Ruigrok HJ et al. · 2018
Researchers monitored TRPV1 activation in real time on live cells using a bioluminescence resonance energy transfer technique. Transiently-transfected HEK293T cells were exposed to 1800 MHz radiofrequency signals including CW, GSM, UMTS, LTE, Wi-Fi and WiMAX at specific absorption rates between 8 and 32 W/kg. TRPV1 channels were activated by the heat produced by radiofrequency exposure, but no activation occurred without temperature elevation. Radiofrequency exposure did not alter the maximal efficacy of capsaicin to activate TRPV1 at fixed temperature.
Li R et al. · 2018
This study examined how mouse spermatocyte-derived cells respond to 1800 MHz radiofrequency electromagnetic field exposure at 4 W/kg for 24 hours. The researchers found that RF-EMF exposure induced both DNA damage and autophagy through reactive oxygen species (ROS) generation, with the AMPK/mTOR signaling pathway mediating this autophagy response, and that autophagy activation actually protected cells from DNA damage.
Unknown authors · 2018
Turkish researchers tested whether 15-minute mobile phone exposure affects attention in 30 emergency physicians using standardized cognitive tests. They found that physicians exposed to active phones (900-1800 MHz) actually performed better on selective attention tasks compared to those holding inactive phones. The study suggests short-term phone radiation may temporarily enhance certain cognitive functions.
Gupta SK, Mesharam MK, Krishnamurthy S. · 2018
Male rats were exposed to EMR (900, 1800 and 2450 MHz) every day for 1 h for 28 consecutive days. Animals exposed to EMR-2450 MHz exhibited significant cognitive deficits. EMR-2450 MHz caused loss of mitochondrial function and integrity, an increase in amyloid beta expression. There was release of cytochrome-c and activation of apoptotic factors such as caspase-9 and -3 in the hippocampus. Further, there was decrease in levels of acetylcholine, and increase in activity of acetyl cholinesterase, indicating impairment of cholinergic system.
Lasalvia M et al. · 2018
Researchers exposed human peripheral blood lympho-monocytes in a reverberation chamber to 1.8 GHz electromagnetic fields at 200 V/m for times ranging from 1 to 20 hours. Some exposed cells took on an enlarged and deformed shape, and Raman spectra of the nuclear compartment showed reductions in DNA backbone-linked vibrational modes. After 20 hours of exposure, resting oxygen consumption rate increased and was coupled to a significant increase of the FoF1-ATP synthase-related oxygen consumption. The researchers suggested that adaptive mechanisms, likely via redox signaling, may compensate for early impairments of the oxidative phosphorylation system caused by EMF exposure.
Ertilav K, Uslusoy F, Ataizi S, Nazıroğlu M. · 2018
Twenty-four adult rats were divided into control, 900 MHz, and 1800 MHz exposure groups. Each experimental group was exposed to electromagnetic radiation for 60 minutes per day, five days per week, for one year. Both frequencies increased TRPV1 currents, calcium influx, reactive oxygen species, mitochondrial membrane depolarization, apoptosis, and caspase 3 and 9 activities in the hippocampus and dorsal root ganglion. The 1800 MHz exposure produced greater increases in these measures than the 900 MHz exposure.
Li R et al. · 2018
Mouse spermatocyte-derived cells (GC-2) were exposed to radiofrequency electromagnetic fields at 4 W/kg for 24 hours. The exposure induced both autophagy and DNA damage in GC-2 cells through the generation of reactive oxygen species. When autophagy was blocked by knocking down AMPKα, DNA damage increased, while overexpressing AMPKα promoted autophagy and reduced DNA damage.
Kerimoğlu G, Güney C, Ersöz Ş, Odacı E. · 2018
Twenty-four male Sprague Dawley rats aged 21 days were divided into control, sham, and EMF groups, and the EMF group was exposed to a 900-MHz field for one hour each day from postnatal day 21 to 59. Histopathological examination showed normal Schwann cells and axons in all groups, but marked thickening of the epineurium in the EMF-exposed rats. Biochemical analysis found higher MDA, SOD, and CAT levels in the EMF group versus control and sham, and the apoptotic index was significantly increased in the EMF group.
