3,138 Studies Reviewed. 77.4% Found Biological Effects. The Evidence is Clear.
Research Guide

5G vs 4G Radiation: What's Different?

Based on 653 peer-reviewed studies

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People often ask whether 5G is more dangerous than 4G. This question requires understanding how 5G technology differs from previous generations and what research exists on each.

5G networks operate across multiple frequency bands. Low-band 5G (600-900 MHz) is actually similar to 4G frequencies. Mid-band 5G (2.5-4 GHz) overlaps with existing WiFi. High-band 5G (24-40+ GHz, "millimeter wave") represents the newest frequencies for consumer wireless exposure.

This page compares what research shows about radiation exposure from 5G versus 4G technologies.

Key Research Findings

  • 5G uses multiple frequency bands with different characteristics
  • Millimeter waves (high-band 5G) penetrate less deeply into tissue
  • More cell towers can actually reduce individual exposure levels

Related Studies (653)

Effect of electromagnetic radiofrequency radiation on the rats' brain, liver and kidney cells measured by comet assay.

Trosić I et al. · 2011

Researchers exposed rats to cell phone radiation at 915 MHz for one hour daily over two weeks and examined DNA damage in brain, liver, and kidney cells using a comet assay test. They found measurable DNA breaks in liver and kidney cells, with less pronounced effects in brain cells. This suggests that radiofrequency radiation at levels similar to cell phone emissions can cause genetic damage in multiple organs.

Bioassay for assessing cell stress in the vicinity of radio-frequency irradiating antennas

Monselise EB, Levkovitz A, Gottlieb HE, Kost D · 2011

Israeli researchers exposed water plants (duckweed) to radio frequency radiation from AM transmitter antennas for 24 hours and measured cellular stress responses. The plants accumulated alanine, a known stress marker, in direct proportion to the radiation intensity they received. When vitamin C was added, it completely blocked this stress response, suggesting that free radicals (unstable molecules that damage cells) were involved in the process.

Cellular ATP content was decreased by a homogeneous 8.5 T static magnetic field exposure: role of reactive oxygen species.

Zhao G et al. · 2011

Scientists exposed human cells to extremely powerful magnetic fields (8.5 Tesla) and found cellular energy production dropped significantly while harmful molecules increased. The strongest magnetic fields disrupted the cells' ability to make energy, suggesting very intense magnetic exposure could interfere with basic cellular functions.

Cellular EffectsNo Effects Found

2-GHz Band CW and W-CDMA modulated radiofrequency fields have no significant effect on cell proliferation and gene expression profile in human cells.

Takeda H et al. · 2010

Researchers exposed three types of human cells to 2.1 GHz radiofrequency radiation (similar to 3G cell phone signals) for up to 96 hours at various power levels. They found no significant effects on cell growth, survival, or gene activity compared to unexposed cells. The study suggests that RF exposure at levels within current safety guidelines doesn't cause immediate cellular stress or damage.

Cellular EffectsNo Effects Found

2-GHz band CW and W-CDMA modulated radiofrequency fields have no significant effect on cell proliferation and gene expression profile in human cells.

Sekijima M et al. · 2010

Japanese researchers exposed human brain cells and lung cells to 2.1 GHz radiofrequency radiation (similar to 3G cell phones) for up to 96 hours at various power levels. They found no significant changes in cell growth, survival, or gene expression patterns compared to unexposed cells. The study suggests that RF exposure within current safety guidelines doesn't trigger obvious cellular stress responses in laboratory conditions.

Reproductive HealthNo Effects Found

The lack of histological changes of CDMA cellular phone-based radio frequency on rat testis.

Lee HJ et al. · 2010

Researchers exposed male rats to cell phone radiation at 848.5 MHz for 12 weeks to study effects on sperm production and testicular health. They found no changes in sperm count, testicular tissue structure, or markers of cellular damage compared to unexposed rats. This suggests that exposure to this specific frequency and power level did not harm male reproductive function in rats.

Cellular EffectsNo Effects Found

Absence of nonlinear responses in cells and tissues exposed to RF energy at mobile phone frequencies using a doubly resonant cavity.

