Jin Z, Zong C, Jiang B, Zhou Z, Tong J, Cao Y. · 2012
Researchers pre-exposed human promyelocytic leukemia HL-60 cells to 900 MHz radiofrequency fields at 12 µW/cm2 power density for 1 hour/day for 3 days, then treated them with doxorubicin at 0.125 mg/L. Radiofrequency exposure alone showed no significant differences from unexposed or sham-exposed control cells. Compared with doxorubicin treatment alone, cells that received radiofrequency pre-exposure before doxorubicin showed increased cell proliferation, decreased apoptosis, increased mitochondrial membrane potential, decreased intracellular calcium, and increased Ca2+-Mg2+-ATPase activity.
Hekmat A, Saboury AA, Moosavi-Movahedi AA. · 2012
Researchers exposed calf thymus DNA to mobile phone radiofrequency fields at 940 MHz, 15 V/m, and a SAR of 40 mW/kg, then examined the DNA immediately after exposure and again two hours after a 45-minute exposure using several laboratory instruments. UV-vis and circular dichroism experiments showed that the EMFs caused disturbance in the DNA structure. Exposed DNA samples were relatively thermally unstable compared to unexposed DNA, and showed more fluorescence emission, which the researchers suggested may have occurred due to expansion of the exposed DNA structure. The structure of the DNA immediately after exposure was not significantly different from the DNA sample two hours after the 45-minute exposure, suggesting the changes were irreversible.
Chen Q et al. · 2012
Researchers studied electrocardiogram (ECG) outcomes in 225 female workers exposed to 27.2 MHz radiofrequency radiation at a shoe factory, comparing them with 100 unexposed female workers from the same factory. The electric field strength the workers were exposed to averaged 64.0 ± 25.2 V/m, which exceeded the 61 V/m International Commission on Non-Ionizing Radiation Protection reference level for occupational exposure. A statistical difference between the exposed and control groups was observed in the rate of sinus bradycardia, but after known cardiovascular risk factors were considered, exposure duration was not found to be an effective factor for ECG changes.
Bortkiewicz A, Gadzicka E, Szymczak W, Zmyślony M. · 2012
Researchers studied whether exposure to EMF from a mobile phone influenced tympanic temperature in ten healthy young men, aged 22.1±4.7 years. Each participant was examined three times: on a sham day with 2×60 minutes of no exposure, on a day with continuous 60-minute exposure followed by 60 minutes of no exposure, and on a day with intermittent exposure alternating 15-minute on and off periods. During continuous exposure, mean tympanic temperature was significantly higher than during sham exposure (p = 0.0001), while during intermittent exposure temperature was lower than on the sham day. The trends in tympanic temperature during the experiment differed significantly in relation to exposure conditions (p < 0.05).
Lu YS, Huang BT, Huang YX. · 2012
Researchers studied reactive oxygen species (ROS) formation and apoptosis in human peripheral blood mononuclear cells (PBMC) exposed to 900 MHz radiofrequency electromagnetic fields at a specific absorption rate of ~0.4 W/kg. ROS was found to play an important role in apoptosis when exposure lasted longer than two hours, with apoptosis induced through the mitochondrial pathway and mediated by activating ROS and caspase-3, and decreasing the mitochondrial potential. The imbalance between antioxidant defenses and ROS formation was associated with about 37% human PBMC death in eight hours.
Güler G et al. · 2012
Researchers exposed infant rabbits to 1800 MHz GSM-like RF radiation and measured lipid peroxidation and DNA damage in their livers. Lipid peroxidation levels in liver tissue increased in both female and male infant rabbits under RF radiation exposure. Liver 8-OHdG levels, a marker of DNA damage, increased in exposed female rabbits but showed no change in exposed male rabbits. The researchers concluded that GSM-like RF radiation may induce biochemical changes by increasing free radical attacks to structural biomolecules in the rabbit model.
Sadeghipour R et al. · 2012
Researchers investigated the effects of 100 and 217 Hz extremely low-frequency pulsed electromagnetic fields on cell proliferation, actin reorganization, and ROS generation in human breast carcinoma cells (T47D). Cells were exposed for 24-72 h, at 100 and 217 Hz, 0.1 mT. The treatment induced a time dependent decrease in cell growth after 72 h and revealed an increase in fluorescence intensity in cytoplasm and actin aggregations around the nucleus as detected by fluorescence microscopy. Exposure to 217 Hz for 72 hours caused a dramatic increase in intracellular ROS generation, while exposure to 100 Hz left ROS nearly unchanged.
