3,138 Studies Reviewed. 77.4% Found Biological Effects. The Evidence is Clear.

EMF Research Studies

Browse 3,138 peer-reviewed studies on electromagnetic field health effects from the BioInitiative Report database.

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Showing 1,014 studies (Rodent Studies)

Formation of Reactive Oxygen Species in L929 Cells after Exposure to 900 MHz RF Radiation with and without Co-exposure to 3-Chloro-4-(dichloromethyl)-5-hydroxy-2(5H)-furanone.

Zeni et al. · 2007

Researchers exposed mouse cells to 900 MHz cell phone radiation for up to 30 minutes to test whether it creates harmful molecules called reactive oxygen species. The radiation did not increase these damaging molecules at any exposure level tested, suggesting no immediate cellular harm.

Oxidative Stress129 citations

Effects of mobile phones on oxidant/antioxidant balance in cornea and lens of rats

Balci M, Devrim E, Durak I · 2007

Turkish researchers exposed rats to cell phone radiation (900 MHz) for 10 minutes four times daily over four weeks and examined eye tissues for signs of oxidative damage. They found increased markers of cellular damage in both the cornea and lens of the eye, indicating that radiofrequency radiation causes oxidative stress in eye tissues. When rats were given vitamin C supplements alongside the radiation exposure, the damage was significantly reduced.

Alteration of Nitric Oxide Production in Rats Exposed to a Prolonged, Extremely Low-Frequency Magnetic Field

Akdag MZ, Bilgin MH, Dasdag S, Tumer C · 2007

Researchers exposed rats to extremely low-frequency magnetic fields (the type produced by power lines and household wiring) for 2 hours daily over 10 months. They found that this exposure significantly reduced nitric oxide levels in the blood, a molecule essential for healthy blood vessel function and immune response. The magnetic field strengths tested were within current safety limits set by international guidelines.

Exposure to extremely low frequency magnetic fields enhances locomotor activity via activation of dopamine D1-like receptors in mice.

Shin EJ et al. · 2007

Researchers exposed mice to extremely low frequency magnetic fields (ELF-MF) for one hour daily and found it significantly increased their movement and activity levels. The magnetic field exposure activated specific dopamine receptors in the brain (D1-like receptors), which are involved in movement control and reward pathways. This suggests that ELF magnetic fields can directly alter brain chemistry and behavior through changes in the dopamine system.

Influence of extremely low frequency magnetic fields on Ca2+ signaling and NMDA receptor functions in rat hippocampus

Manikonda PK et al. · 2007

Researchers exposed young rats to 50 Hz magnetic fields (the same frequency used in power lines) for 90 days and found significant changes in brain chemistry, specifically disrupted calcium signaling in the hippocampus, the brain region critical for memory and learning. The magnetic field exposure altered the activity of key enzymes and reduced the function of NMDA receptors, which are essential for memory formation. These findings suggest that chronic exposure to extremely low frequency magnetic fields may interfere with normal brain function and memory processes.

Studying gene expression profile of rat neuron exposed to 1800MHz radiofrequency electromagnetic fields with cDNA microassay.

Zhao R, Zhang S, Xu Z, Ju L, Lu D, Yao G. · 2007

Chinese researchers exposed rat brain neurons to cell phone-frequency radiation (1800 MHz) for 24 hours at power levels similar to heavy phone use. They found that 34 genes changed their activity levels, affecting how neurons function in areas like cell structure, communication, and metabolism. This demonstrates that radiofrequency radiation can alter the fundamental genetic programming of brain cells.

DNA & Genetic DamageNo Effects Found

Gene expression does not change significantly in C3H 10T(1/2) cells after exposure to 847.74 CDMA or 835.62 FDMA radiofrequency radiation.

Whitehead TD, Moros EG, Brownstein BH, Roti Roti JL · 2006

Researchers exposed mouse cells to cell phone radiation (CDMA and FDMA signals) for 24 hours at high power levels to see if it would change gene activity. They found no significant changes in gene expression from either type of cell phone radiation, even though X-ray radiation used as a control clearly altered gene activity. This suggests that these particular radiofrequency exposures did not trigger cellular stress responses at the genetic level.

DNA & Genetic DamageNo Effects Found

Investigation of Co-genotoxic Effects of Radiofrequency Electromagnetic Fields In Vivo.

Verschaeve et al. · 2006

Researchers exposed female rats to mobile phone radiation (900 MHz) for 2 hours daily over 2 years, while also giving them a known cancer-causing chemical in their drinking water. They wanted to see if the radiation would make the chemical's DNA damage worse. The study found no evidence that the radiofrequency radiation enhanced the genetic damage caused by the toxic chemical.

Cancer & TumorsNo Effects Found0

Effects of mobile-phone microwave on dimethylbenz (a) anthracene induced mammary carcinoma development in rats.

Shen YH, Yu D, Fu YT, Chiang H. · 2006

Chinese researchers exposed 500 female rats to cell phone radiation (900 MHz GSM signals) for 4 hours daily over 26 weeks after giving them a chemical known to cause breast tumors. They tested different radiation levels, including some well above typical phone exposure. The study found no difference in breast cancer rates between exposed and unexposed rats - about one-third developed tumors regardless of radiation exposure.

Cellular EffectsNo Effects Found

Effect of GSM-900 and -1800 signals on the skin of hairless rats. II: 12-week chronic exposures.

Sanchez S et al. · 2006

French researchers exposed hairless rats to cell phone radiation (GSM-900 and GSM-1800 signals) for 2 hours daily over 12 weeks to study effects on skin health. They found no significant changes in skin thickness, cell growth patterns, or key structural proteins compared to unexposed rats. This suggests that chronic exposure to these specific cell phone frequencies at the tested levels did not cause detectable skin damage in this animal model.

