Narayanan SN et al. · 2010
Healthy male albino Wistar rats were exposed to RF-EMR by giving 50 missed calls per day for 4 weeks with a GSM mobile phone in vibratory mode in the cage. Passive avoidance behaviour was significantly affected in exposed rats, shown as shorter entrance latency to the dark compartment compared to control rats. Marked morphological changes were observed in the CA3 region of the hippocampus of exposed rats compared to control rats. Mobile phone RF-EMR exposure significantly altered passive avoidance behaviour and hippocampal morphology in rats.
Wang XW et al. · 2010
Tillmann T et al. · 2010
Researchers exposed mice to UMTS fields at 0, 4.8, and 48 W/m(2) for up to 24 months starting from embryo-fetal exposure, with the 4.8 W/m(2) group also receiving prenatal ethylnitrosourea at 40 mg ENU/kg body weight. The high-level UMTS exposure (48 W/m(2)) showed tumour incidences comparable to sham and cage control groups. Mice given ethylnitrosourea and exposed to 4.8 W/m(2) UMTS had higher lung tumour rates and more lung carcinomas than ethylnitrosourea-only controls. Lung carcinoma multiplicity increased and the number of metastasising lung tumours doubled in the combined exposure group.
Pinto R et al. · 2010
Jorge-Mora T et al. · 2010
Grigoriev YG et al. · 2010
Researchers replicated earlier Soviet studies from 1974 to 1991 that had examined immunological and reproductive effects of long-term low-level radiofrequency exposure in rats. Wistar rats were exposed in the far field to 2450 MHz continuous wave RF fields at an incident power density of 5 W/m² for 7 hours per day, 5 days per week, for a total of 30 days, resulting in a whole-body SAR of 0.16 W/kg. The results partly confirmed the earlier findings and indicated possible effects from non-thermal RF exposure on autoimmune processes. A separate part of the study suggested possible adverse effects of blood serum from exposed rats on pregnancy and foetal development of intact rats, though the researchers noted that applying these results to exposure standards is limited.
Eşmekaya MA, Seyhan N, Omeroğlu S. · 2010
Researchers exposed two-month-old male Wistar rats to 900 MHz pulse-modulated RF radiation at a SAR of 1.35 Watt/kg for 20 min/day for three weeks. The study examined thyroid gland tissue using light microscopy, electron microscopy, and immunohistochemical methods. Morphological analyses revealed hypothyrophy of the gland, and the results indicated that thyroid hormone secretion was inhibited by the RF radiation. Apoptotic bodies were observed, and caspase-3 and caspase-9 activities were increased in thyroid cells of exposed rats.
Bartsch H et al. · 2010
Researchers exposed unrestrained female Sprague-Dawley rats to a low-intensity GSM-like signal (900 MHz pulsed with 217 Hz, 100 µW/cm² average power flux density) across four experiments conducted from 1997 to 2008. In the life-long experiments, median survival was significantly shortened under RF-exposure by 9.06% (95% CI 2.7 to 15.0%) (p=0.0064), amounting to 72 days in experiment III and 77 days in experiment IV.
Kesari KK, Kumar S, Behari J. · 2010
Researchers exposed male Wistar rats to mobile phone frequencies at 0.9 W/kg specific absorption rate for 2 hours per day over 35 days. A significant decrease in protein kinase C and total sperm count, along with increased apoptosis, were observed in the exposed rats. The results suggest that a reduction in protein kinase activity may be related to overproduction of reactive oxygen species under microwave field exposure.
Kesari KK, Behari J. · 2010
Sperm GPx and SOD activity showed a significant decrease in exposed rats, while catalase showed a significant increase compared with the control group. The percentage of apoptosis was higher in the exposed group, and significant decreases were found in the S phase and G2/M transition phase of the cell cycle. The researchers concluded that these radiations may have a significant effect on the reproductive system of male rats, which may be an indication of male infertility.
Grigor'ev IuG et al. · 2010
Tayefi H et al. · 2010
Frahm J, Mattsson MO, Simkó M. · 2010
Researchers exposed mouse macrophages to a 50 Hz, 1.0 mT magnetic field and measured changes in reactive oxygen species production and protein expression. Short-term exposures of two hours or less caused slight and transient decreases in several proteins, including clathrin, adaptin, PI3-kinase, protein kinase B, and PP2A, while longer exposures had no effect on these proteins. The stress proteins Hsp70 and Hsp110 showed increased levels at certain time points but not generally.
Ciejka E, Skibska B, Kleniewska P, Goraca A. · 2010
Researchers studied the influence of a low-frequency magnetic field on oxidative stress markers in rat muscles. Thirty male rats weighing 280 to 300 grams were randomly divided into three experimental groups, each containing seven animals. One treatment group was exposed to 40 Hz and 7 mT for 0.5 hours per day for 14 days, and the other was exposed at the same settings for 1 hour per day for 14 days. Exposure caused a significant increase in sulfhydryl group concentration and a decrease in protein concentration in the muscle homogenates.
Kumar S, Jain S, Behari J, Avelev VD, Mathur R. · 2010
Researchers studied the effect of magnetic field exposure on food intake, water intake, and body weight in rats with complete spinal cord injury. Exposure ran at 50 Hz and 17.9 T for 2 hours per day over 8 weeks in rats with complete spinal cord transection at the T13 level. The results suggest a significant beneficial effect of chronic exposure to magnetic field of paraplegic rats.