Jeong YJ et al. · 2018
The aim of the study was to observe the impact of long-term RF-EMF on oxidative stress and neuroinflammation in aging brains of C57BL/6 mice. Compared with young mice, aged mice showed significantly increased protein and lipid oxidative damage markers in the brain. Aged mice also had significantly elevated markers of DNA damage, apoptosis, astrocytes, and microglia. Long-term RF-EMF exposure did not change the levels of oxidative stress, DNA damage, apoptosis, astrocyte, or microglia markers in aged mouse brains. Long-term RF-EMF exposure also did not alter locomotor activity in aged mice.
Chauhan P, Verma HN, Sisodia R, Kesari KK. · 2017
Researchers exposed male Wistar rats to 2.45 GHz microwave radiation at a power density of 0.2 mW/cm2 for 2 hours a day for 35 days, then examined brain, liver, kidney, testis, and spleen. Significantly high levels of lipid peroxide were found in the liver (p < 0.001), brain (p < 0.004), and spleen (p < 0.006) of exposed rats. Histological changes were also observed in the brain, liver, testis, kidney, and spleen after whole-body microwave exposure, compared to the control group.
Eghlidospour M, Ghanbari A, Mortazavi SMJ, Azari H. · 2017
Researchers exposed adult murine neural stem cells to GSM 900-MHz radiofrequency radiation from a mobile phone for varying durations. They used neurosphere assays to evaluate proliferation, immunofluorescence to examine differentiation, and alamarBlue and caspase 3 apoptosis assays to assess harmful effects. Neurosphere number and size and the proportion of cells becoming neurons decreased significantly with longer exposure. Cell viability, apoptosis, and astrocytic differentiation were unchanged.
Ahmed NA, Radwan NM, Aboul Ezz HS, Salama NA · 2017
Researchers exposed adult rats to EMR at a frequency of 900 MHz modulated at 217 Hz, with a power density of 0.02 mW/cm2 and SAR of 1.245 W/kg, and measured oxidative stress parameters in the hippocampus and striatum. EMR exposure produced disturbances in oxidant and antioxidant parameters in both brain regions. Green tea mega EGCG given at the beginning of EMR exposure for two and three months had more beneficial effect against EMR-induced oxidative stress than EGCG given after two months of exposure.
Ahmed NA, Radwan NM, Aboul Ezz HS, Salama NA. · 2017
Researchers exposed rats to cell phone-level radiofrequency radiation (900 MHz) for 2-3 months and found it caused oxidative stress damage in brain regions critical for memory and movement. However, when rats were given green tea extract (EGCG) before or during radiation exposure, it significantly protected against this brain damage. The study suggests that antioxidants may help shield the brain from wireless radiation effects.
Varghese R, Majumdar A, Kumar G, Shukla A. · 2017
Researchers exposed female Sprague Dawley rats to 2.45GHz radiation for 4 hours per day for 45 days and assessed behavioral and oxidative stress parameters. Exposed rats exhibited memory decline and anxiety behavior in the Morris water maze, elevated plus maze, and light-dark box tests. Radiation exposure decreased brain antioxidant enzymes superoxide dismutase, catalase, and reduced glutathione, increased lipid peroxidation, and increased the apoptotic marker caspase 3, while histopathological examination and TNF-α levels showed no significant changes.
Taheri M et al. · 2017
Researchers assessed whether 900 MHz GSM mobile phone radiation and 2.4 GHz Wi-Fi router radiation alter the susceptibility of microorganisms to different antibiotics. The study found that exposure to Wi-Fi and RF simulator radiation can significantly alter inhibition zone diameters and growth rates for Listeria monocytogenes and Escherichia coli. Pure cultures of Listeria monocytogenes and Escherichia coli were exposed to RF-EMFs from a GSM 900 MHz mobile phone simulator and a 2.4 GHz Wi-Fi router.
Wang K et al. · 2017
Researchers exposed mice to 1.8 GHz radiofrequency radiation (similar to cell phone signals) for 30 minutes and found it actually improved their memory performance on recognition tasks. The radiation changed brain cell structure and electrical activity in memory-related brain regions. However, the exposure level used was much higher than what people typically experience from everyday devices.
