular damage from long-term exposure.
Markkanen A, Naarala J, Juutilainen J · 2010
Murine L929 fibroblast cells were exposed to 50 Hz magnetic fields of 100 or 300 μT during or before UV exposure. No significant magnetic field effects were found, and the results did not support the hypothesis that such fields modify biological responses to UV radiation by changing oxidative reactions.
Akdag MZ et al. · 2010
Researchers exposed rats to extremely low-frequency magnetic fields at levels matching current safety standards for 2 hours daily over 10 months. They found that these exposures significantly increased oxidative stress (cellular damage from free radicals) and weakened the brain's natural antioxidant defenses, though they didn't trigger cell death. This suggests that even magnetic field exposures within current safety limits may cause harmful biochemical changes in brain tissue over time.
Morabito C et al. · 2010
Researchers used C2C12 cells as an in vitro model of the skeletal muscle phenotype to study the effects of short-term exposure to extremely low frequency electromagnetic fields on muscle cell differentiation and function. ELF-EMFs induced reactive oxygen species production in myoblasts and myotubes with a concomitant decrease in mitochondrial membrane potential. The cellular detoxification system was activated, with increases in catalase and glutathione peroxidase activities. ELF-EMFs also altered intracellular calcium homeostasis, increasing the spontaneous activity of myotubes and enhancing cellular reactivity to a depolarizing agent or an agonist of intracellular store calcium channels.
Di Loreto S et al. · 2009
Researchers investigated the effects of exposures to two different 50 Hz sinusoidal ELF magnetic field intensities, 0.1 and 1 mT, on maturing rat cortical neurons. Exposure positively affected cell viability and reduced apoptotic death, with no significant effects on the main antioxidative defences. Linear regression analysis suggested a positive correlation between reduced glutathione and ROS levels in 1 mT magnetic-field-exposed cells. The researchers also observed brain-derived neurotrophic factor over-expression and interleukin 1β-dependent regulation of pro-survival signaling pathways following exposure.
Falone S et al. · 2008
Researchers continuously exposed female Sprague-Dawley rats to a sinusoidal 50 Hz, 0.1 mT magnetic field for 10 days. The study examined antioxidant protection systems and neurotrophic support in brain cortices, as a function of the age of the subjects. Exposure significantly affected antioxidant capability in both young and aged animals, but in opposite ways. The researchers suggested that exposure to these fields may act as a risk factor for oxidative stress-based nervous system pathologies associated with ageing.
Falone S et al. · 2008
Scientists exposed young and old rats to power-line magnetic fields for 10 days. Young rats strengthened their brain's protective systems, but older rats experienced weakened defenses against cellular damage. This suggests aging makes brains more vulnerable to magnetic field exposure from electrical devices.
Yokus B, Akdag MZ, Dasdag S, Cakir DU, Kizil M · 2008
Levels of FapyAde, FapyGua, and 8OHdG were increased at both intensities compared to cage-control and sham groups, but statistical significance was observed only in the group exposed to 100 μT. The researchers noted that the intensity of ELF-MF has an important influence on the extent of DNA damage.
Falone S et al. · 2008
Italian researchers exposed young and older rats to 50 Hz magnetic fields from power lines for 10 days. Young rats strengthened their brain's antioxidant defenses, but older rats experienced significant weakening of these protective systems, suggesting aging brains are more vulnerable to EMF damage.
Akdag MZ, Bilgin MH, Dasdag S, Tumer C · 2007
Carrubba S, Frilot C, Chesson AL, Marino AA. · 2007
Carrubba S, Frilot C, Chesson AL, Marino AA. · 2007
Researchers exposed eight people to weak 60 Hz magnetic fields (1 gauss) for 2 seconds and measured their brain activity using specialized electrodes. They discovered that human brains can detect these low-level magnetic fields and respond in complex, nonlinear ways that standard testing methods miss. This suggests humans may have an evolutionary magnetic sensing ability that makes us vulnerable to artificial electromagnetic fields in our environment.
Yoshikawa T et al. · 2000
Noda Y, Mori A, Liburdy RP, Packer L · 2000
Researchers investigated the effect of pulsed magnetic fields on nitric oxide synthase (NOS) activity in the rat brain. A significant increase in NOS activity was observed in the cerebellum at 111.2±2.0% (P<0.05) for a 1 Gauss (0.1 mT) pulsed DC field, across five separate experiments. Neither AC nor static DC field treatment showed any significant change in NOS activity. In the hippocampus, cortex, medulla oblongata, hypothalamus, striatum, and midbrain, only a slight change or no effect was observed.
Roy S et al. · 1995
Researchers investigated whether a low-frequency, low-intensity magnetic field could affect the oxidative burst triggered by PMA in rat peritoneal neutrophils. In the presence of the magnetic field, a 12.4% increase in the fluorescence signal was observed in PMA-stimulated neutrophils (n = 5, P < 0.02, 18 pairs of measurements). The researchers described this as what they believed to be the first experimental observation of a magnetic field influencing free radical species generated during signal transduction in living cells.
Petrov IR · 1968
The study examined disorders caused by combined ultrahigh frequency electromagnetic waves, using measurement of electromagnetic fields, biological monitoring, and epidemiological approaches. Effects were observed in human subjects and animal models. Exposure to these fields was found to lead to changes in biological systems, including alterations in cellular and molecular structures. Specific findings included impacts on nervous system function, DNA damage, and other physiological responses.
E. ISRAELI, Z. KARNI, Z. SCHUR, D. BARZILAI · 1971
Mizushima, Y., Joseph, R., Sikyta, B. · 1975
Raymond Pautrizel et al. · 1969
Robert A. Facey · 1980