Kowalczuk C et al. · 2010

Researchers tested whether living cells and tissues can act like radio receivers that convert cell phone frequency signals (883 MHz) into other frequencies. They exposed over 500 samples of human and animal cells and tissues to radiofrequency energy and looked for signs that the biological material was converting the signal. No consistent signal conversion was detected, indicating that living tissue does not demodulate RF energy the way electronic devices do.

Cellular EffectsNo Effects Found

Two-dimensional electrophoretic analysis of radio-frequency radiation-exposed MCF7 breast cancer cells.

Kim KB et al. · 2010

Researchers exposed breast cancer cells (MCF7) to cell phone radiation at 849 MHz for one hour daily over three days, then analyzed whether the radiation changed protein production in the cells. They found no significant or consistent changes in protein expression at either exposure level tested (2 or 10 W/kg SAR). This suggests that radiofrequency radiation at these levels does not alter how cells make proteins, which is important because protein changes can indicate cellular stress or damage.

Brain & Nervous SystemNo Effects Found

1950 MHz IMT-2000 field does not activate microglial cells in vitro.

Hirose H et al. · 2010

Japanese researchers exposed rat brain immune cells called microglia to 1950 MHz cell phone radiation for 2 hours at various power levels, then monitored the cells for signs of activation or inflammation. They found no significant differences between exposed and unexposed cells in terms of immune markers or inflammatory proteins. This suggests that short-term exposure to 3G cell phone frequencies at typical power levels does not trigger immune responses in brain cells.

DNA & Genetic DamageNo Effects Found

Is there any possible genotoxic effect in exfoliated bladder cells of rat under the exposure of 1800 MHz GSM-like modulated radio frequency radiation (RFR)?

Gurbuz N, Sirav B, Yuvaci HU, Turhan N, Coskun ZK, Seyhan N. · 2010

Turkish researchers exposed rats to 1800 MHz cell phone radiation (the same frequency used by GSM networks) for 20 minutes daily over a month to test for DNA damage in bladder cells. They found no increase in micronuclei (cellular markers of genetic damage) compared to unexposed control rats. This suggests that short-term exposure to GSM radiation at these levels did not cause detectable genetic damage to bladder cells.

DNA & Genetic DamageNo Effects Found

Cytogenetic studies in human cells exposed in vitro to GSM-900 MHz radiofrequency radiation using R-banded karyotyping.

Bourthoumieu S et al. · 2010

Researchers exposed human cells to GSM-900 MHz radiation (the type used by 2G mobile phones) for 24 hours to see if it caused genetic damage. Using advanced chromosome analysis techniques, they found no evidence of DNA damage or chromosomal changes at a specific absorption rate of 0.25 W/kg. This study adds to the scientific debate about whether cell phone radiation can harm our genetic material.

Oxidative StressNo Effects Found

A Study on the effects of 50 Hz magnetic fields on UV-induced radical reactions in murine fibroblasts.

Markkanen A, Naarala J, Juutilainen J · 2010

Finnish researchers tested whether 50 Hz magnetic fields (the type from power lines) could amplify DNA damage from UV radiation in mouse cells. They exposed cells to magnetic fields of 100-300 microTesla during or before UV exposure and measured cellular oxidative stress. The study found no evidence that magnetic fields increased UV-induced damage, contradicting their hypothesis about how magnetic fields might affect cellular chemistry.

Cellular EffectsNo Effects Found

Exposure to GSM RF fields does not affect calcium homeostasis in human endothelial cells, rat pheocromocytoma cells or rat hippocampal neurons.

O'Connor RP, Madison SD, Leveque P, Roderick HL, Bootman MD · 2010

Researchers exposed three types of cells (including human blood vessel cells and brain cells) to 900 MHz cell phone radiation at various power levels to see if it affected calcium levels inside the cells. Calcium is crucial for cell function and communication. They found no changes in calcium activity, even at radiation levels higher than typical phone exposure, suggesting that GSM cell phone signals don't disrupt this fundamental cellular process.

Brain & Nervous SystemNo Effects Found

Microglial activation as a measure of stress in mouse brains exposed acutely (60 minutes) and long-term (2 years) to mobile telephone radiofrequency fields

Finnie JW, Cai Z, Manavis J, Helps S, Blumbergs PC · 2010

Researchers exposed mice to 900 MHz cell phone radiation for either 60 minutes or five days a week for two years, then examined their brains for signs of microglial activation - a cellular stress response that occurs when brain tissue is damaged. They found no evidence of brain cell stress or activation at either exposure duration, even at radiation levels much higher than typical cell phone use.