Pandey N, Giri S, Das S, Upadhaya P. · 2017
Swiss albino mice were exposed to 900 MHz RFR for 4 hours and 8 hours per day for 35 days, with one group terminated after exposure and another kept for an additional 35 days post-exposure. RFR exposure caused mitochondrial membrane depolarization and redox imbalance, along with statistically significant increases in DNA damage index and sperm head defects. Flow cytometry showed a 2.5-fold increase in spermatogonia and decreased spermatids, with reduced turnover ratios indicating premeiotic arrest and low sperm count. Histological alterations included sloughing of immature germ cells, epithelium depletion, and maturation arrest, but all changes showed recovery to varied degrees after the post-exposure period.
Pandey N, Giri S, Das S, Upadhaya P · 2017
Researchers exposed male mice to 900 MHz radiofrequency radiation (the frequency used by many cell phones) for 4-8 hours daily over 35 days. The radiation caused DNA damage in sperm-producing cells and disrupted the normal development of sperm, leading to significantly lower sperm counts. While these effects were reversible after stopping exposure, the study demonstrates that cell phone radiation can interfere with male fertility at the cellular level.
AbstractThe present work investigated the effects of prenatal exposure to radiofrequency waves of conventional WiFi devices on postnatal development and behavior of rat offspring et al. · 2017
Researchers exposed pregnant rats to WiFi radiation (2.45 GHz) for 2 hours daily throughout pregnancy and then tracked their offspring's development. The study found that prenatal WiFi exposure delayed normal brain development during the first 17 days after birth and caused oxidative stress in young rat brains. This suggests that WiFi exposure during pregnancy may harm developing nervous systems.
Othman H et al. · 2017
Researchers exposed pregnant rats to a 2.45 GHz WiFi signal for two hours daily throughout gestation. Offspring were assessed for physical and neurodevelopment during the first 17 postnatal days, anxiety at 28 days, motor behavior at 40-43 days, and cerebral oxidative stress and cholinesterase activity at 28 and 43 days. Prenatal WiFi exposure impaired early neurodevelopment but did not alter emotional or motor behavior in adulthood. It also increased oxidative stress markers and decreased antioxidant enzyme activities at 28 days but not at 43 days, and affected acetylcholinesterase activity in brain and serum.
Halgamuge MN. · 2017
The analysis found that 89.9% of studies reported physiological or morphological effects from mobile phone RF-EMF (p < 0.001). Maize, roselle, pea, fenugreek, duckweeds, tomato, onions, and mungbean appeared especially sensitive to RF-EMF.
Sepehrimanesh M, Kazemipour N, Saeb M, Nazifi S, Davis DL · 2017
Researchers exposed 20 Sprague-Dawley rats to 900 MHz RF-EMF for 0, 1, 2, or 4 hours per day for 30 consecutive days. After 4 hours of daily exposure, ATP synthase beta subunit and hypoxia up-regulated protein 1 precursor were significantly up-regulated. The authors state that these protein increases are related to carcinogenic risk and reproductive damage.
Unknown authors · 2017
Researchers exposed male Wistar rats to 900-MHz EMF for 21 days (60 minutes per day) while a control group received no exposure. EMF exposure caused a significant reduction in pyramidal and granular cells in the hippocampus and Purkinje cells in the cerebellum compared with the other groups. Treatment with folic acid or Boswellia sacra prevented this neuronal loss, resulting in cell counts similar to unexposed controls.
Unknown authors · 2017
Researchers exposed adult rats to 900-MHz cell phone radiation for one hour daily over 21 days and found significant brain cell death in memory and motor control regions. Two natural compounds, folic acid and Boswellia sacra, protected against this brain damage when given alongside the radiation exposure. The study demonstrates that cell phone frequency radiation can kill brain cells, but certain antioxidants may offer protection.
Calabrò E, Magazù S. · 2017
Researchers studied the effects of mobile phone electromagnetic waves on the Amide I and Amide II vibration bands of proteins in bidistilled water solution, using Fourier transform infrared spectroscopy and Fourier self-deconvolution analysis. The proteins used were hemoglobin, myoglobin, bovine serum albumin, and lysozyme. The Amide I band increased significantly (p < 0.05) after 4 h of exposure, while the Amide II band did not change significantly.
