Hong I et al. · 2018
Researchers delivered low intensity repetitive magnetic stimulation (LI-rMS) at 10 mT and at frequencies of 1 Hz and 10 Hz to B50 rat neuroblastoma cells in vitro for 10 minutes. Both frequencies depleted selected tricarboxylic acid (TCA) cycle metabolites without affecting the main energy supplies. The effects were frequency-specific, with 1 Hz stimulation having stronger effects than 10 Hz. The observed depletion of metabolites suggested that higher spontaneous activity may have led to an increase in GABA release.
Kazemi M et al. · 2018
Researchers exposed male rhesus macaques to extremely low frequency magnetic fields at 0.7 μT for 4 hours per day over 30 consecutive days, at either 1 Hz or 12 Hz. Visual working memory scores and plasma melatonin levels increased significantly in the animals exposed to 12 Hz, but not in those exposed to 1 Hz. NMDA receptor gene expression also increased at 12 Hz exposure, while hippocampal volume did not increase significantly at either frequency.
Laszlo AM et al. · 2018
Researchers exposed turkeys to extremely low frequency electromagnetic fields (50 Hz; 10 μT) for 3 weeks and then observed the birds for a 5-week regeneration period without exposure. Norepinephrine-activated β-adrenoceptor function decreased in the treated birds in a time-dependent manner, while toxicological parameters in the serum showed no differences compared to normal ranges. The decreased β-adrenoceptor function was compensated by the homeostatic complex during the 5-wk regeneration period.
Zuo H, Liu X, Wang D, Li Y, Xu X, Peng R, Song T. · 2018
Researchers created an Alzheimer's disease rat model using D-galactose and Aβ25-35 injections, then exposed the animals to 50 Hz and 400 µT ELF-MF for 60 continuous days. ELF-MF exposure partially improved the cognitive disorder and upregulated the levels of RKIP, TAK1, and the RKIP/TAK1 interaction, but downregulated p-IKK levels in AD rats. The researchers suggested that ELF-MF exposure might have a potential therapeutic value for AD.
Kerimoğlu G, Güney C, Ersöz Ş, Odacı E. · 2018
Twenty-four male Sprague Dawley rats aged 21 days were divided into control, sham, and EMF groups, and the EMF group was exposed to a 900-MHz field for one hour each day from postnatal day 21 to 59. Histopathological examination showed normal Schwann cells and axons in all groups, but marked thickening of the epineurium in the EMF-exposed rats. Biochemical analysis found higher MDA, SOD, and CAT levels in the EMF group versus control and sham, and the apoptotic index was significantly increased in the EMF group.
Esmaeilpour K et al. · 2018
Hippocampal kindled rats showed deficits in learning and memory in the passive-avoidance test. Low-frequency stimulation reversed the impairment in learning and memory behavior in kindled rats. Low-frequency stimulation also diminished kindling-induced neuronal loss and atrophy in the hippocampus. The stimulation protocol used 200 monophasic square wave pulses of 0.1 ms duration at 1 Hz, delivered in four packages every five minutes.
Jeong YJ et al. · 2018
The aim of the study was to observe the impact of long-term RF-EMF on oxidative stress and neuroinflammation in aging brains of C57BL/6 mice. Compared with young mice, aged mice showed significantly increased protein and lipid oxidative damage markers in the brain. Aged mice also had significantly elevated markers of DNA damage, apoptosis, astrocytes, and microglia. Long-term RF-EMF exposure did not change the levels of oxidative stress, DNA damage, apoptosis, astrocyte, or microglia markers in aged mouse brains. Long-term RF-EMF exposure also did not alter locomotor activity in aged mice.
Chauhan P, Verma HN, Sisodia R, Kesari KK. · 2017
Researchers exposed male Wistar rats to 2.45 GHz microwave radiation at a power density of 0.2 mW/cm2 for 2 hours a day for 35 days, then examined brain, liver, kidney, testis, and spleen. Significantly high levels of lipid peroxide were found in the liver (p < 0.001), brain (p < 0.004), and spleen (p < 0.006) of exposed rats. Histological changes were also observed in the brain, liver, testis, kidney, and spleen after whole-body microwave exposure, compared to the control group.