Non-thermal cellular effects of lowpower microwave radiation on the lens and lens epithelial cells.

Yu Y, Yao K. · 2010

Researchers reviewed studies on how low-power microwave radiation affects the eye's lens and its cells. They found that even at power levels below current safety limits, microwave exposure can reduce lens transparency, disrupt normal cell function, and trigger stress responses that could potentially lead to cataracts. This challenges the assumption that only high-power microwaves that cause heating are dangerous to eye health.

Hydrogen bond perturbation in hen egg white lysozyme by external electromagnetic fields: a nonequilibrium molecular dynamics study.

Solomentsev GY, English NJ, Mooney DA · 2010

Researchers used computer simulations to study how microwave radiation (2.45 to 100 GHz) affects the structure of lysozyme, a protein found in egg whites. They found that the electromagnetic fields disrupted hydrogen bonds that help maintain the protein's shape, with the most damage occurring on the protein's outer surface where bonds are naturally weaker. This demonstrates that microwave radiation can alter protein structure at the molecular level, potentially affecting how proteins function in living systems.

Exposure to wireless phone emissions and serum beta-trace protein.

Hardell L, Söderqvist F, Carlberg M, Zetterberg H, Mild KH. · 2010

Researchers measured beta-trace protein, a key enzyme that produces the brain's natural sleep hormone, in 62 young adults who used wireless phones. They found that people who had used wireless phones longer had lower levels of this sleep-promoting protein in their blood. This provides a potential biological explanation for why some people experience sleep problems when exposed to cell phone radiation.

STAT3 signalling pathway is involved in the activation of microglia induced by 2.45 GHz electromagnetic fields.

Hao Y, Yang X, Chen C, Yuan-Wang, Wang X, Li M, Yu Z. · 2010

Researchers exposed brain immune cells called microglia to 2.45 GHz electromagnetic fields (the same frequency used in WiFi and microwaves) and found that this radiation activated inflammatory pathways in the cells. The EMF exposure triggered specific molecular changes that led to increased production of inflammatory proteins and nitric oxide. This matters because activated microglia contribute to brain inflammation, which is linked to neurological problems and brain diseases.

Cranial and postcranial skeletal variations induced in mouse embryos by mobile phone radiation.

Fragopoulou AF, Koussoulakos SL, Margaritis LH. · 2010

Greek researchers exposed pregnant mice to GSM 900MHz cell phone radiation and examined their newborn offspring for developmental abnormalities. While the exposed mice appeared normal externally, detailed microscopic analysis revealed significant variations in bone formation (ossification) in the skull and rib cage, as well as cartilage displacement. These skeletal changes were temporary, disappearing by the time the mice developed teeth, suggesting cell phone radiation may disrupt normal bone development during critical embryonic periods.

Comparison of biological effects between continuous and intermittent exposure to GSM-900-MHz mobile phone radiation: detection of apoptotic cell-death features.

Chavdoula ED, Panagopoulos DJ, Margaritis LH. · 2010

Researchers exposed fruit flies to GSM cell phone radiation for 6 minutes daily and compared continuous versus intermittent exposures. They found that both exposure patterns reduced reproductive capacity and triggered cell death through DNA fragmentation, but flies could partially recover when given longer breaks between exposures. This suggests that constant exposure may be more harmful than intermittent exposure to the same radiation.

Transient DNA damage induced by high-frequency electromagnetic fields (GSM 1.8 GHz) in the human trophoblast HTR-8/SVneo cell line evaluated with the alkaline comet assay.

Franzellitti S et al. · 2010

Researchers exposed human placental cells to 1.8 GHz cell phone signals for up to 24 hours and found that modulated signals (like those used in GSM phones) caused DNA damage, while unmodulated signals did not. The DNA damage was temporary, with cells recovering within 2 hours after exposure ended. This suggests that the specific way cell phone signals are modulated may be more important for biological effects than just the frequency itself.

Further Reading

For a comprehensive exploration of EMF health effects and practical protection strategies, explore these books by R Blank and Dr. Martin Blank.