Shafiei SA et al. · 2012
Researchers exposed different parts of the brain to extremely low-frequency magnetic fields locally and investigated EEG power spectrum changes at the frequency of stimulation. EEG relative power spectrum was evaluated at 3, 5, 10, 17, and 45 Hz frequencies at T4, T3, F3, Cz, and F4 points, when those points were exposed to magnetic fields at similar frequencies and 100 μT intensity. EEG power did not change significantly at the frequency of stimulation, but significant changes were observed in different EEG bands.
Rageh MM, El-Gebaly RH, El-Bialy NS. · 2012
Researchers exposed newborn rats continuously to a 50 Hz, 0.5 mT extremely low-frequency magnetic field for 30 days, starting when the rats were 10 days old. DNA damage in brain cells, measured by comet assay, was significantly higher in the exposed group. Exposure was associated with a significant four-fold increase in micronucleus induction and about a three-fold increase in mitotic index in bone marrow cells. Exposed rats also showed significantly higher levels of MDA and SOD, while ELF-MF failed to alter the activity of GSH.
Legros A et al. · 2012
Researchers investigated the effects of a 60 Hz, 1,800 μT magnetic field on neurophysiological and neuromotor measures in humans, including EEG, standing balance, voluntary motor function, and physiological tremor. Results suggested a reduction of human standing balance and an increase of physiological tremor amplitude in the frequency range associated with central nervous system contribution, while no exposure effect appeared on EEG or voluntary motor control. The researchers concluded that 1 h of 60 Hz, 1,800 μT magnetic field exposure may modulate human involuntary motor control without being detected in cortical electrical activity.
Korpinar MA, Kalkan MT, Tuncel H. · 2012
Anxiety and stress-related behavioral changes were investigated by elevated plus-maze and hole-board systems. In the elevated plus-maze, exposed rats spent proportionally less time on open arms than control rats (0.12±0.08 versus 0.34±0.18, p <0.01), while hole-board results showed no statistically significant differences between the two groups.
Das S, Kumar S, Jain S, Avelev VD, Mathur R. · 2012
Researchers studied the effect of a 50 Hz, 17.96 μT magnetic field on rats after a hemisection injury of the T13 spinal cord, measuring locomotor function, motor responses to noxious stimuli, and neuronal excitability. Rats were divided into a sham-exposed group and a group exposed to the magnetic field for 2 hours per day for 6 weeks. The magnetic-field-exposed group showed a statistically significant improvement in BBB score over the sham control group, and bladder control was dramatically restored earlier than in the sham group. The researchers suggested that this magnetic field exposure promotes recovery of sensori-motor behavior including locomotion and bladder control in spinal-cord-injured rats.
Spichtig S, Scholkmann F, Chin L, Lehmann H, Wolf M · 2012
Researchers used near-infrared spectroscopy to assess potential effects of UMTS electromagnetic fields on blood circulation in the auditory region of the human head. Three different exposures (sham, 0.18 W/kg, and 1.8 W/kg) were applied in a controlled, randomized, crossover, and double-blind paradigm on 16 healthy volunteers. During exposure to 0.18 W/kg, a significant short-term increase in oxyhaemoglobin and total haemoglobin was found, described as small compared to a functional brain activation. Medium-term heart rate was significantly higher (+1.84 bpm) at 1.8 W/kg than for sham exposure, while the other parameters showed no significant effects.
Schmid MR et al. · 2012
Twenty-five young healthy men took part in a randomized double-blind crossover design, exposed at weekly intervals to different conditions for 30 minutes before sleep. The conditions were a 2-Hz pulse-modulated radio frequency field, a 2-Hz pulsed magnetic field, and sham. Radio frequency exposure increased electroencephalogram power in the spindle frequency range. Delta and theta activity during non-rapid eye movement sleep, and alpha and delta activity during rapid eye movement sleep, were affected following both exposure conditions. No effect on sleep architecture and no clear impact of exposure on cognition was observed.