Roser K et al. · 2017
Researchers measured personal RF-EMF exposure in 90 adolescents aged 13 to 17 years using a portable ExpoM-RF device across 13 frequency bands from 470 to 3600 MHz for three consecutive days with a time-activity diary. Mobile phones contributed 67.2% and mobile phone base stations contributed 19.8% of total personal RF-EMF measurements averaging 63.2 μW/m² (0.15 V/m). WLAN at school and home accounted for 3.5% of total personal measurements. Environmental sources contributed on average 6.0% to the brain dose and 9.0% to the whole-body dose according to dose calculations.
Fathi E et al. · 2017
Researchers exposed adipose tissue-derived mesenchymal stem cells to 0.432 μg/ml ZnSO4 together with a 50 Hz, 20 mT electromagnetic field. The combined treatment increased expression of osteogenic genes, alkaline phosphatase activity, and calcium levels. The effect depended on PKA and ERK1/2 signaling, as inhibitors of these pathways blocked the osteogenic promotion. The treatment also raised cAMP and PKA activity and upregulated Wnt/β-catenin pathway genes.
Cichoń N, Bijak M, Miller E, Saluk J. · 2017
Researchers investigated the effect of ELF-EMF on clinical and antioxidant status in post-stroke patients. Fifty-seven patients were divided into two groups: ELF-EMF and non-ELF-EMF, and both groups underwent the same 4-week rehabilitation program. The ELF-EMF group was additionally exposed to a field of 40 Hz, 7 mT for 15 min/day for 4 weeks, 5 days a week. ELF-EMF significantly increased enzymatic antioxidant activity, though total antioxidant status levels did not change in either group.
Unknown authors · 2017
The study evaluated the combined effect of 100 μM temozolomide and a 100 Hz, 100 G electromagnetic field on U87 and T98G human glioma cell lines. Co-treatment synergistically increased apoptosis in both cell lines by raising P53, Bax, and Caspase-3 expression and lowering Bcl-2 and Cyclin-D1 expression. The combination also increased reactive oxygen species production and overexpressed the heme oxygenase-1 gene compared to controls.
Eghlidospour M, Ghanbari A, Mortazavi SMJ, Azari H. · 2017
Researchers exposed adult murine neural stem cells to GSM 900-MHz radiofrequency radiation from a mobile phone for varying durations. They used neurosphere assays to evaluate proliferation, immunofluorescence to examine differentiation, and alamarBlue and caspase 3 apoptosis assays to assess harmful effects. Neurosphere number and size and the proportion of cells becoming neurons decreased significantly with longer exposure. Cell viability, apoptosis, and astrocytic differentiation were unchanged.
Calcabrini C et al. · 2017
Researchers investigated whether ELF-EMF exposure causes significant cell damage in human keratinocytes, to support potential ELF-EMF use in regenerative medicine for skin injuries. Reactive oxygen species production was evaluated in human keratinocytes exposed for 1 H to 50 Hz ELF-EMF at field strengths from 0.25 to 2 G, and significant ROS increases resulted at 0.5 and 1 G. All significant alterations observed in the first 4 H of exposure reverted to controls 24 H after, and the exposure did not have a cytotoxic effect.
Ahmed NA, Radwan NM, Aboul Ezz HS, Salama NA · 2017
Researchers exposed adult rats to EMR at a frequency of 900 MHz modulated at 217 Hz, with a power density of 0.02 mW/cm2 and SAR of 1.245 W/kg, and measured oxidative stress parameters in the hippocampus and striatum. EMR exposure produced disturbances in oxidant and antioxidant parameters in both brain regions. Green tea mega EGCG given at the beginning of EMR exposure for two and three months had more beneficial effect against EMR-induced oxidative stress than EGCG given after two months of exposure.
Ahmed NA, Radwan NM, Aboul Ezz HS, Salama NA. · 2017
Researchers exposed rats to cell phone-level radiofrequency radiation (900 MHz) for 2-3 months and found it caused oxidative stress damage in brain regions critical for memory and movement. However, when rats were given green tea extract (EGCG) before or during radiation exposure, it significantly protected against this brain damage. The study suggests that antioxidants may help shield the brain from wireless radiation effects.