Gulturk S et al. · 2010
Rats in the magnetic field groups were exposed to a 5 mT field for 165 minutes every day for 30 days, and all rats underwent Evans blue measurement to evaluate the blood-brain barrier. Diabetes and magnetic field exposure each increased blood-brain barrier permeability, their combination caused a greater increase, and insulin reduced that effect.
Cuccurazzu B et al. · 2010
The exposure significantly enhanced neurogenesis in the dentate gyrus, with increased numbers of cells labeled for markers of new and developing neurons. Roughly half of the newly generated neurons survived 30 days after stimulation and became mature neurons integrated into the granule cell layer. The new mature neurons were associated with increased long-term potentiation, indicating an influence on hippocampal synaptic plasticity.
Akdag MZ, Dasdag S, Ulukaya E, Uzunlar AK, Kurt MA, Taşkin A · 2010
Researchers exposed rats to extremely low-frequency magnetic fields for 2 hours per day for 10 months, then measured apoptosis and oxidative stress markers in brain tissue. Apoptosis scores and MPO activity were not significantly different between the exposed and sham groups. MDA, TOS, and OSI values were found to be higher in the ELF-500 group than in the ELF-100 and sham groups, and total antioxidative capacity was lower in the ELF-500 group.
Sonmez OF, Odaci E, Bas O, Kaplan S · 2010
Researchers exposed 16-week-old adult female rats to 900 MHz EMF for 1 hour per day for 28 days and then counted Purkinje cells in the cerebellum using a stereological technique. The total number of Purkinje cells in the exposed group was significantly lower than in both the control group (p < 0.004) and the sham-exposed group (p < 0.002). Body and brain weights did not differ significantly between the exposed and unexposed groups.
Rağbetli MC et al. · 2010
Researchers investigated the effect of mobile phone exposure on Purkinje and granule neurons in the developing cerebellum. Pregnant Swiss albino mice were exposed to GSM mobile phone radiation at 890–915 MHz at 0.95 W/Kg specific absorption rate (SAR). The study found a significant decrease in the number of Purkinje cells and a tendency for granule cells to increase.
Maskey D et al. · 2010
Researchers investigated the effect of 835-MHz radiofrequency exposure on rat hippocampus for 3 months using immunohistochemical methods. A decrease in calbindin immunoreactivity was observed in the exposed group, with loss of interneurons and pyramidal cells in the CA1 area and loss of granule cells. An overall increase in GFAP immunoreactivity was observed in the hippocampus of exposed rats, and apoptotic cells were detected in the CA1, CA3 areas and dentate gyrus.
Maskey D et al. · 2010
Researchers measured calbindin (CB) and calretinin (CR) expression in the hippocampus of mice after exposure to 835 MHz electromagnetic fields at various durations and absorption rates. Exposure conditions included 1 hour per day for 5 days at a specific absorption rate of 1.6 W/kg, 1 hour per day for 5 days at 4.0 W/kg, 5 hours per day for 1 day at 1.6 W/kg, 5 hours per day for 1 day at 4.0 W/kg, and daily exposure for 1 month at 1.6 W/kg. Exposure for 1 month produced almost complete loss of pyramidal cells in the CA1 area. Body weights did not change significantly across the exposure groups.
Imge EB, Kiliçoğlu B, Devrim E, Cetin R, Durak I · 2010
Forty female rats were divided into four groups: control, mobile phone, mobile phone plus vitamin C, and vitamin C alone. The mobile phone groups were exposed to a mobile phone signal (900 MHz), and vitamin C was administered orally for four weeks. Mobile phone exposure caused an inhibition in 5'-NT and CAT activities compared to the control group, while GSH-Px activity and MDA levels were reduced but not significantly. The researchers suggested that vitamin C may play a protective role against detrimental effects of mobile phone radiation in brain tissue.
Hao Y, Yang X, Chen C, Yuan-Wang, Wang X, Li M, Yu Z · 2010
Researchers exposed murine N9 microglial cells to 2.45 GHz electromagnetic fields and examined several molecular markers of cell activation. After exposure, a significant increase of STAT3 DNA-binding ability was noted, and EMF rapidly induced phosphorylation of STAT3 and activated JAK1 and JAK2. Transcription levels of the inflammation-associated genes iNOS and TNF-alpha also increased after EMF exposure. When a JAK inhibitor called P6 was applied, it reduced induction of iNOS and TNF-alpha, nuclear factor binding activity, and activation of STAT3 in EMF-stimulated microglia.
Fragopoulou AF et al. · 2010
Researchers tested the effects of mobile phone radiation on spatial learning and memory in mice using the Morris water maze, a hippocampal-dependent spatial memory task. The mice received a 2 h daily dose of pulsed GSM 900 MHz radiation from a commercially available mobile phone for 4 days at SAR values ranging from 0.41 to 0.98 W/kg. Exposed animals showed a deficit in transferring acquired spatial information across training days, with increased escape latency and distance swam compared to sham-exposed animals. During the memory probe trial, sham-exposed animals showed the expected preference for the target quadrant, while exposed animals showed no preference.