Schmid MR et al. · 2012
Thirty young healthy men were exposed, at weekly intervals, for 30 minutes directly before an 8-hour sleep period to a 900-MHz RF EMF pulse-modulated at 14 Hz, at 217 Hz, or to a sham control. EEG power in the spindle frequency range was increased during non-rapid eye movement sleep after the 14-Hz pulse-modulated condition, while a similar but non-significant increase was also observed after the 217-Hz condition. No clear exposure-related effects on cognitive performance were seen, and the exposure-induced effect showed considerable individual variability.
Mortazavi SM et al. · 2012
Researchers measured visual reaction time in 160 right-handed university students aged 18 to 31 before and after a 10-minute real or sham exposure to electromagnetic fields emitted by mobile phones. The mean reaction time after real exposure was 286.78 ms and after sham exposure was 295.86 ms (P < 0.001). The researchers also compared reaction times across low-level, moderate, and frequent mobile phone users to assess possible chronic exposure effects. Male students showed shorter reaction times than female students in both talk and standby modes.
Megha K et al. · 2012
Researchers exposed male Fischer-344 rats to 900 MHz and 1800 MHz microwave radiation for 30 days at 2 hours per day to evaluate oxidative stress, cognitive impairment, and inflammation in the brain. Compared with sham-exposed animals, microwave-exposed rats showed significant impairment in cognitive function and oxidative stress in brain tissues. A significant increase in the cytokines IL-6 and TNF-alpha was also observed following microwave exposure.
Loughran SP, McKenzie RJ, Jackson ML, Howard ME, Croft RJ. · 2012
Twenty volunteers each underwent two experimental nights in which they were randomly exposed to either an active or sham condition before a full night of sleep. EEG spectral power was increased in the sleep spindle frequency range in the first 30 minutes of non-REM sleep after active exposure. The increase was more prominent in participants who had already shown an increase in the original study, suggesting the effect is sensitive to individual variability.
Dasdag S, Akdag MZ, Kizil G, Kizil M, Cakir DU, Yokus B · 2012
Researchers exposed male rats to 900 MHz radiofrequency radiation for 2 hours per day, 7 days a week, for 10 months, then measured beta amyloid protein, protein carbonyl, and malondialdehyde in the brain. Beta amyloid protein, protein carbonyl, and malondialdehyde levels were found to be higher in the brains of exposed rats. Only the increase in protein carbonyl was statistically significant (p < 0.001).
Calabrò E et al. · 2012
Khalil AM, Gagaa M, Alshamali A. · 2012
Researchers exposed adult male Sprague-Dawley rats to mobile phone radio frequency radiation from a GSM signal generator at a whole-body specific absorption rate of 1.0 W/kg for 2 hours. Urinary levels of 8-oxodG, described as one major form of oxidative DNA damage, were significantly elevated in exposed rats compared to controls at most time points.
Unknown authors · 2011
Researchers treated Eight patients with probable Alzheimer's disease using daily rTMS-COG sessions 5/week for 6 weeks, then maintenance sessions 2/week for 3 months. The primary cognitive measure ADAS-cog improved by approximately 4 points at both 6 weeks and 4.5 months, and the Clinical Global Impression of Change improved by 1.0 and 1.6 points respectively. Secondary measures MMSE, ADAS-ADL, and Hamilton Depression Scale improved but not significantly, while the Neuropsychiatric Inventory did not change and no side effects were recorded.
Unknown authors · 2011
Unknown authors · 2011
Researchers isolated human peripheral blood mononuclear cells from healthy volunteers and stimulated them with TLR2 and TLR4 ligands and heat-killed microorganisms. The cells were exposed to a controlled ELF-EMF signal at 20-5000 Hz with a DC component of 3 μT and AC component of 5 μT for 30 minutes. Cytokine production (IL-1β, IL-6, TNFα, IL-8, IL-10) was measured at different time points. No significant difference in cytokine production was detected after stimulation with LPS, Pam3Cys, or the panel of microorganisms. The researchers concluded that ELF-EMF does not modulate innate immune response of human primary cells after TLR stimulation in vitro under their experimental conditions.
Unknown authors · 2011