Varghese R, Majumdar A, Kumar G, Shukla A. · 2017
Researchers exposed female Sprague Dawley rats to 2.45GHz radiation for 4 hours per day for 45 days and assessed behavioral and oxidative stress parameters. Exposed rats exhibited memory decline and anxiety behavior in the Morris water maze, elevated plus maze, and light-dark box tests. Radiation exposure decreased brain antioxidant enzymes superoxide dismutase, catalase, and reduced glutathione, increased lipid peroxidation, and increased the apoptotic marker caspase 3, while histopathological examination and TNF-α levels showed no significant changes.
Taheri M et al. · 2017
Researchers assessed whether 900 MHz GSM mobile phone radiation and 2.4 GHz Wi-Fi router radiation alter the susceptibility of microorganisms to different antibiotics. The study found that exposure to Wi-Fi and RF simulator radiation can significantly alter inhibition zone diameters and growth rates for Listeria monocytogenes and Escherichia coli. Pure cultures of Listeria monocytogenes and Escherichia coli were exposed to RF-EMFs from a GSM 900 MHz mobile phone simulator and a 2.4 GHz Wi-Fi router.
Wang K et al. · 2017
Researchers exposed mice to 1.8 GHz radiofrequency radiation (similar to cell phone signals) for 30 minutes and found it actually improved their memory performance on recognition tasks. The radiation changed brain cell structure and electrical activity in memory-related brain regions. However, the exposure level used was much higher than what people typically experience from everyday devices.
Pandey N, Giri S, Das S, Upadhaya P. · 2017
Swiss albino mice were exposed to 900 MHz RFR for 4 hours and 8 hours per day for 35 days, with one group terminated after exposure and another kept for an additional 35 days post-exposure. RFR exposure caused mitochondrial membrane depolarization and redox imbalance, along with statistically significant increases in DNA damage index and sperm head defects. Flow cytometry showed a 2.5-fold increase in spermatogonia and decreased spermatids, with reduced turnover ratios indicating premeiotic arrest and low sperm count. Histological alterations included sloughing of immature germ cells, epithelium depletion, and maturation arrest, but all changes showed recovery to varied degrees after the post-exposure period.
Pandey N, Giri S, Das S, Upadhaya P · 2017
Researchers exposed male mice to 900 MHz radiofrequency radiation (the frequency used by many cell phones) for 4-8 hours daily over 35 days. The radiation caused DNA damage in sperm-producing cells and disrupted the normal development of sperm, leading to significantly lower sperm counts. While these effects were reversible after stopping exposure, the study demonstrates that cell phone radiation can interfere with male fertility at the cellular level.
AbstractThe present work investigated the effects of prenatal exposure to radiofrequency waves of conventional WiFi devices on postnatal development and behavior of rat offspring et al. · 2017
Researchers exposed pregnant rats to WiFi radiation (2.45 GHz) for 2 hours daily throughout pregnancy and then tracked their offspring's development. The study found that prenatal WiFi exposure delayed normal brain development during the first 17 days after birth and caused oxidative stress in young rat brains. This suggests that WiFi exposure during pregnancy may harm developing nervous systems.
Othman H et al. · 2017
Researchers exposed pregnant rats to a 2.45 GHz WiFi signal for two hours daily throughout gestation. Offspring were assessed for physical and neurodevelopment during the first 17 postnatal days, anxiety at 28 days, motor behavior at 40-43 days, and cerebral oxidative stress and cholinesterase activity at 28 and 43 days. Prenatal WiFi exposure impaired early neurodevelopment but did not alter emotional or motor behavior in adulthood. It also increased oxidative stress markers and decreased antioxidant enzyme activities at 28 days but not at 43 days, and affected acetylcholinesterase activity in brain and serum.
Halgamuge MN. · 2017
The analysis found that 89.9% of studies reported physiological or morphological effects from mobile phone RF-EMF (p < 0.001). Maize, roselle, pea, fenugreek, duckweeds, tomato, onions, and mungbean appeared especially sensitive to RF-EMF.
Hedendahl LK, Carlberg M, Koppel T, Hardell L. · 2017
Eighteen teachers from seven schools carried a body-borne exposimeter in school to measure radiofrequency radiation exposure. The mean exposure to RF radiation ranged from 1.1 to 66.1 µW/m² across the schools. The highest mean level recorded was 396.6 µW/m² during 5 minutes of a lesson when the teacher let students stream and watch YouTube videos.