Immune SystemNo Effects Found

Effects of GSM-modulated radiofrequency electromagnetic fields on B-cell peripheral differentiation and antibody production.

Nasta F et al. · 2006

Researchers exposed mice to cell phone radiation (900 MHz GSM signals) for 2 hours daily over 4 weeks to test whether it affects immune system function, specifically B-cells that produce antibodies to fight infections. They found no changes in B-cell development, antibody production, or immune responses compared to unexposed mice. This suggests that this level of cell phone radiation exposure doesn't impair the immune system's ability to protect against disease.

Cellular EffectsNo Effects Found

Effect of GSM-900 and -1800 signals on the skin of hairless rats. I: 2-hour acute exposures.

Masuda H et al. · 2006

French researchers exposed hairless rats to cell phone radiation (GSM-900 and GSM-1800 signals) for 2 hours at high intensity levels (5 W/kg SAR) and examined their skin tissue for damage. They found no changes in skin thickness, cell death, cell growth patterns, or key skin proteins compared to unexposed animals. This suggests that acute exposure to these cell phone frequencies at high levels does not cause immediate visible damage to skin tissue.

Cellular EffectsNo Effects Found

Radiofrequency radiation does not induce stress response in human T-lymphocytes and rat primary astrocytes.

Lee JS, Huang TQ, Kim TH, Kim JY, Kim HJ, Pack JK, Seo JS. · 2006

Researchers exposed human immune cells and rat brain cells to cell phone-level radiofrequency radiation (1763 MHz) at power levels of 2 and 20 W/kg for up to one hour while carefully controlling temperature. They found no activation of cellular stress responses, including heat shock proteins and stress-signaling pathways that typically activate when cells are damaged. This suggests that RF radiation at these levels does not trigger the cellular alarm systems that respond to harmful stressors.

Cancer & TumorsNo Effects Found

No effects of radiofrequency radiation on 3-Chloro-4-(dichloromethyl)-5-hydroxy-2(5H)-furanone-Induced tumorigenesis in female Wistar rats.

Heikkinen et al. · 2006

Finnish researchers exposed female rats to 900 MHz radiofrequency radiation (similar to cell phone frequencies) for 2 hours daily over 2 years while also giving them a known cancer-causing chemical in their drinking water. The study aimed to see if RF radiation would make tumors more likely to develop. The researchers found no evidence that RF radiation increased cancer risk, even when combined with a chemical known to cause tumors.

Brain & Nervous SystemNo Effects Found

Expression of the immediate early gene, c-fos, in fetal brain after whole of gestation exposure of pregnant mice to global system for mobile communication microwaves.

Finnie JW, Cai Z, Blumbergs PC, Manavis J, Kuchel TR. · 2006

Researchers exposed pregnant mice to 900 MHz cell phone radiation for one hour daily throughout pregnancy to see if it would stress developing fetal brains. They measured c-fos, a protein that appears when brain cells are under stress. The study found no difference in stress markers between exposed and unexposed fetal brains, suggesting this level of radiation didn't cause detectable neural stress during development.

Brain & Nervous SystemNo Effects Found

Effect of mobile telephony on blood-brain barrier permeability in the fetal mouse brain.

Finnie JW, Blumbergs PC, Cai Z, Manavis J, Kuchel TR. · 2006

Researchers exposed pregnant mice to cell phone-like radiation (900 MHz) for one hour daily throughout pregnancy to see if it would damage the blood-brain barrier in developing fetal brains. The blood-brain barrier is a protective filter that prevents harmful substances from entering brain tissue. They found no damage to this protective barrier in any brain region examined, suggesting the radiation exposure did not compromise brain protection during development.

DNA & Genetic DamageNo Effects Found

Investigation of co-genotoxic effects of radiofrequency electromagnetic fields in vivo.

Verschaeve L et al. · 2006

Researchers exposed female rats to cell phone radiation (900 MHz) for 2 years while also giving them a known cancer-causing chemical in their drinking water to see if the radiation would make DNA damage worse. They found that the radiation alone didn't cause genetic damage, and it didn't increase the DNA damage caused by the chemical. This suggests that long-term exposure to cell phone-level radiation may not enhance the harmful effects of other toxins on our genetic material.

The Effects of Pulsed 860 MHz Radiofrequency Radiation on the Promotion of Neurogenic Tumors in Rats.

Zook BC,Simmens SJ. · 2006

Researchers exposed 1,080 rats to pulsed 860 MHz radiofrequency radiation (similar to cell phone signals) for 6 hours daily to see if it would accelerate tumor development in animals already given a cancer-causing chemical. After examining over 1,200 brain and nervous system tumors, they found no evidence that RF exposure affected tumor incidence, growth rate, severity, or how quickly tumors appeared. This suggests that this particular RF signal did not act as a tumor promoter in this animal model.

GSM radiation triggers seizures and increases cerebral c-Fos positivity in rats pretreated with subconvulsive doses of picrotoxin.

Lopez-Martin E et al. · 2006

Spanish researchers studied whether cell phone radiation could trigger seizures in rats that were already vulnerable to seizures (treated with a brain chemical called picrotoxin). When exposed to 900 MHz GSM radiation similar to mobile phones for 2 hours, these seizure-prone rats developed actual seizures and showed increased brain activity markers, while control rats without radiation exposure did not seize. This suggests cell phone radiation might worsen seizure risk in individuals who are already neurologically vulnerable.

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